| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fetal Weight | D020567 | 12 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Urticaria | D014581 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miwa Y et al. | Physiology and pharmacology of the prostaglandin J2 family. | 2004 | Nippon Yakurigaku Zasshi | pmid:14695456 |
| Fernández-Tome M et al. | COX-2-mediated PGD2 synthesis regulates phosphatidylcholine biosynthesis in rat renal papillary tissue. | 2004 | Biochem. Pharmacol. | pmid:14698037 |
| Matsuo T et al. | 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741709 |
| Józkowicz A et al. | Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14715242 |
| Neuhofer W et al. | Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. | 2004 | Kidney Int. | pmid:14717913 |
| Ward JE et al. | PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. | 2004 | Br. J. Pharmacol. | pmid:14718259 |
| Ray DM et al. | Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. | 2004 | Clin. Immunol. | pmid:15451478 |
| Abraha D et al. | (S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model. | 2004 | Int. Arch. Allergy Immunol. | pmid:15031612 |
| Rodway HA et al. | Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells. | 2004 | Biochem. J. | pmid:15171682 |
| Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
| Kumagai M et al. | 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells. | 2004 | Tohoku J. Exp. Med. | pmid:14998300 |
| Emi M and Maeyama K | The biphasic effects of cyclopentenone prostaglandins, prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2) on proliferation and apoptosis in rat basophilic leukemia (RBL-2H3) cells. | 2004 | Biochem. Pharmacol. | pmid:15013841 |
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| Paumi CM et al. | Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). | 2004 | Biochemistry | pmid:14979731 |
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