| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peritonitis | D010538 | 38 associated lipids |
| Urticaria Pigmentosa | D014582 | 4 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Hematoma | D006406 | 5 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Wendling MG and DuCharme DW | Cardiovascular effects of prostaglandin D3 and D2 in anesthetized dogs. | 1981 | Prostaglandins | pmid:6945633 |
| Toda N | Different responsiveness of a variety of isolated dog arteries to prostaglandin D2. | 1982 | Prostaglandins | pmid:6950464 |
| Saito H et al. | Bio-synthesis of PGD2 and TXB2 by rabbit blood monocytes. | 1986 | Prostaglandins | pmid:3086936 |
| Li Y et al. | Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. | 1997 | Prostaglandins | pmid:9380795 |
| Higashiyama K et al. | Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. | 1996 | Prostaglandins | pmid:8908616 |
| Okumura T and Saito K | Effect of prostaglandins on glycogenesis and glycogenolysis in primary cultures of rat hepatocytes--a role of prostaglandin D2 in the liver. | 1990 | Prostaglandins | pmid:2353117 |
| Taber DF et al. | A nomenclature system for the isoprostanes. | 1997 | Prostaglandins | pmid:9112285 |
| Westcott JY and Murphy RC | The interaction of ethanol and exogenous arachidonic acid in the formation of leukotrienes and prostaglandin D2 in mastocytoma cells. | 1983 | Prostaglandins | pmid:6316419 |
| McGuire JC et al. | Production of prostaglandin D2 by murine macrophage cell lines. | 1985 | Prostaglandins | pmid:3937182 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Shimizu Y et al. | Cycloheximide reduces PGD2 or delta 12-PGJ2 cytotoxicity on NCG cells. | 1986 | Prostaglandins | pmid:3099333 |
| Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
| Tynan SS et al. | On the multiplicity of platelet prostaglandin receptors. II. The use of N-0164 for distinguishing the loci of action for PGI2, PGD2, PGE2 and hydantoin analogs. | 1984 | Prostaglandins | pmid:6087417 |
| Tasaki Y et al. | Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification. | 1991 | Prostaglandins | pmid:1871375 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Gimeno AL et al. | Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. | 1983 | Prostaglandins | pmid:6361911 |
| Gerritsen ME and Printz MP | Prostaglandin D synthase in microvessels from the rat cerebral cortex. | 1981 | Prostaglandins | pmid:6119739 |
| Maclouf J et al. | Development of a radioimmunoassay for prostaglandin D2 using an antiserum against 11-methoxime prostaglandin D2. | 1986 | Prostaglandins | pmid:3456623 |
| Seiler S et al. | SQ-27986 inhibition of platelet aggregation is mediated through activation of platelet prostaglandin D2 receptors. | 1990 | Prostaglandins | pmid:2171039 |
| Alvarez R et al. | Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin. | 1991 | Prostaglandins | pmid:1775633 |
| Lysz TW et al. | Kupffer cell-hepatocyte interactions and the changes in 1-14C-arachidonate incorporation in response to endotoxin in vitro. | 1990 | Prostaglandins | pmid:2112770 |
| Bulbena O et al. | Mast cells in the rat gastric mucosa are not primarily responsible for PGD2 generation. | 1991 | Prostaglandins | pmid:1871377 |
| Heavey DJ et al. | Effects of intravenous infusions of prostaglandin D2 in man. | 1984 | Prostaglandins | pmid:6596653 |
| Nakahata N et al. | PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. | 1990 | Prostaglandins | pmid:2177901 |
| Bregman MD and Meyskens FL | In vitro modulation of human and murine melanoma growth by prostanoid analogues. | 1983 | Prostaglandins | pmid:6581509 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
| Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
| Smith GS et al. | Adaptive cytoprotection against alcohol injury in the rat stomach is not due to increased prostanoid synthesis. | 1991 | Prostaglandins | pmid:1906621 |
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
| Cebola I and Peinado MA | Epigenetic deregulation of the COX pathway in cancer. | 2012 | Prog. Lipid Res. | pmid:22580191 |
| Hemker DP and Aiken JW | Effects of prostaglandins on autonomic function in vivo, with special emphasis on PGD2 and PGD3. | 1981 | Prog. Lipid Res. | pmid:6952267 |
| Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
| Thierauch KH et al. | ZK 110 841--a selective and potent prostaglandin D2 analogue. | 1989 | Prog. Clin. Biol. Res. | pmid:2798462 |
| Philips JB and Lyrene RK | Persistent pulmonary hypertension and prostaglandin D2. | 1983 | Prog. Clin. Biol. Res. | pmid:6577475 |
| Honn KV et al. | Possible strategies for antimetastastic therapy. | 1986 | Prog. Clin. Biol. Res. | pmid:3520578 |
| Bhattacharya SK et al. | Prostaglandin D2 mediated specific increase in rat brain serotonin. | 1985 | Proc. West. Pharmacol. Soc. | pmid:3865228 |
| Gause GE et al. | Hemodynamic effects of postpulmonary administration of prostaglandin D2 in fetal animals. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3858885 |
| Koharudin LM et al. | Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20231490 |
| Qu WM et al. | Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17093043 |
| Vong L et al. | A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20547854 |
| Murata T et al. | Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23479612 |
| Ueno R et al. | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6964402 |
| Satoh S et al. | Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8650205 |
