Yang G et al. |
Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism. |
2012 |
PLoS ONE |
pmid:22899986
|
Wang P et al. |
The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. |
2012 |
J. Biol. Chem. |
pmid:22829602
|
Nicholson JD et al. |
PGJ(2) provides prolonged CNS stroke protection by reducing white matter edema. |
2012 |
PLoS ONE |
pmid:23284631
|
Xiao L et al. |
Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages. |
2012 |
PLoS ONE |
pmid:23226252
|
Wang Y et al. |
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. |
2012 |
Bioorg. Med. Chem. Lett. |
pmid:22119474
|
Alba G et al. |
Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. |
2012 |
PLoS ONE |
pmid:23115616
|
Hossain MS et al. |
Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. |
2012 |
Exp. Cell Res. |
pmid:22100987
|
Pettipher R et al. |
Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22106101
|
Paulitschke V et al. |
Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. |
2012 |
PLoS ONE |
pmid:23049949
|
Bain G et al. |
Pharmacodynamics, pharmacokinetics, and safety of AM211: a novel and potent antagonist of the prostaglandin D2 receptor type 2. |
2012 |
J Clin Pharmacol |
pmid:22110163
|
Syeda PK et al. |
A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes. |
2012 |
Hybridoma (Larchmt) |
pmid:23098304
|
Gates D et al. |
Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism. |
2012 |
Biochim. Biophys. Acta |
pmid:22138303
|
Weng Y et al. |
Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. |
2012 |
Mol Pain |
pmid:23013719
|
Ruiz M et al. |
A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. |
2012 |
PLoS ONE |
pmid:23056435
|
Ravindra KC et al. |
Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438). |
2012 |
Chem. Res. Toxicol. |
pmid:22141352
|
Maurer M and Church MK |
Inflammatory skin responses induced by icatibant injection are mast cell mediated and attenuated by H(1)-antihistamines. |
2012 |
Exp. Dermatol. |
pmid:22142018
|
Fujimori K et al. |
Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. |
2012 |
J. Neurochem. |
pmid:22043816
|
Chae HS and Chin YW |
Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. |
2012 |
Immunopharmacol Immunotoxicol |
pmid:21854102
|
Miyawaki T et al. |
Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. |
2012 |
Immunopharmacol Immunotoxicol |
pmid:21854184
|
Maicas N et al. |
Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. |
2012 |
Arthritis Rheum. |
pmid:21898357
|
Kaneko K et al. |
Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide. |
2012 |
Neuropeptides |
pmid:23141054
|
Sedej M et al. |
D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells. |
2012 |
J. Allergy Clin. Immunol. |
pmid:21930295
|
Higuchi S et al. |
Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. |
2012 |
J Appl Toxicol |
pmid:21735453
|
Pasvanis S et al. |
High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:22293191
|
Li X et al. |
Natural vanadium-containing Jeju groundwater inhibits immunoglobulin E-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells. |
2012 |
Biol. Pharm. Bull. |
pmid:22293352
|
Springstead JR et al. |
Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. |
2012 |
J. Lipid Res. |
pmid:22550136
|
Xue L et al. |
Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2. |
2012 |
J. Immunol. |
pmid:22174450
|
He S et al. |
Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella). |
2012 |
Comp. Biochem. Physiol. C Toxicol. Pharmacol. |
pmid:22079418
|
Hossain MS et al. |
Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes. |
2012 |
Gene |
pmid:22561694
|
Oda A et al. |
Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity. |
2012 |
J. Neurochem. |
pmid:22564055
|
Clemente-Napimoga JT et al. |
15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. |
2012 |
Life Sci. |
pmid:22564409
|
Inceoglu AB et al. |
Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. |
2012 |
J. Cardiovasc. Pharmacol. |
pmid:22526297
|
Higashi N et al. |
Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites. |
2012 |
Allergol Int |
pmid:22627848
|
Kristensen DM et al. |
Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. |
2012 |
Int. J. Androl. |
pmid:22612476
|
Hogrefe C et al. |
Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches. |
