Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Masuko-Hongo K | [Role of prostaglandins in rheumatoid arthritis]. | 2005 | Nippon Rinsho | pmid:15799333 |
Yuan J et al. | Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. | 2005 | Urology | pmid:15780399 |
Kim S et al. | Synthesis of 15R-PGD2: a potential DP2 receptor agonist. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15780624 |
Marshall JC | Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome? | 2005 | Intensive Care Med | pmid:15782317 |
Gazi L et al. | Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789622 |
Fowler CJ and Tiger G | Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | 2005 | Biochem. Pharmacol. | pmid:15794945 |
Dore-Duffy P et al. | The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series. | 2005 | Microvasc. Res. | pmid:15797264 |
Liu J et al. | Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15838654 |
Ji JD et al. | Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. | 2005 | Rheumatology (Oxford) | pmid:15840591 |
Mitchell MD et al. | Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15840748 |
Sanchez-Rodriguez J et al. | The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. | 2005 | Biochem. J. | pmid:15819613 |
Kim YS et al. | Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. | 2005 | Free Radic. Biol. Med. | pmid:15589375 |
Almishri W et al. | Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15590767 |
Hwang J et al. | Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590897 |
López-Parra M et al. | The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. | 2005 | J. Hepatol. | pmid:15629510 |
Scher JU and Pillinger MH | 15d-PGJ2: the anti-inflammatory prostaglandin? | 2005 | Clin. Immunol. | pmid:15639643 |
Hata AN et al. | Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. | 2005 | Mol. Pharmacol. | pmid:15563582 |
Chou YH et al. | The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. | 2005 | Int. J. Biochem. Cell Biol. | pmid:15618017 |
Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
Liu JJ et al. | Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. | 2005 | Ann. Oncol. | pmid:15642706 |
Wu CC et al. | 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. | 2005 | Eur. J. Pharmacol. | pmid:16313903 |
Coyle AT et al. | 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. | 2005 | FEBS J. | pmid:16156795 |
Chen WC et al. | Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity. | 2005 | Chin. Med. J. | pmid:16157051 |
Uehara Y | [Prostaglandin D2]. | 2005 | Nippon Rinsho | pmid:16149440 |
Negoro H et al. | Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. | 2005 | Life Sci. | pmid:16154157 |
O'Flaherty JT et al. | 5-Oxo-ETE analogs and the proliferation of cancer cells. | 2005 | Biochim. Biophys. Acta | pmid:16154383 |
Schmidt R et al. | LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16172029 |
Wilhelm D et al. | Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. | 2005 | Dev. Biol. | pmid:16185683 |
Armer RE et al. | Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. | 2005 | J. Med. Chem. | pmid:16190744 |
Koh SH et al. | 15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant? | 2005 | Toxicology | pmid:16191461 |
Soares AF et al. | Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16198309 |
Xue L et al. | Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. | 2005 | J. Immunol. | pmid:16272307 |
Yuhas Y et al. | Involvement of prostaglandins in an animal model of Shigella-related seizures. | 2005 | J. Neuroimmunol. | pmid:16139898 |
Gayarre J et al. | Differential selectivity of protein modification by the cyclopentenone prostaglandins PGA1 and 15-deoxy-Delta12,14-PGJ2: role of glutathione. | 2005 | FEBS Lett. | pmid:16223487 |
Hatoum OA et al. | Novel mechanism of vasodilation in inflammatory bowel disease. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141408 |
Noguchi J et al. | Strain difference of murine bone marrow-derived mast cell functions. | 2005 | J. Leukoc. Biol. | pmid:16126842 |
Marone G et al. | Role of human mast cells and basophils in bronchial asthma. | 2005 | Adv. Immunol. | pmid:16227089 |
Jin YR et al. | An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. | 2005 | Basic Clin. Pharmacol. Toxicol. | pmid:16128910 |
Fujishima H et al. | Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis. | 2005 | Cornea | pmid:16227827 |
Kobayashi Y et al. | Physiological levels of 15-deoxy-Delta12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma ligation. | 2005 | J. Immunol. | pmid:16237065 |
Na HK et al. | ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells. | 2005 | FEBS Lett. | pmid:16253239 |
Sugimoto H et al. | CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. | 2005 | Eur. J. Pharmacol. | pmid:16256979 |
Iwata C et al. | Augmentation of lipogenesis by 15-deoxy-Delta12,14-prostaglandin J2 in hamster sebaceous glands: identification of cytochrome P-450-mediated 15-deoxy-Delta12,14-prostaglandin J2 production. | 2005 | J. Invest. Dermatol. | pmid:16297182 |
Thomas RK et al. | Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. | 2005 | Clin. Cancer Res. | pmid:16299251 |
Sugimoto M et al. | Increased scratching counts depend on a decrease in ability of cutaneous prostaglandin D2 biosynthesis in NC/Nga mice with atopic dermatitis. | 2005 | Exp. Dermatol. | pmid:16274457 |
Shiraki T et al. | [Activation mechanism of PPARgamma by its endogenous ligands]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16277244 |
Bianchi A et al. | Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. | 2005 | Arthritis Res. Ther. | pmid:16277686 |
Shibata T and Uchida K | [Current opinions on prostaglandin J2]. | 2005 | Seikagaku | pmid:16241007 |
Shiraishi Y et al. | Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15528449 |
