PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Bronchial Hyperreactivity D016535 15 associated lipids
Encephalitis D004660 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Astrocytoma D001254 15 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
HIV Seropositivity D006679 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Blister D001768 16 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Haack M et al. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. 2007 Sleep pmid:17910386
Abdelrahman M et al. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. 2004 Shock pmid:15545828
Hickson-Bick DL et al. The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. 2006 Shock pmid:16680021
Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
Genovese T et al. Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. 2008 Shock pmid:18628687
Monroy MA et al. THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. 2007 Shock pmid:17510607
Zingarelli B et al. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. 2007 Shock pmid:17589386
Guyton K et al. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. 2003 Shock pmid:12813370
Kaplan J et al. Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. 2007 Shock pmid:17621259
Kaplan JM et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. 2005 Shock pmid:15988322
Piraino G et al. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. 2006 Shock pmid:16878022
Hovsepian E et al. 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. 2010 Shock pmid:19997048
Yeh CH et al. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. 2006 Shock pmid:16912651
Li LH and Ku BS [Regulation of SWS by hormones and cytokines]. 2000 Sheng Li Ke Xue Jin Zhan pmid:12532764
Moniot B et al. Male specific expression of lipocalin-type prostaglandin D synthase (cPTGDS) during chicken gonadal differentiation: relationship with cSOX9. 2008 Sex Dev pmid:18577876
Watanabe K [PGF synthetase]. 1986 Seikagaku pmid:3084680
Shibata T and Uchida K [Current opinions on prostaglandin J2]. 2005 Seikagaku pmid:16241007
Inoué S [Sleep substances: their roles and evolution]. 1983 Seikagaku pmid:6355327
Satoh T [Cysteine-mediated signaling pathway by a novel electrophilic compound, NEPP11]. 2007 Seikagaku pmid:17319510
Watanabe K [Structure and function of prostaglandin F synthetase]. 1989 Seikagaku pmid:2693551
Matsuoka T et al. Prostaglandin D2 as a mediator of allergic asthma. 2000 Science pmid:10720327
Kalgutkar AS et al. Aspirin-like molecules that covalently inactivate cyclooxygenase-2. 1998 Science pmid:9596581
Dutta-Roy AK et al. Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. 1986 Science pmid:3001935
Garza LA et al. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. 2012 Sci Transl Med pmid:22440736
Okuyama S and Mishina H Principia of cancer therapy. X. Prostaglandin D2 triggers redifferentiation of the bestatin-treated breast cancer cells in vitro. 1985 Sci Rep Res Inst Tohoku Univ Med pmid:3870142
Okuyama S and Mishina H Principia of cancer therapy. XI. Prostaglandin D2 induces redifferentiation of M1 leukemia cells in vitro irrespective of bestatin. 1985 Sci Rep Res Inst Tohoku Univ Med pmid:3870143
Ma J et al. Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload. 2016 Sci Rep pmid:27089935
Shibata T et al. Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. 2016 Sci Rep pmid:26879669
Yoon YS et al. Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF. 2016 Sci Rep pmid:26875548
Guan PP et al. The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. 2015 Sci Rep pmid:25992485
Fredman G et al. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. 2012 Sci Rep pmid:22957142
Martínez-Gras I et al. The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. 2011 Schizophr. Res. pmid:21334179
Ward PE et al. Niacin skin flush in schizophrenia: a preliminary report. 1998 Schizophr. Res. pmid:9516668
Martinez-Cengotitabengoa M et al. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. 2016 Schizophr Bull pmid:26130821
García-Bueno B et al. Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. 2014 Schizophr Bull pmid:23486748
Csala M et al. Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. 1998 Scand. J. Immunol. pmid:9743211
Goto H et al. The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. 1989 Scand. J. Gastroenterol. Suppl. pmid:2595317
Aschenbach JR et al. Functional characteristics of the porcine colonic epithelium following transportation stress and Salmonella infection. 2007 Scand. J. Gastroenterol. pmid:17505993
Salińska E et al. Role of Ca2+ release from ryanodine stores in generation of NMDA-induced Ca2+ signal in rabbit hippocampus. 1999 Ross Fiziol Zh Im I M Sechenova pmid:10389178
Gaetani P et al. [Prostaglandin D2 in subarachnoid hemorrhage. Biological and diagnostic implications]. 1983 Jul-Aug Riv Patol Nerv Ment pmid:6598516
Hayaishi O [The brain and prostaglandins]. 1983 Rinsho Shinkeigaku pmid:6587956
Ji JD et al. Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. 2005 Rheumatology (Oxford) pmid:15840591
Jakob M et al. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. 2004 Rheumatology (Oxford) pmid:15113997
Nicolaidis S et al. [Variations of hypothalamic and cortical prostaglandins and monoamines reveal transitions in arousal states: microdialysis study in the rat]. 2001 Rev. Neurol. (Paris) pmid:11924034
Dorta-Contreras AJ et al. [Beta trace protein in the cerebrospinal fluid and serum in meningoencephalitis]. 1998 Rev Neurol pmid:9585948
Carsin A et al. [Physiopathology of aspirin intolerant asthma]. 2012 Rev Mal Respir pmid:22405107
Mendoza Magaña MJ et al. [Anaphylaxis and anaphylactic shock]. 2007 Mar-Apr Rev Alerg Mex pmid:17542244
Qiu Z et al. Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux. 2011 Respirology pmid:21342332
Miadonna A et al. Mediators and allergic inflammation of human airways. 1988 Respiration pmid:2466314
Peters SP et al. The pharmacologic control of mediator release from human basophils and mast cells. 1986 Respiration pmid:3494282