2012 |
Int. J. Mol. Med. |
pmid:22922824
|
Lee E et al. |
15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes. |
2012 |
Free Radic. Biol. Med. |
pmid:22245093
|
Lee S et al. |
Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects. |
2012 |
J. Biol. Chem. |
pmid:22275363
|
Ledwidge MT et al. |
In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin? |
2012 |
Atherosclerosis |
pmid:22326030
|
Baek K et al. |
Myeloid Elf-1-like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator-activated receptor γ expression in bone marrow. |
2012 |
J. Cell. Physiol. |
pmid:22307523
|
MartÃnez AE et al. |
15-Deoxy-Δ(12,14)-prostaglandin J2 exerts pro- and anti-inflammatory effects in mesangial cells in a concentration-dependent manner. |
2012 |
Inflamm Allergy Drug Targets |
pmid:22309084
|
Fujita M et al. |
Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. |
2012 |
Int J Med Sci |
pmid:22991494
|
Ito H et al. |
PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. |
2012 |
J. Am. Soc. Nephrol. |
pmid:22997255
|
Wu CC et al. |
Involvement of the prostaglandin D2 signal pathway in retinoid-inducible gene 1 (RIG1)-mediated suppression of cell invasion in testis cancer cells. |
2012 |
Biochim. Biophys. Acta |
pmid:22960220
|
Song HH et al. |
Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. |
2012 |
Am. J. Chin. Med. |
pmid:22928836
|
Tachikawa M et al. |
A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22931759
|
Fredman G et al. |
Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. |
2012 |
Sci Rep |
pmid:22957142
|
Matzkin ME et al. |
Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. |
2012 |
Gen. Comp. Endocrinol. |
pmid:22974512
|
Myeku N et al. |
cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. |
2012 |
Neurosci. Lett. |
pmid:22982149
|
Mechiche H et al. |
Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. |
2012 |
PLoS ONE |
pmid:22984630
|
Shim J et al. |
Change in prostaglandin expression levels and synthesizing activities in dry eye disease. |
2012 |
Ophthalmology |
pmid:22858125
|
Chae HS et al. |
Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells. |
2012 |
Immunopharmacol Immunotoxicol |
pmid:22229445
|
Nakahigashi K et al. |
PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. |
2012 |
J. Allergy Clin. Immunol. |
pmid:22206772
|
Lu Y et al. |
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. |
2012 |
Food Chem. Toxicol. |
pmid:22154852
|
Hewson CA et al. |
Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22160268
|
Mantel A et al. |
Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. |
2012 |
J. Invest. Dermatol. |
pmid:22170488
|
Farnesi-de-Assunção TS et al. |
PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. |
2012 |
Cell. Immunol. |
pmid:22192475
|
Kuriyan AE et al. |
Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. |
2012 |
Exp. Eye Res. |
pmid:22178289
|
Baudouin-Legros M et al. |
Long-term CFTR inhibition modulates 15d-prostaglandin J2 in human pulmonary cells. |
2012 |
Int. J. Biochem. Cell Biol. |
pmid:22481026
|
Weng Z et al. |
Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. |
2012 |
PLoS ONE |
pmid:22470478
|
Takahashi G et al. |
The potential role of prostaglandin D2 in nasal congestion observed in a guinea pig model of allergic rhinitis. |
2012 |
Int. Arch. Allergy Immunol. |
pmid:22472859
|
Abdo H et al. |
The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹â´-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. |
2012 |
J. Physiol. (Lond.) |
pmid:22473776
|
Ji Y et al. |
Activation of rat intestinal mucosal mast cells by fat absorption. |
2012 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:22461027
|
Kim SE et al. |
15-deoxy-Δ¹²,¹ⴠ-prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-γ and heme oxygenase-1 in rat hippocampal slices. |
2012 |
J. Neurosci. Res. |
pmid:22487967
|
Garza LA et al. |
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. |
2012 |
Sci Transl Med |
pmid:22440736
|
Cloutier A et al. |
The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. |
2012 |
J. Infect. Dis. |
pmid:22219346
|
Sykes L et al. |
Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. |
2012 |
Mediators Inflamm. |
pmid:22690041
|
Raman P et al. |
