Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kim YI et al. | Effects of 15-deoxy-∆¹²,¹â´-prostaglandin Jâ‚‚ on the production of IL-8 and the expression of Toll-like receptor 2 in human primary keratinocytes stimulated with lipopolysaccharide. | 2011 | Mol. Biol. Rep. | pmid:20174873 |
Mor A et al. | Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release. | 2011 | Inflammation | pmid:20706780 |
Balzar S et al. | Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. | 2011 | Am. J. Respir. Crit. Care Med. | pmid:20813890 |
Menon R et al. | Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. | 2011 | Obstet Gynecol | pmid:21691170 |
Chowdhury AA et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21699992 |
Yamamoto Y et al. | Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. | 2011 | Am. J. Pathol. | pmid:21703412 |
Ulivi V et al. | Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. | 2011 | Arthritis Res. Ther. | pmid:21682897 |
Farhat A et al. | Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. | 2011 | J Ovarian Res | pmid:21352547 |
Yamamoto Y et al. | 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683069 |
Luker T et al. | Zwitterionic CRTh2 antagonists. | 2011 | J. Med. Chem. | pmid:21355602 |
Ayoub SS et al. | Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). | 2011 | Inflamm. Res. | pmid:21667309 |
Matsumoto T et al. | Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. | 2011 | Circ. J. | pmid:21325722 |
Cha B et al. | 15-deoxy-D12,14-prostaglandin J2 suppresses RANTES expression by inhibiting NADPH oxidase activation in Helicobacter pylori-infected gastric epithelial cells. | 2011 | J. Physiol. Pharmacol. | pmid:21673364 |
Wang P et al. | Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2. | 2011 | PLoS ONE | pmid:22096605 |
Maekawa N et al. | High-performance affinity purification for identification of 15-deoxy-Δ 12,14 -PGJ₂ interacting factors using magnetic nanobeads. | 2011 | Biomed. Chromatogr. | pmid:21374648 |
Kane CJ et al. | Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists. | 2011 | Brain Behav. Immun. | pmid:21376806 |
Arima M and Fukuda T | Prostaglandin Dâ‚‚ and T(H)2 inflammation in the pathogenesis of bronchial asthma. | 2011 | Korean J. Intern. Med. | pmid:21437156 |
Luna-Gomes T et al. | Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation. | 2011 | J. Immunol. | pmid:22102725 |
MartÃnez-Gras I et al. | The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. | 2011 | Schizophr. Res. | pmid:21334179 |
Zhao J et al. | Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. | 2011 | J. Clin. Invest. | pmid:22105170 |
Braciale TJ and Kim TS | Slowing down with age: lung DCs do it too. | 2011 | J. Clin. Invest. | pmid:22105176 |
Murata T et al. | Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22106279 |
Bräutigam K et al. | Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20878528 |
Alves C et al. | Effects of 15d-PGJâ‚‚-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. | 2011 | Br. J. Pharmacol. | pmid:20883476 |
Kanda N et al. | The antimycotic drugs itraconazole and terbinafine hydrochloride induce the production of human β-defensin-3 in human keratinocytes. | 2011 | Immunobiology | pmid:20875690 |
Liu H et al. | Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury. | 2011 | Neurobiol. Dis. | pmid:20933087 |
Moniot B et al. | Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. | 2011 | Dev. Dyn. | pmid:21887724 |
Hewson CA et al. | A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function. | 2011 | Clin. Exp. Allergy | pmid:21255156 |
Kanai Y et al. | Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue. | 2011 | J. Lipid Res. | pmid:21893678 |
He P et al. | Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. | 2011 | J. Biol. Chem. | pmid:21233206 |
Tao H and Hajri T | Very low density lipoprotein receptor promotes adipocyte differentiation and mediates the proadipogenic effect of peroxisome proliferator-activated receptor gamma agonists. | 2011 | Biochem. Pharmacol. | pmid:21924248 |
Kitz K et al. | 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. | 2011 | Free Radic. Biol. Med. | pmid:21236332 |
Hossain MS et al. | Development of enzyme-linked immunosorbent assay for Δ12-prostaglandin J2 and its application to the measurement of the endogenous product generated by cultured adipocytes during the maturation phase. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21237281 |
De Nuccio C et al. | Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. | 2011 | J. Neuropathol. Exp. Neurol. | pmid:21937914 |
Choi YH et al. | The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling. | 2011 | J. Biol. Chem. | pmid:21832046 |
Aung G et al. | Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. | 2011 | Immunology | pmid:21214543 |
Chowdhury AA et al. | Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21726533 |
Hovsepian E et al. | Modulation of inflammatory response and parasitism by 15-Deoxy-Δ(12,14) prostaglandin J(2) in Trypanosoma cruzi-infected cardiomyocytes. | 2011 | Int. J. Parasitol. | pmid:21215746 |
Song NY et al. | Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells. | 2011 | Chem. Res. Toxicol. | pmid:21728338 |
Cichocka-Jarosz E et al. | Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children. | 2011 | J Investig Allergol Clin Immunol | pmid:21721371 |
Wang JJ and Mak OT | Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGDâ‚‚ metabolite, 15d-PGJâ‚‚. | 2011 | Cell Biol. Int. | pmid:21999315 |
Seno T et al. | 15-Deoxy-Δ¹²,¹ⴠprostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. | 2011 | PLoS ONE | pmid:22003398 |
Matsushima Y et al. | Distinct roles of prostaglandin D2 receptors in chronic skin inflammation. | 2011 | Mol. Immunol. | pmid:21943706 |
Shinozawa T et al. | Tetranor PGDM analyses for the amyotrophic lateral sclerosis: positive and simple diagnosis and evaluation of drug effect. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22027143 |
Chang MC et al. | Antiplatelet effect by p-cresol, a uremic and environmental toxicant, is related to inhibition of reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. | 2011 | Atherosclerosis | pmid:21993412 |
de Jong E et al. | Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. | 2011 | PLoS ONE | pmid:21957481 |
Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
Urade Y and Hayaishi O | Prostaglandin D2 and sleep/wake regulation. | 2011 | Sleep Med Rev | pmid:22024172 |
Birbian N et al. | No association of PTGDR -441C/T polymorphism with asthma in a North Indian population. | 2011 | Dis. Markers | pmid:22182808 |
Wan CJ et al. | [PPARgamma agonists against respiratory syncytial virus infection in vitro study]. | 2011 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:22734242 |