| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thyroid Diseases | D013959 | 8 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Sleep Wake Disorders | D012893 | 7 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pritts EA et al. | Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element. | 2003 | Fertil. Steril. | pmid:12909507 |
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| Zhang M et al. | [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:12921638 |
| Mitsumori S et al. | Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane derivatives. | 2003 | J. Med. Chem. | pmid:12773048 |
| Kim EJ et al. | Peroxisome proliferator-activated receptor-gamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis: association with extracellular signal-regulated kinase signal pathway. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12966153 |
| Collin M and Thiemermann C | The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. | 2003 | Eur. J. Pharmacol. | pmid:12969773 |
| Caivano M et al. | 15-Deoxy-Delta12,14-prostaglandin J2 regulates endogenous Cot MAPK kinase kinase 1 activity induced by lipopolysaccharide. | 2003 | J. Biol. Chem. | pmid:14557273 |
| Murakami Y et al. | Inhibition of monosodium urate monohydrate crystal-induced acute inflammation by retrovirally transfected prostaglandin D synthase. | 2003 | Arthritis Rheum. | pmid:14558100 |
| Niyonsaba F et al. | Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. | 2003 | Curr Drug Targets Inflamm Allergy | pmid:14561157 |
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| Paumi CM et al. | Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. | 2003 | Biochemistry | pmid:12731885 |
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| Chen SY et al. | 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. | 2002 | Anticancer Drugs | pmid:12187333 |
| Yamamoto S et al. | Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha. | 2002 | Biochem. Pharmacol. | pmid:12147288 |
| Sakurai S et al. | Retinal capillary pericyte proliferation and c-Fos mRNA induction by prostaglandin D2 through the cAMP response element. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147615 |
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| Miyazaki Y et al. | Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12150985 |
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| Nishida K et al. | Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. | 2002 | Br. J. Cancer | pmid:11953889 |
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| Tzanakakis GN et al. | The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. | 2002 | Int J Gastrointest Cancer | pmid:12630766 |
| Diaz BL et al. | Participation of cytosolic phospholipase A2 in eicosanoid generation by mouse bone marrow-derived mast cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664562 |
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| Whigham LD et al. | Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893615 |
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| Yang X et al. | Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12444028 |
| Nikitakis NG et al. | 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. | 2002 | Br. J. Cancer | pmid:12454768 |
| Fahmi H et al. | 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. | 2002 | Osteoarthr. Cartil. | pmid:12435328 |
| Vitzthum H et al. | Gene expression of prostanoid forming enzymes along the rat nephron. | 2002 | Kidney Int. | pmid:12371957 |
| Higashi N et al. | A comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma. | 2002 | Clin. Exp. Allergy | pmid:12372129 |
| Zhang J et al. | 15-Deoxy-prostaglandin J(2) inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPAR gamma. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379230 |
| Nithipatikom K et al. | Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion. | 2002 | Clin. Exp. Metastasis | pmid:12498388 |