PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kase K et al. | Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. | 2009 | Int. J. Mol. Med. | pmid:19212651 |
| Ricart KC et al. | The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. | 2009 | Biochem. J. | pmid:19161347 |
| Boehme SA et al. | Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). | 2009 | Int. Immunol. | pmid:19346259 |
| Wang WM et al. | PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. | 2009 | Acta Pharmacol. Sin. | pmid:19098936 |
| Bernardo A et al. | Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. | 2009 | J. Neuropathol. Exp. Neurol. | pmid:19535992 |
| Hironaka A et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19799872 |
| Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
| Kalogeromitros D et al. | A quercetin containing supplement reduces niacin-induced flush in humans. | 2008 Jul-Sep | Int J Immunopathol Pharmacol | pmid:18831918 |
| Papageorgiou E et al. | Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. | 2008 Jul-Aug | Mol. Med. | pmid:18475308 |
| Pettipher R and Hansel TT | Antagonists of the prostaglandin D2 receptor CRTH2. | 2008 Jul-Aug | Drug News Perspect. | pmid:18836589 |
| Takahashi N et al. | Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. | 2008 Jul-Aug | Channels (Austin) | pmid:18769139 |
| Tokuda H et al. | Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771907 |
| Wang S et al. | AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. | 2008 | Mol. Cell. Endocrinol. | pmid:18508192 |
| Curfs DM et al. | Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. | 2008 | J. Biol. Chem. | pmid:18511424 |
| Qiao L et al. | Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. | 2008 | Cancer Lett. | pmid:18477501 |
| Reddy RC et al. | Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. | 2008 | Blood | pmid:18535203 |
| Chana RS et al. | Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. | 2008 | Am. J. Nephrol. | pmid:18535368 |
| Tajima T et al. | Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). | 2008 | J. Pharmacol. Exp. Ther. | pmid:18492946 |
| Ghosh AK et al. | Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18627765 |
| Genovese T et al. | Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. | 2008 | Shock | pmid:18628687 |
| Alba G et al. | Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. | 2008 | J. Leukoc. Biol. | pmid:18515325 |
| Yoon HJ et al. | Regulation of TLR2 expression by prostaglandins in brain glia. | 2008 | J. Immunol. | pmid:18523308 |
| Bissonnette SL et al. | An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. | 2008 | J. Immunol. | pmid:18641309 |
| Qiao L et al. | Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. | 2008 | Mol. Cancer Ther. | pmid:18645029 |
| Ragolia L et al. | Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18619553 |
| Moreira V et al. | Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases. | 2008 | Toxicon | pmid:18619987 |
| Capobianco E et al. | Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. | 2008 | Mol. Hum. Reprod. | pmid:18621767 |
| Yang JH et al. | Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza. | 2008 | Arch. Pharm. Res. | pmid:19099230 |
| Dubourdeau M et al. | Opposite roles of STAT and PPARgamma in the induction of p21WAF1 expression by IL-13 in human peripheral blood monocytes. | 2008 | Eur. Cytokine Netw. | pmid:19103521 |
| Horváth B et al. | Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation. | 2008 | Neuroreport | pmid:18815586 |
| Fujimori K et al. | Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. | 2008 | Gene | pmid:18817855 |
| GarcÃa-Bueno B et al. | Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. | 2008 | Endocrinology | pmid:18079203 |
| Muñoz U et al. | On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. | 2008 | Cell. Mol. Life Sci. | pmid:18818877 |
| Hounoki H et al. | Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. | 2008 | Bone | pmid:18242157 |
| Zhao H et al. | Rubimetide (Met-Arg-Trp) derived from Rubisco exhibits anxiolytic-like activity via the DP1 receptor in male ddY mice. | 2008 | Peptides | pmid:18243414 |
| Ohinata K et al. | Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice. | 2008 | FEBS Lett. | pmid:18258196 |
| Perbandt M et al. | Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus. | 2008 | J. Mol. Biol. | pmid:18258257 |
| Kim EH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. | 2008 | Carcinogenesis | pmid:18192694 |
| Prenn C et al. | CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine. | 2008 | Pharmacology | pmid:18212515 |
| Rajakariar R et al. | Novel biphasic role for lymphocytes revealed during resolving inflammation. | 2008 | Blood | pmid:18218853 |
| Kuesap J et al. | Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18174022 |
| Crabb SJ et al. | BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. | 2008 | Oncol. Rep. | pmid:18288403 |
| Hong HY et al. | Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages. | 2008 | FEBS Lett. | pmid:18291107 |
| Giannini L et al. | Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs. | 2008 | J. Cell. Mol. Med. | pmid:18266975 |
| Malki S et al. | [Prostaglandin D2: new roles in the embryonic and pathological gonad]. | 2008 | Med Sci (Paris) | pmid:18272080 |
| Ono E et al. | Salicylamide-induced anaphylaxis: increased urinary leukotriene E4 and prostaglandin D2 metabolite. | 2008 | Allergy | pmid:18315738 |
| Hao GH et al. | Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts. | 2008 | Br. J. Pharmacol. | pmid:18278065 |
| Khan AH et al. | Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility. | 2008 | Eur. J. Pharmacol. | pmid:18177857 |
| Inoue T et al. | Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. | 2008 | Atherosclerosis | pmid:18436228 |
| Nomiya R et al. | CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. | 2008 | J. Immunol. | pmid:18390753 |