PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Peritonitis D010538 38 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Hematoma D006406 5 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
pmid:28262205
Dieter P et al. Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. 1987 Eur. J. Biochem. pmid:2826152
Richelsen B Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. 1987 Biochem. Pharmacol. pmid:2825710
Viganò T et al. Adenosine and eicosanoid release from immunologically challenged human lung fragments. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823581
Omini C et al. Prostaglandin D2 and the cholinergic system in guinea pig airways. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823557
Zijlstra FJ et al. Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187. 1987 Eur. J. Clin. Invest. pmid:2822430
El-Shazly AE et al. Tyrosine kinase inhibition is an important factor for gene expression of CRTH2 in human eosinophils and lymphocytes: A novel mechanism for explaining eosinophils recruitment by the neuro-immune axis in allergic rhinitis. 2017 Int. Immunopharmacol. pmid:28222358
pmid:28216619
Bushfield M et al. Effects of protein kinase C activation on human platelet cyclic AMP metabolism. 1987 FEBS Lett. pmid:2820806
pmid:28195470
Robinson C et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. 1989 Biochem. Pharmacol. pmid:2818626
Kuiper J et al. Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells. 1989 Biochem. J. pmid:2818563
Tejedor M et al. Potentiation of radiation toxicity in C-6 glioma cells by prostaglandin D2. 1989 Jul-Aug Anticancer Res. pmid:2817802
pmid:28174214
Tang Q et al. Effect of 15-Deoxy-Δ12,14-prostaglandin J2Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model. 2017 Chin. Med. J. pmid:28139520
Kutyrev IA et al. Prostaglandins E2 and D2-regulators of host immunity in the model parasite Diphyllobothrium dendriticum: An immunocytochemical and biochemical study. 2017 Mol. Biochem. Parasitol. pmid:28137629
pmid:28137499
pmid:28115365
Salimi M et al. Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines. 2017 J. Allergy Clin. Immunol. pmid:28115217
pmid:28112177
pmid:28102732
Giménez-Bastida JA et al. Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. 2017 FASEB J. pmid:28096231
Deckers IA et al. Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue. 1989 Eur. J. Pharmacol. pmid:2806380
pmid:28057839
Wallace DI et al. A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2. 2016 Comput Math Methods Med pmid:28044089
pmid:28025147
Kida T et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. 2016 PLoS ONE pmid:27992456
pmid:27984728
Thierauch KH et al. ZK 110 841--a selective and potent prostaglandin D2 analogue. 1989 Prog. Clin. Biol. Res. pmid:2798462
Ehara H [An experimental study on antitumor effect of prostaglandin D2]. 1989 Nihon Geka Gakkai Zasshi pmid:2796985
Emery DL et al. Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. 1989 J. Appl. Physiol. pmid:2793725
pmid:27898338
Carregaro V et al. Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 (15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25-FOXP3+ Cells. 2016 Mediators Inflamm. pmid:27872515
pmid:27872193
pmid:27815021
pmid:27771378
Coe JY et al. A fetal-instrumented model to study age-specific responses to leukotriene D4 and prostaglandin D2 in unsedated newborn lambs. 1989 Can. J. Physiol. Pharmacol. pmid:2776077
Dieter P et al. 4-Bromophenacyl bromide inhibits prostaglandin D2 synthesis from arachidonic acid rather than phospholipase A2 activity in liver macrophages. 1989 Biol. Chem. Hoppe-Seyler pmid:2775481
Hayaishi O Prostaglandin D2 and sleep. 1989 Ann. N. Y. Acad. Sci. pmid:2774407
pmid:27741434
pmid:27732913
Napier FE and Temple DM The influence of xanthines on the contractile responses of PGF2 alpha and PGD2 in human parenchymal strips. 1989 Prostaglandins pmid:2772222
pmid:27693222
Guan NN et al. Prostaglandin D2 effects and DP1 /DP2 receptor distribution in guinea pig urinary bladder out-flow region. 2017 J. Cell. Mol. Med. pmid:27664012
pmid:27663184