15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. |
2012 |
J. Pharmacol. Exp. Ther. |
pmid:22700433
|
Cao DS et al. |
Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. |
2012 |
PLoS ONE |
pmid:22701540
|
Yue L et al. |
Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. |
2012 |
Bone |
pmid:22705147
|
Napimoga MH et al. |
Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. |
2012 |
J. Immunol. |
pmid:22706081
|
Qiu H et al. |
Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. |
2012 |
Cardiovasc. Res. |
pmid:22707158
|
Luyer MD |
Enteric neuroprotection. |
2012 |
J. Physiol. (Lond.) |
pmid:22707588
|
Nagata N and Urade Y |
[Sleep-wake regulation by prostaglandin D2 and adenosine]. |
2012 |
Brain Nerve |
pmid:22647469
|
Fujimori K et al. |
Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways. |
2012 |
Gene |
pmid:22664386
|
Cebola I and Peinado MA |
Epigenetic deregulation of the COX pathway in cancer. |
2012 |
Prog. Lipid Res. |
pmid:22580191
|
Liu X et al. |
15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. |
2012 |
Eur. J. Cell Biol. |
pmid:22560326
|
Gross-Sondej I et al. |
[Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease]. |
2012 |
Pneumonol Alergol Pol |
pmid:22370980
|
Han Z et al. |
15-deoxy-Δ12,14 -prostaglandin J2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. |
2012 |
Hepatology |
pmid:22371273
|
Song WL et al. |
Niacin and biosynthesis of PGDâ‚‚by platelet COX-1 in mice and humans. |
2012 |
J. Clin. Invest. |
pmid:22406532
|
Nagata N and Urade Y |
[Endogenous sleep-promoting substance]. |
2012 |
Nippon Rinsho |
pmid:22844810
|
Philipose S et al. |
Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation. |
2012 |
PLoS ONE |
pmid:22870195
|
Keum JH et al. |
The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells. |
2013 |
Chin J Integr Med |
pmid:23494327
|
Zhang S et al. |
Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents. |
2013 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:23471341
|
Welter H et al. |
Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. |
2013 |
Andrology |
pmid:23413143
|
Moreira V et al. |
A catalytically-inactive snake venom Lys49 phospholipase Aâ‚‚ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. |
2013 |
Eur. J. Pharmacol. |
pmid:23416211
|
Heilmann S et al. |
No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. |
2013 |
Br. J. Dermatol. |
pmid:23448296
|
Kanda H et al. |
COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. |
2013 |
Glia |
pmid:23505121
|
Haskew-Layton RE et al. |
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. |
2013 |
J. Neurochem. |
pmid:23199167
|
Nakamura M et al. |
Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. |
2013 |
Biomed. Pharmacother. |
pmid:23206752
|
Lewis A et al. |
Heterogeneity in the responses of human lung mast cells to stem cell factor. |
2013 |
Clin. Exp. Allergy |
pmid:23278880
|
Hellmann J et al. |
Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. |
2013 |
J. Immunol. |
pmid:23785121
|
Moghaddami M et al. |
Prostaglandin D(2) in inflammatory arthritis and its relation with synovial fluid dendritic cells. |
2013 |
Mediators Inflamm. |
pmid:23737645
|
Labrecque P et al. |
Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. |
2013 |
PLoS ONE |
pmid:23762421
|
Lu Y et al. |
Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappaB and mitogen activated protein kinase pathways in bone marrow derived-mast cells. |
2013 |
Biol. Pharm. Bull. |
pmid:23719635
|
Yoo JM et al. |
Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. |
2013 |
Lipids |
pmid:23377981
|
Fajt ML et al. |
Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. |
2013 |
J. Allergy Clin. Immunol. |
pmid:23506843
|
Ramer R et al. |
Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. |
2013 |
J. Lipid Res. |
pmid:23943857
|
Bolton C et al. |
N-Methyl-D-aspartate (NMDA) receptor involvement in central nervous system prostaglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE). |
2013 |
Fundam Clin Pharmacol |
pmid:22742874
|
Kattamuri PV et al. |
Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. |
2013 |
Life Sci. |
pmid:22820546
|
Parson HK et al. |
Role of prostaglandin D2 and the autonomic nervous system in niacin-induced flushing. |
2013 |
J Diabetes |
pmid:22727040
|