| Khan SH and Sorof S | Preferential binding of growth inhibitory prostaglandins by the target protein of a carcinogen. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2251282 |
| Cheng K et al. | Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16617107 |
| Hwang SW et al. | Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823958 |
| Straus DS et al. | 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781090 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Murata T et al. | Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106279 |
| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
| Kondo M et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032289 |
| Yamashita A et al. | Autoradiographic localization of a binding protein(s) specific for prostaglandin D2 in rat brain. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6310617 |
| Eguchi N et al. | Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9892701 |
| Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
| Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
| Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
| Scammell T et al. | Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9636223 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
| Rajakariar R et al. | Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077391 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3456602 |
| Petrova TV et al. | Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200320 |
| Haworth O and Buckley CD | Resolving the problem of persistence in the switch from acute to chronic inflammation. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18093938 |
| Eggler AL et al. | Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16006525 |
| Kuno S et al. | Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3458226 |
| Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
| Oliva JL et al. | The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12684535 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Hirata M et al. | Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972033 |
| Watanabe Y et al. | Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6308629 |
| Inoué S et al. | Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6592612 |
| Onoe H et al. | Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3163802 |
| Mizoguchi A et al. | Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11562489 |
| Kikawa Y et al. | 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6584883 |
| Nakagawa S et al. | Evaluation of prostaglandin D2 (PGD2) as an anticoagulative agent for haemodialysis in comparison with prostaglandin E1 (PGE1). | 1981 | Proc Eur Dial Transplant Assoc | pmid:7036145 |
| Bochenek G et al. | [Prostaglandin D2: biosynthesis, biological properties and participation in bronchial asthma]. | 2001 | Pol. Arch. Med. Wewn. | pmid:11928572 |
| Gross-Sondej I et al. | [Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease]. | 2012 | Pneumonol Alergol Pol | pmid:22370980 |
| Magnussen H et al. | [Experimental effects of air pollutants on healthy probands and asthmatic patients]. | 1994 | Pneumologie | pmid:8183874 |
| Haxhiu MA et al. | [Bronchial response to prostaglandins (F2 alpha and D2) and leukotrienes in patients with bronchial asthma]. | 1986 Jan-Mar | Plucne Bolesti | pmid:3466189 |
| Yang G et al. | Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism. | 2012 | PLoS ONE | pmid:22899986 |
| Lefils-Lacourtablaise J et al. | The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. | 2013 | PLoS ONE | pmid:23734181 |
| Benedetti F and Dogue S | Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. | 2015 | PLoS ONE | pmid:26536471 |
| Wappler EA et al. | Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures. | 2013 | PLoS ONE | pmid:23658809 |
| Nicholson JD et al. | PGJ(2) provides prolonged CNS stroke protection by reducing white matter edema. | 2012 | PLoS ONE | pmid:23284631 |
| Isensee J et al. | Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. | 2014 | PLoS ONE | pmid:25551770 |
| Gonzalez-Rodriguez PJ et al. | Dexamethasone protects neonatal hypoxic-ischemic brain injury via L-PGDS-dependent PGD2-DP1-pERK signaling pathway. | 2014 | PLoS ONE | pmid:25474649 |
| Paulitschke V et al. | Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. | 2012 | PLoS ONE | pmid:23049949 |
| Yamamoto Y et al. | Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. | 2011 | PLoS ONE | pmid:21445266 |
| Yazid S et al. | Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. | 2013 | PLoS ONE | pmid:23527056 |
| Liu L et al. | Inhibition of oxidative stress-elicited AKT activation facilitates PPARγ agonist-mediated inhibition of stem cell character and tumor growth of liver cancer cells. | 2013 | PLoS ONE | pmid:24023668 |
| Sharvit E et al. | Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. | 2013 | PLoS ONE | pmid:24098526 |
| Seno T et al. | 15-Deoxy-Δ¹²,¹ⴠprostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. | 2011 | PLoS ONE | pmid:22003398 |
| de Jong E et al. | Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. | 2011 | PLoS ONE | pmid:21957481 |
| Weng Z et al. | Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. | 2012 | PLoS ONE | pmid:22470478 |
| Kida T et al. | Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. | 2016 | PLoS ONE | pmid:27992456 |
| de Melo NF et al. | 15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. | 2016 | PLoS ONE | pmid:27575486 |
| Philipose S et al. | Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation. | 2012 | PLoS ONE | pmid:22870195 |