| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fetal Weight | D020567 | 12 associated lipids |
| Blood Platelet Disorders | D001791 | 12 associated lipids |
| Liver Cirrhosis, Biliary | D008105 | 12 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Urticaria | D014581 | 13 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Georgitis JW et al. | Nasal inflammatory mediator release in ragweed allergic rhinitis: correlation with cellular influx into nasal secretions. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1666629 |
| Takayanagi I et al. | Effects of aging on alpha 2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations. | 1991 | Eur. J. Pharmacol. | pmid:1674919 |
| Goerg KJ et al. | Antisecretory effect of prostaglandin D2 in rat colon in vitro: action sites. | 1991 | Am. J. Physiol. | pmid:1676243 |
| Fox CC et al. | Modulation of mediator release from human intestinal mast cells by sulfasalazine and 5-aminosalicylic acid. | 1991 | Dig. Dis. Sci. | pmid:1703070 |
| Massey WA et al. | Profile of prostanoid release following antigen challenge in vivo in the skin of man. | 1991 | Br. J. Dermatol. | pmid:1760357 |
| Shikada K et al. | NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea. | 1991 | Eur. J. Pharmacol. | pmid:1814761 |
| Gaetani P et al. | Effect of high-dose methylprednisolone and U74006F on eicosanoid synthesis after subarachnoid hemorrhage in rats. | 1991 | Stroke | pmid:1900645 |
| Weiler H et al. | Studies on the effects of aminopterin and methotrexate on the release of prostaglandin PGE2, PGD2, and PGI2 from small intestine in the rat in vivo. | 1991 | Clin. Chim. Acta | pmid:1769112 |
| Watanabe T et al. | Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. | 1991 | Blood | pmid:1718495 |
| Minc-Golomb D et al. | Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice. | 1991 | EMBO J. | pmid:1829676 |
| Vesin MF et al. | Preferential synthesis of prostaglandin D2 by neurons and prostaglandin E2 by fibroblasts and nonneuronal cells in chick dorsal root ganglia. | 1991 | J. Neurochem. | pmid:2051162 |
| Ramis I et al. | In vivo release of 15-HETE and other arachidonic acid metabolites in nasal secretions during early allergic reactions. | 1991 | Prostaglandins | pmid:1662405 |
| Fukushima M | [Prostaglandins and cell proliferation]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024021 |
| White MV et al. | Hydrocortisone inhibits rat basophilic leukemia cell mediator release induced by neutrophil-derived histamine releasing activity as well as by anti-IgE. | 1991 | J. Immunol. | pmid:1712816 |
| Walmrath D et al. | Intravascular anti-IgE challenge in perfused lungs: mediator release and vascular pressor response. | 1991 | J. Appl. Physiol. | pmid:1723406 |
| Vesin MF and Droz B | Biosynthesis of prostaglandins D2 and E2 in chick dorsal root ganglion during development. | 1991 | J. Neurochem. | pmid:1904909 |
| Misawa M and Kanai Y | Effect of the new antiallergic drug epinastine on chemical mediator induced bronchoconstrictions in guinea pigs. | 1991 | Arzneimittelforschung | pmid:1725697 |
| Abman SH and Accurso FJ | Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. | 1991 | Am. J. Physiol. | pmid:1847014 |
| Sladek K et al. | Formation of PGD2 after allergen inhalation in atopic asthmatics. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1847781 |
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| Atsmon J et al. | Modulation of the antiproliferative activity of 9-deoxy-delta 9,delta 12(E)-PGD2 by conjugation with intracellular glutathione. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825432 |
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| Koizumi K et al. | Induction of 31,000 protein by PGD2-treated vascular endothelial cells. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825433 |
| Morrow JD et al. | A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825560 |
| Howarth P et al. | The comparative nasal effects of prostaglandin D2 in normal and rhinitic subjects. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825579 |
| Gundel RH et al. | The effects of a 5-lipoxygenase inhibitor on antigen-induced mediator release, late-phase bronchoconstriction and cellular infiltrates in primates. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825582 |
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| King KL et al. | Metabolism of arachidonic acid by isolated rabbit ciliary epithelium. | 1992 | Exp. Eye Res. | pmid:1426059 |
| Thomas PS et al. | Tobacco smoke releases performed mediators from canine mast cells and modulates prostaglandin production. | 1992 | Am. J. Physiol. | pmid:1636731 |
| Sasaguri T et al. | Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression. | 1992 | Exp. Cell Res. | pmid:1572402 |
| Sinzinger H et al. | Isradipine improves platelet function in hypertensives. | 1992 | Eur. J. Clin. Pharmacol. | pmid:1531796 |
| Ito S et al. | Type-1 and type-2 astrocytes are distinct targets for prostaglandins D2, E2, and F2 alpha. | 1992 | Glia | pmid:1324890 |
| Tsukagoshi H and Kurosawa M | [Bronchial hyperresponsiveness to histamine induced by intravenous administration of prostaglandin D2 (PGD2) in guinea pigs]. | 1992 | Nippon Yakurigaku Zasshi | pmid:1559641 |
| Magnussen H et al. | Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction. | 1992 | J. Allergy Clin. Immunol. | pmid:1535083 |
| Gaetani P et al. | Ex vivo release of eicosanoids after aneurysmal subarachnoid hemorrhage: a preliminary experience in humans. | 1992 | Acta Neurol. Scand. | pmid:1414230 |
| Katz HR et al. | Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. | 1992 | J. Immunol. | pmid:1309842 |
| Okayama Y et al. | Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine. | 1992 | Clin. Exp. Allergy | pmid:1375128 |
| Okayama Y and Church MK | Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. | 1992 | Int. Arch. Allergy Immunol. | pmid:1375203 |
| Smith JB et al. | Cyclic AMP does not inhibit collagen-induced platelet signal transduction. | 1992 | Biochem. J. | pmid:1375452 |
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| Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
| Lippton HL et al. | Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed. | 1992 | Am. J. Physiol. | pmid:1348400 |
| Crea AE et al. | Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma. | 1992 | Eur. Respir. J. | pmid:1348480 |
| Shin MH et al. | The effect of azelastine on the early allergic response. | 1992 | Clin. Exp. Allergy | pmid:1349259 |
| Molderings G et al. | Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype. | 1992 | Br. J. Pharmacol. | pmid:1330175 |
| Mulkins MA et al. | Mycophenolic acid inhibits the degranulation of rat peritoneal mast cells. | 1992 | Cell. Immunol. | pmid:1349511 |
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