PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Astrocytoma D001254 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
HIV Seropositivity D006679 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Encephalitis D004660 15 associated lipids
Blister D001768 16 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Ueta M et al. PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. 2004 Kidney Int. pmid:14871416
Chung YW et al. [Effects of peroxisome proliferator-activated receptor-gamma agonist on Fas-mediated apoptosis in HT-29 cells]. 2003 Korean J Gastroenterol pmid:14532729
Arima M and Fukuda T Prostaglandin Dâ‚‚ and T(H)2 inflammation in the pathogenesis of bronchial asthma. 2011 Korean J. Intern. Med. pmid:21437156
Pestel S et al. Inhibition by prostaglandin E(2) of anaphylatoxin C5a- but not zymosan-induced prostanoid release from rat Kupffer cells. 2002 Lab. Invest. pmid:11950903
Meuten DJ et al. Hypercalcemia in dogs with adenocarcinoma derived from apocrine glands of the anal sac. Biochemical and histomorphometric investigations. 1983 Lab. Invest. pmid:6300551
Michel L et al. Prostaglandin D2 generation in mouse bone marrow-derived mast cells exposed to dexamethasone is associated with endogenous peroxidase activity. 1988 Lab. Invest. pmid:2460694
Okano H et al. 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. 2003 Lab. Invest. pmid:14563954
Relic B et al. Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. 2009 Lab. Invest. pmid:19434061
Iikura M et al. IL-33 can promote survival, adhesion and cytokine production in human mast cells. 2007 Lab. Invest. pmid:17700564
Naclerio RM et al. The effect of cetirizine on early allergic response. 1989 Laryngoscope pmid:2566879
Tsao CJ et al. In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. 1986 Leuk. Res. pmid:3012210
Zang C et al. Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia. 2004 Leuk. Res. pmid:15109539
Hayden RE et al. Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. 2009 Leukemia pmid:18923439
D'Onofrio C et al. Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction. 1994 Leukemia pmid:7516027
Hughes-Fulford M and Fukushima M Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism. 1993 Life Sci Adv Exp Clin Endocrinol pmid:11539936
Narumiya S et al. Prostaglandin D2 in rat brain, spinal cord and pituitary: basal level and regional distribution. 1982 Life Sci. pmid:6960222
Kang MA et al. Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells. 2007 Life Sci. pmid:17161435
Chen GG et al. Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer. 2002 Life Sci. pmid:12269390
Weidenbach H et al. Reduction of bile secretion by prostaglandins in the rat in vivo. 1996 Life Sci. pmid:8649182
Wung BS et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) suppresses IL-6-induced STAT3 phosphorylation via electrophilic reactivity in endothelial cells. 2006 Life Sci. pmid:16413037
Barreto EO et al. High levels of filamentous actin and apoptosis correlate with mast cell refractoriness under alloxan-evoked diabetes. 2006 Life Sci. pmid:16647092
Tanaka T et al. Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. 2001 Life Sci. pmid:11693274
Shalit M et al. New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. 1986 Life Sci. pmid:3018403
Simpkins CO et al. Prostaglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl. 1990 Life Sci. pmid:2319907
Kanamori Y et al. Migration of neutrophils from blood to tissue: alteration of modulatory effects of prostanoid on superoxide generation in rabbits and humans. 1997 Life Sci. pmid:9096262
Shirahase H et al. Inhibitory effects of PGD2, PGJ2 and 15-deoxy-delta12,14-PGJ2 on iNOS induction in rat mesenteric artery. 2000 Life Sci. pmid:10834301
Negoro H et al. Endogenous prostaglandin D(2) synthesis decreases vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells. 2005 Life Sci. pmid:16154157
Liu JD et al. Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. 2004 Life Sci. pmid:14998722
Marone G et al. Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion. 1989 Life Sci. pmid:2480501
Clemente-Napimoga JT et al. 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. 2012 Life Sci. pmid:22564409
Jung WK et al. The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. 2009 Life Sci. pmid:19409914
Kattamuri PV et al. Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity. 2013 Life Sci. pmid:22820546
Berryman GK et al. Amniotic fluid prostaglandin D2 in spontaneous and augmented labor. 1987 Life Sci. pmid:3476816
Wang M et al. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. 2016 Life Sci. pmid:26808090
Brose SA et al. A fast one-step extraction and UPLC-MS/MS analysis for E2/D 2 series prostaglandins and isoprostanes. 2013 Lipids pmid:23400687
Yoo JM et al. Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. 2013 Lipids pmid:23377981
Zuckerman SH et al. The effect of gamma-interferon to inhibit macrophage-high density lipoprotein interactions is reversed by 15-deoxy-delta12,14-prostaglandin J2. 2000 Lipids pmid:11132183
Date M et al. 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells. 2003 Liver Int. pmid:14986820
Gressner OA et al. Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. 2009 Liver Int. pmid:19018984
Walls AF et al. Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction. 1991 Lung pmid:1921474
Kim HJ et al. ROSics: chemistry and proteomics of cysteine modifications in redox biology. 2015 Mar-Apr Mass Spectrom Rev pmid:24916017
Kudoh I et al. [Prostanoids and acute lung injury]. 2002 Masui pmid:12134647
Kushikata T et al. [Sleep and anesthesia--Part 1, Recent findings in research]. 2007 Masui pmid:17877045
Amano N [Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats]. 1987 Masui pmid:3480360
Butterfield JH et al. Aspirin idiosyncrasy in systemic mast cell disease: a new look at mediator release during aspirin desensitization. 1995 Mayo Clin. Proc. pmid:7731260
Uchida K Induction of glutathione S-transferase by prostaglandins. 2000 Mech. Ageing Dev. pmid:10996013
Nozaki Y et al. PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. 2013 Med Mol Morphol pmid:23397546
Le Loupp AG et al. [Dual role for prostaglandin D2 in intestinal epithelial homeostasis]. 2015 Jun-Jul Med Sci (Paris) pmid:26152165
Malki S et al. [Prostaglandin D2: new roles in the embryonic and pathological gonad]. 2008 Med Sci (Paris) pmid:18272080
Kantha SS Histamine-interleukin-prostaglandin pathway: a hypothesis for a biochemical cycle regulating sleep and wakefulness. 1994 Med. Hypotheses pmid:7935077