Muñoz U et al. | The cyclopentenone 15-deoxy-delta(12,14)-prostaglandin J2 inhibits G1/S transition and retinoblastoma protein phosphorylation in immortalized lymphocytes from Alzheimer's disease patients. | 2005 | Exp. Neurol. | pmid:16061222 |
Chen ZY and Tseng CC | 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. | 2005 | Mol. Pharmacol. | pmid:16077033 |
Chevalier E et al. | Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. | 2005 | J. Immunol. | pmid:16081770 |
Polikandriotis JA et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16020752 |
Kim J et al. | Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products. | 2005 | Cancer Res. | pmid:16024620 |
Choi YH et al. | New anti-inflammatory formulation containing Synurus deltoides extract. | 2005 | Arch. Pharm. Res. | pmid:16114500 |
Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
Mouihate A et al. | Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16037126 |
Nakae K et al. | Functional role of prostacyclin receptor in rat dorsal root ganglion neurons. | 2005 | Neurosci. Lett. | pmid:16039053 |
Gelir E et al. | Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16039105 |
Masini E et al. | Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic. | 2005 | Free Radic. Biol. Med. | pmid:16043023 |
Stahlschmidt J et al. | Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease. | 2005 | Kidney Int. | pmid:16105033 |
Appel S et al. | PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. | 2005 | Blood | pmid:16105976 |
Boyce JA | Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications. | 2005 | Chem Immunol Allergy | pmid:16107763 |
Hata AN et al. | Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2. | 2005 | J. Biol. Chem. | pmid:16030019 |
Motilva V et al. | COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. | 2005 | Int. Immunopharmacol. | pmid:15652766 |
MartÃnez B et al. | The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. | 2005 | J. Lipid Res. | pmid:15654126 |
Liang X et al. | Prostaglandin D2 mediates neuronal protection via the DP1 receptor. | 2005 | J. Neurochem. | pmid:15659218 |
O'Reilly KM et al. | Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15665045 |
Jerde TJ et al. | Celecoxib inhibits ureteral contractility and prostanoid release. | 2005 | Urology | pmid:15667901 |
Figarella K et al. | Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. | 2005 | Cell Death Differ. | pmid:15678148 |
Tanaka T et al. | Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. | 2005 | Eur. J. Pharmacol. | pmid:15680279 |
Genovese T et al. | Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. | 2005 | Eur. Respir. J. | pmid:15684285 |
Artwohl M et al. | Thiazolidinediones inhibit apoptosis and heat shock protein 60 expression in human vascular endothelial cells. | 2005 | Thromb. Haemost. | pmid:15886792 |
Malki S et al. | Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. | 2005 | EMBO J. | pmid:15889150 |
Wang Z and Figueiredo-Pereira ME | Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity. | 2005 | Mol. Cell. Neurosci. | pmid:15911346 |
Ishida A et al. | Characterization of cAMP-dependent proteolysis of GATA-6. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15913546 |
Hennersdorf F et al. | Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. | 2005 | Cell Res. | pmid:15916720 |
Hosoya T et al. | Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. | 2005 | J. Biol. Chem. | pmid:15917255 |
Andrews WJ et al. | Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862961 |
Allred CD and Kilgore MW | Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. | 2005 | Mol. Cell. Endocrinol. | pmid:15866424 |
Marzocco S et al. | The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. | 2005 | Intensive Care Med | pmid:15868139 |
Yoshida M et al. | Methotrexate suppresses inflammatory agonist induced interleukin 6 synthesis in osteoblasts. | 2005 | J. Rheumatol. | pmid:15868610 |
Li X et al. | Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. | 2005 | J. Rheumatol. | pmid:15868626 |
De Oliveira C et al. | Insulin alters nuclear factor-lambdaB and peroxisome proliferator-activated receptor-gamma protein expression induced by glycated bovine serum albumin in vascular smooth-muscle cells. | 2005 | J. Lab. Clin. Med. | pmid:15871306 |
Planagumà A et al. | The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. | 2005 | FASEB J. | pmid:15876570 |
Kim HY et al. | Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages. | 2005 | Immunol. Cell Biol. | pmid:15877607 |
Gallant MA et al. | Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. | 2005 | J. Bone Miner. Res. | pmid:15765187 |
Capobianco E et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. | 2005 | Reprod. Fertil. Dev. | pmid:15899154 |
Avis I et al. | Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. | 2005 | Cancer Res. | pmid:15899809 |
Costello DA et al. | Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. | 2005 | Neuropharmacology | pmid:15993441 |
Patel KM et al. | Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma). | 2005 | Cell. Signal. | pmid:15993751 |
Zurich MG et al. | Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. | 2005 | Neuroscience | pmid:15994020 |
Chacón P et al. | Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. | 2005 | Eur. J. Immunol. | pmid:15997464 |
Atkins KB et al. | Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15345487 |
Burgess HA et al. | PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15734787 |
Inoue K et al. | Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743408 |
Berry EB et al. | Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. | 2005 | Mol. Pharmacol. | pmid:15821150 |
Lindström TM and Bennett PR | 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15755849 |
Takashima T et al. | Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. | 2005 | Oncol. Rep. | pmid:15756430 |