PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Zollinger-Ellison Syndrome D015043 1 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Loss D015431 56 associated lipids
Leukemia, B-Cell D015448 3 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
HTLV-I Infections D015490 3 associated lipids
Nasal Obstruction D015508 4 associated lipids
Choroid Diseases D015862 2 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Coronavirus Infections D018352 4 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Vasculitis, Leukocytoclastic, Cutaneous D018366 5 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Muhammad SN et al. 15d-PGJ2 Induces Apoptosis of MCF-7 and MDA-MB-231 Cells via Increased Intracellular Calcium and Activation of Caspases, Independent of ERα and ERβ. 2016 Asian Pac. J. Cancer Prev. pmid:27509924
Murata T and Maehara T Discovery of anti-inflammatory role of prostaglandin D2. 2016 J. Vet. Med. Sci. pmid:27498997
Tsujimoto S et al. Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. 2016 Int. J. Mol. Med. pmid:27431935
Feng X et al. Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease. 2016 J. Allergy Clin. Immunol. pmid:27423494
Nelson SM et al. Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic Helminth Nippostrongylus brasiliensis. 2016 J. Biol. Chem. pmid:26644468
Zhou Q et al. Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis. 2016 Am. J. Respir. Cell Mol. Biol. pmid:26488390
Doig CL et al. Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells. 2016 J. Steroid Biochem. Mol. Biol. pmid:26429394
Wang M et al. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. 2016 Life Sci. pmid:26808090
de Melo NF et al. 15d-PGJ2-Loaded Solid Lipid Nanoparticles: Physicochemical Characterization and Evaluation of Pharmacological Effects on Inflammation. 2016 PLoS ONE pmid:27575486
Li WY et al. Effect of 15-Deoxy-â–³(12,14)-prostaglandin J2 on Expression of Macrophage Migration Inhibitory Factor in Mouse Monocyte/macrophage Cell Line J774A.1. 2016 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:27544994
Kim HJ et al. ROSics: chemistry and proteomics of cysteine modifications in redox biology. 2015 Mar-Apr Mass Spectrom Rev pmid:24916017
Le Loupp AG et al. [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. 2015 Jun-Jul Med Sci (Paris) pmid:26152165
Busse WW et al. Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control. 2015 Chest pmid:26226215
Tsutsumi S et al. Cerebrospinal fluid drainage through the diploic and spinal epidural veins. 2015 J. Anat. pmid:26184099
Jeon KI et al. Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts. 2015 Exp. Eye Res. pmid:26142957
Cossette C et al. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. 2015 Biochem. Pharmacol. pmid:26032638
Guan PP et al. The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. 2015 Sci Rep pmid:25992485
Tang F et al. Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells. 2015 Mediators Inflamm. pmid:25960618
Rossitto M et al. Multiple roles of the prostaglandin D2 signaling pathway in reproduction. 2015 Reproduction pmid:25269616
Hyun J et al. Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. 2015 J Innate Immun pmid:25171731