| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| HIV Seropositivity | D006679 | 15 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hyperlipoproteinemia Type IV | D006953 | 6 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mezawa A | [Nasal response to chemical mediators in nasal allergy]. | 1988 | Nippon Jibiinkoka Gakkai Kaiho | pmid:3199260 |
| Casteleijn E et al. | Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication. | 1988 | J. Biol. Chem. | pmid:3284878 |
| Ikai K and Imamura S | Prostaglandin D2 in the skin. | 1988 | Int. J. Dermatol. | pmid:3286543 |
| Hardy CC et al. | Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. | 1988 | J. Appl. Physiol. | pmid:3288608 |
| Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
| Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
| Hoult JR et al. | Organ selective conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and its subsequent metabolism in rat, rabbit and guinea pig. | 1988 | Biochem. Pharmacol. | pmid:3178873 |
| Nakamura O et al. | [Antineoplastic effect of prostaglandins on human glioma in athymic nude mice]. | 1988 | No To Shinkei | pmid:3179087 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Undem BJ and Adams GK | An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839671 |
| Fukushima M | [Prostaglandin J2--anti-tumor activity and mechanism of action]. | 1988 | Nippon Rinsho | pmid:3043050 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Yokotani K et al. | Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3422095 |
| Robinson C et al. | The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | 1988 | Biochim. Biophys. Acta | pmid:3196723 |
| Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| Kawabe H et al. | Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2436614 |
| Watanabe Y et al. | Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960207 |
| Hayaishi O et al. | Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960208 |
| Narumiya S and Fukushima M | Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960214 |
| Ruzicka T and Auböck J | Arachidonic acid metabolism in guinea pig Langerhans cells: studies on cyclooxygenase and lipoxygenase pathways. | 1987 | J. Immunol. | pmid:3098849 |
| Ono K et al. | Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960215 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Saito R et al. | The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. | 1987 | Pharmacol. Biochem. Behav. | pmid:2883669 |
| Brown MS et al. | Arachidonic acid metabolites during nasal challenge. | 1987 | Arch. Otolaryngol. Head Neck Surg. | pmid:3099812 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. | 1987 | Pharm. Res. | pmid:2977646 |
| Anton RF and Randall CL | Central nervous system prostaglandins and ethanol. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3105343 |
| Santoro MG et al. | PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. | 1987 | J. Gen. Virol. | pmid:3033130 |
| Church MK and Hiroi J | Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. | 1987 | Br. J. Pharmacol. | pmid:2435353 |
| Williams KA et al. | Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. | 1987 | Biochem. J. | pmid:2444206 |
| Lawrence ID et al. | Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity. | 1987 | J. Immunol. | pmid:2444649 |
| Benyon RC et al. | Prostaglandin D2 release from human skin mast cells in response to ionophore A23187. | 1987 | Br. J. Pharmacol. | pmid:2447989 |
| Underwood DC et al. | Blockade of thromboxane responses in the airway of the cat by SQ 29,548. | 1987 | J. Appl. Physiol. | pmid:2440845 |
| Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
| Leung KB et al. | Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. | 1987 | Agents Actions | pmid:2440274 |
| Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
| Tilden SJ et al. | Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. | 1987 | J. Appl. Physiol. | pmid:2954941 |
| Tran-Thi TA et al. | Studies on synthesis and degradation of eicosanoids by rat hepatocytes in primary culture. | 1987 | J. Hepatol. | pmid:2828463 |
| Amano N | [Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats]. | 1987 | Masui | pmid:3480360 |
| Brunelli G et al. | PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig. | 1987 | J Auton Pharmacol | pmid:3480891 |
| Weinreich D and Wonderlin WF | Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. | 1987 | J. Physiol. (Lond.) | pmid:3481834 |
| Nakamura M et al. | In vivo effects of prostaglandins on human retinoblastoma cells in nude mice. | 1987 | Jpn. J. Ophthalmol. | pmid:3482290 |
| Shimojima T et al. | [Effects of prostaglandins on superoxide production by human polymorphonuclear leukocytes]. | 1987 | Nihon Shishubyo Gakkai Kaishi | pmid:2851629 |