Suganami A et al. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. 2016 FEBS J. pmid:27636113
pmid:27628164
Kong D et al. PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. 2016 J. Exp. Med. pmid:27621415
pmid:27602490
de Melo NF et al. 15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. 2016 PLoS ONE pmid:27575486
pmid:27572109
Li WY et al. Effect of 15-Deoxy-â–³(12,14)-prostaglandin J2 on Expression of Macrophage Migration Inhibitory Factor in Mouse Monocyte/macrophage Cell Line J774A.1. 2016 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:27544994
Shin JS et al. Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry. 2016 J Chromatogr A pmid:27524299
Muhammad SN et al. 15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. 2016 Asian Pac. J. Cancer Prev. pmid:27509924
Murata T and Maehara T Discovery of anti-inflammatory role of prostaglandin D2. 2016 J. Vet. Med. Sci. pmid:27498997
Ashida Y et al. A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. 1989 Prostaglandins pmid:2748922
pmid:27485270
pmid:27481693
pmid:27453569
Tsujimoto S et al. Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. 2016 Int. J. Mol. Med. pmid:27431935
Feng X et al. Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease. 2016 J. Allergy Clin. Immunol. pmid:27423494
Abbasi S et al. Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion. 2016 Int J Nanomedicine pmid:27354798
Saitoh O et al. Effect of amogastrin on the release of various prostaglandins into gastric lumen in man. 1989 Mar-Apr Jpn. J. Med. pmid:2733241
pmid:27329155
Raisz LG and Woodiel FN Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. 1989 Prostaglandins pmid:2727307
pmid:27271931
pmid:27255640
Wolfe LS et al. Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. 1989 J. Neurochem. pmid:2723663
pmid:27210044
pmid:27185495
pmid:27178890
pmid:27140063
pmid:27133055
Phillips JE et al. Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma. 2016 J Aerosol Med Pulm Drug Deliv pmid:27111445
pmid:27095392
pmid:27094922
Kanai K et al. Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts. 2016 Allergol Int pmid:27091669
Ma J et al. Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload. 2016 Sci Rep pmid:27089935
Kuiper J et al. Induction of ornithine decarboxylase in rat liver by phorbol ester is mediated by prostanoids from Kupffer cells. 1989 J. Biol. Chem. pmid:2708347
Zhou J et al. Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats. 2016 J. Cell. Mol. Med. pmid:27061967
pmid:27060220
pmid:27055381
pmid:27050800
Wang M et al. The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. 2016 Biol. Pharm. Bull. pmid:27040628
pmid:27032756
Preclik G et al. Alimentary tract and pancreas. Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment. 1989 Gut pmid:2703138
pmid:26999671
pmid:26995677
Nagira Y et al. Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs. 2016 J. Pharmacol. Exp. Ther. pmid:26945085
Hölscher C et al. Defects in Peroxisomal 6-Phosphogluconate Dehydrogenase Isoform PGD2 Prevent Gametophytic Interaction in Arabidopsis thaliana. 2016 Plant Physiol. pmid:26941195
Watanabe K [Structure and function of prostaglandin F synthetase]. 1989 Seikagaku pmid:2693551
Bambouskova M et al. New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling. 2016 Mol. Cell. Biol. pmid:26929198
Sykes DA et al. Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy. 2016 Mol. Pharmacol. pmid:26916831
pmid:26897856
Shibata T et al. Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. 2016 Sci Rep pmid:26879669
Yoon YS et al. Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF. 2016 Sci Rep pmid:26875548
Walther U et al. Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway. 2016 Oncotarget pmid:26863638
Huang L et al. 15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model. 2015 Biomed Res Int pmid:26844229
Laidlaw TM and Boyce JA Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. 2016 N. Engl. J. Med. pmid:26840139
Vishwakarma P et al. 15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis. 2016 J. Mol. Med. pmid:26830627