| MeSH term | MeSH ID | Detail |
|---|---|---|
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Ascariasis | D001196 | 3 associated lipids |
| Thyroid Diseases | D013959 | 8 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kojima K et al. | Effect of PPARgamma ligands on the viability of gastric epithelial cells. | 2002 | Aliment. Pharmacol. Ther. | pmid:11966526 |
| Cuzzocrea S et al. | The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation. | 2002 | Mol. Pharmacol. | pmid:11961117 |
| Natarajan C and Bright JJ | Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. | 2002 | Genes Immun. | pmid:11960303 |
| Finck BN and Johnson RW | Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11959686 |
| Nosjean O and Boutin JA | Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? | 2002 | Cell. Signal. | pmid:11955950 |
| Nishida K et al. | Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. | 2002 | Br. J. Cancer | pmid:11953889 |
| Pestel S et al. | Inhibition by prostaglandin E(2) of anaphylatoxin C5a- but not zymosan-induced prostanoid release from rat Kupffer cells. | 2002 | Lab. Invest. | pmid:11950903 |
| Shimada T et al. | Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. | 2002 | Gut | pmid:11950812 |
| Mujumdar VS et al. | Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11940516 |
| Hong JT et al. | Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. | 2002 | J. Toxicol. Environ. Health Part A | pmid:11936221 |
| Quraishi O et al. | Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids. | 2002 | Biochem. Pharmacol. | pmid:11931852 |
| Bochenek G et al. | [Prostaglandin D2: biosynthesis, biological properties and participation in bronchial asthma]. | 2001 | Pol. Arch. Med. Wewn. | pmid:11928572 |
| Nicolaidis S et al. | [Variations of hypothalamic and cortical prostaglandins and monoamines reveal transitions in arousal states: microdialysis study in the rat]. | 2001 | Rev. Neurol. (Paris) | pmid:11924034 |
| Mondoro TH and Vostal JG | Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents. | 2002 | Platelets | pmid:11918832 |
| Rovin BH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death. | 2002 | Kidney Int. | pmid:11918736 |
| Xie S et al. | 15 deoxy delta12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells. | 2002 | Thromb. Haemost. | pmid:11916086 |
| Monneret G et al. | 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. | 2002 | J. Immunol. | pmid:11907120 |
| Whigham LD et al. | Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893615 |
| González E et al. | Streptozotocin-pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. | 2002 | Nitric Oxide | pmid:11890746 |
| Büyükgüzel K et al. | Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta. | 2002 | Insect Biochem. Mol. Biol. | pmid:11886778 |
| Mellor EA et al. | Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. | 2002 | J. Exp. Med. | pmid:11877481 |
| Adams IR and McLaren A | Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis. | 2002 | Development | pmid:11874911 |
| Takano H and Komuro I | Roles of peroxisome proliferator-activated receptor gamma in cardiovascular disease. | 2002 Jan-Feb | J. Diabetes Complicat. | pmid:11872377 |
| Fahmi H et al. | Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. | 2002 | Osteoarthr. Cartil. | pmid:11869069 |
| Harris SG et al. | Prostaglandins as modulators of immunity. | 2002 | Trends Immunol. | pmid:11864843 |
| Kwak BR et al. | PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. | 2002 | Circ. Res. | pmid:11861426 |
| Diab A et al. | Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. | 2002 | J. Immunol. | pmid:11859145 |
| Masamune A et al. | Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. | 2002 | Pancreas | pmid:11854617 |
| Harris SG and Phipps RP | Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. | 2002 | Immunology | pmid:11849312 |
| Hayaishi O and Urade Y | Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. | 2002 | Neuroscientist | pmid:11843094 |
| Pizzimenti S et al. | Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation. | 2002 | Free Radic. Biol. Med. | pmid:11827749 |
| Michimata T et al. | Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner. | 2002 | Mol. Hum. Reprod. | pmid:11818521 |
| Dieter P et al. | Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. | 2002 | Cell. Signal. | pmid:11812647 |
| Cheuk BL et al. | Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. | 2002 | Biol. Reprod. | pmid:11804951 |
| Diaz BL et al. | Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. | 2002 | J. Immunol. | pmid:11801681 |
| Harris SG et al. | 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. | 2002 | J. Immunol. | pmid:11801678 |
| Hirai H et al. | Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. | 2002 | J. Immunol. | pmid:11801628 |
| Hayaishi O | Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. | 2002 | J. Appl. Physiol. | pmid:11796702 |
| Shibata T et al. | 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. | 2002 | J. Biol. Chem. | pmid:11786541 |
| Keelan J et al. | 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785780 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Fu Y et al. | Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. | 2002 | Atherosclerosis | pmid:11755918 |
| Yagami T et al. | Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. | 2002 | Mol. Pharmacol. | pmid:11752212 |
| Fujitani Y et al. | Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. | 2002 | J. Immunol. | pmid:11751991 |
| Schoppee PD et al. | Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. | 2002 | Biol. Reprod. | pmid:11751282 |
| Noverr MC et al. | Production of prostaglandins and leukotrienes by pathogenic fungi. | 2002 | Infect. Immun. | pmid:11748207 |
| Reilly TP et al. | A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. | 2001 | Chem. Res. Toxicol. | pmid:11743745 |
| Simonin MA et al. | PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11742805 |
| Gervais FG et al. | Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. | 2001 | J. Allergy Clin. Immunol. | pmid:11742277 |
| Pignatelli M et al. | The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. | 2001 | J. Cell. Sci. | pmid:11739643 |