| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Ascariasis | D001196 | 3 associated lipids |
| Thyroid Diseases | D013959 | 8 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Downard CD et al. | Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. | 1995 | Clin. Pharmacol. Ther. | pmid:7712673 |
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Parker CW et al. | Modulation of IL-4 production in murine spleen cells by prostaglandins. | 1995 | Cell. Immunol. | pmid:7720090 |
| Brouwer A et al. | Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin. | 1995 | Clin. Sci. | pmid:7720347 |
| Rodrigues M et al. | Synergistic antiplatelet action of nitric oxide (NO) with PGD2 and its metabolite PGJ2--relevance for cerebral circulation? | 1994 | J. Physiol. Pharmacol. | pmid:7727795 |
| Butterfield JH et al. | Aspirin idiosyncrasy in systemic mast cell disease: a new look at mediator release during aspirin desensitization. | 1995 | Mayo Clin. Proc. | pmid:7731260 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. | 1995 | Eur Arch Otorhinolaryngol | pmid:7734974 |
| Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
| Imamura Y et al. | Mechanism of phospholipase D activation induced by prostaglandin D2 in osteoblast-like cells: function of Ca2+/calmodulin. | 1995 | Cell. Signal. | pmid:7756110 |
| Hashimoto N et al. | Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate. | 1995 | Hepatology | pmid:7768516 |
| Pilbeam CC et al. | Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. | 1995 | J. Bone Miner. Res. | pmid:7785462 |
| Johnston SL et al. | Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor. | 1995 | Eur. Respir. J. | pmid:7789486 |
| Guh JH et al. | Antiplatelet effect of gingerol isolated from Zingiber officinale. | 1995 | J. Pharm. Pharmacol. | pmid:7791032 |
| Lanas AI et al. | Non-steroidal anti-inflammatory drugs and prostaglandin effects on pepsinogen secretion by dispersed human peptic cells. | 1995 | Gut | pmid:7797113 |
| Grewe M et al. | Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. | 1995 | J. Invest. Dermatol. | pmid:7798637 |
| Pons F et al. | Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7813544 |
| Hoffmann R et al. | Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. | 1994 | J. Hepatol. | pmid:7814800 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Spatz M et al. | Vasoactive peptides and prostaglandin D2 in human cerebromicrovascular endothelium. | 1994 | J. Auton. Nerv. Syst. | pmid:7836668 |
| Moussard C et al. | Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846109 |
| van Haaster CM et al. | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases. | 1995 | Biochim. Biophys. Acta | pmid:7857988 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Polosa R et al. | Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881647 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
| Minami T et al. | Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. | 1994 | Pain | pmid:7916452 |
| Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
| Kantha SS | Histamine-interleukin-prostaglandin pathway: a hypothesis for a biochemical cycle regulating sleep and wakefulness. | 1994 | Med. Hypotheses | pmid:7935077 |
| Ohara H et al. | Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme. | 1994 | Biochim. Biophys. Acta | pmid:7948008 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965770 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965771 |
| Hirata M et al. | Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972033 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. | 1994 | Arch Dermatol | pmid:7979442 |
| Lahaye DH et al. | Effect of bradykinin on loss of density-dependent growth inhibition of normal rat kidney cells. | 1994 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:7981625 |
| Toth P et al. | Administration of human chorionic gonadotropin affects sleep-wake phases and other associated behaviors in cycling female rats. | 1994 | Brain Res. | pmid:7987667 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Athari A et al. | Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. | 1994 | Hepatology | pmid:8020883 |
| Touqui L et al. | Excretion of platelet activating factor-acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: possible role in the regulation of platelet activating factor release. | 1994 | J. Allergy Clin. Immunol. | pmid:8027488 |
| Murphy PJ et al. | Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. | 1994 | Physiol. Behav. | pmid:8047572 |
| Peden DB et al. | Hydrogen peroxide effects on rat mast cell function. | 1994 | Am. J. Physiol. | pmid:8048546 |
| Sakuma S et al. | Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048918 |
| Nishizawa EE et al. | Prostaglandin d2 as a potential antithrombotic agent. | 1975 | Prostaglandins | pmid:806102 |
| Gotoh M et al. | Desensitization of prostaglandin F2 alpha receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes. | 1994 | Neurochem. Res. | pmid:8065525 |
| Murakami M et al. | Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. | 1994 | J. Biol. Chem. | pmid:8071353 |
| Tran-Thi TA et al. | Effects of hypoxia on the oxygen-dependent metabolism of prostaglandins and adenosine in liver cells. | 1994 | J. Hepatol. | pmid:8071531 |
| Chen WY et al. | The effect of 3-[2-(cyclopropylamino)ethoxy]xanthone on platelet thromboxane formation. | 1994 | Thromb. Res. | pmid:8073410 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Kitanaka J et al. | Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes. | 1993 | J. Neurochem. | pmid:8093482 |
| Twentyman OP et al. | The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8099592 |
| Tudorić N et al. | Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. | 1994 | Int. Arch. Allergy Immunol. | pmid:8111247 |
| Grunnet N et al. | Absence of glycogen cycling in cultured rat hepatocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8117107 |