| MeSH term | MeSH ID | Detail |
|---|---|---|
| Astrocytoma | D001254 | 15 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Dyskinesia, Drug-Induced | D004409 | 15 associated lipids |
| HIV Seropositivity | D006679 | 15 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Adenomatous Polyposis Coli | D011125 | 16 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
| Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
| Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
| Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
| pmid:29402808 | ||||
| pmid:29463843 | ||||
| Frölich JC et al. | Advances in the analysis of eicosanoids by ELISA and GC/MS/MS. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949561 |
| Tilden SJ et al. | Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2. | 1987 | J. Appl. Physiol. | pmid:2954941 |
| Seibert K et al. | 9 alpha, 11 beta-prostaglandin F2: formation and metabolism by human lung and contractile effects on human bronchial smooth muscle. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959045 |
| Roberts LJ et al. | PGD2 is transformed by human coronary arteries to 9 alpha, 11 beta-PGF2, which contracts human coronary artery rings. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959090 |
| Watanabe K et al. | Stereospecific conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and prostaglandin H2 to prostaglandin F2 alpha by PGF synthetase. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959094 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds: a new family of eicosanoids produced in vivo in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959099 |
| Pugliese G et al. | 9 alpha, 11 beta-prostaglandin F2: a new prostanoid with selective biosynthesis and unique biological activity. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959104 |
| Robinson C et al. | Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960146 |
| Roberts LJ | Recent metabolic findings bring into question the reliability of existing methods for quantification of PGF2 alpha and its metabolites in human biological fluids. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960165 |
| Prakash C et al. | Synthesis of putative prostaglandin D2 metabolites. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960191 |
| Watanabe Y et al. | Synthesis of 11C-labeled prostaglandins and positron emission tomography studies using the rhesus monkey. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960207 |
| Hayaishi O et al. | Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960208 |
| Narumiya S and Fukushima M | Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960214 |
| Ono K et al. | Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960215 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Bhattacharya SK and Parmar SS | Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. | 1987 | Pharm. Res. | pmid:2977646 |
| Robinson C and Holgate ST | Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. | 1985 | Clin. Sci. | pmid:2981650 |
| Westcott JY and Murphy RC | Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:2982416 |
| Imashuku S et al. | Tumor differentiation--application of prostaglandins in the treatment of neuroblastoma. | 1985 | Prog. Clin. Biol. Res. | pmid:2986176 |
| Makino S | [Physiological and pharmacological actions of prostaglandins and related substances: inflammation and allergy]. | 1985 | Nippon Rinsho | pmid:2989584 |
| Siegl AM and Daly JW | Receptor (norepinephrine), P-site (2',5'-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cyclic AMP-generating systems in human platelets. | 1985 | J Cyclic Nucleotide Protein Phosphor Res | pmid:2991349 |
| Förstermann U et al. | Studies on the mechanism of central cardiovascular and temperature responses to prostaglandin D2. | 1985 | Prostaglandins Leukot Med | pmid:2991946 |
| Hamid S and Whittle BJ | Interaction of prostaglandin D2 with prostacyclin, carbacyclin and the hydantoin prostaglandin, BW245C, in guinea-pig platelets. | 1985 | Br. J. Pharmacol. | pmid:2992652 |
| Narumiya S and Toda N | Different responsiveness of prostaglandin D2-sensitive systems to prostaglandin D2 and its analogues. | 1985 | Br. J. Pharmacol. | pmid:2992661 |
| Watanabe Y et al. | Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. | 1985 | Brain Res. | pmid:2994820 |
| Bertelé V et al. | Refractoriness of platelets to prostaglandins after infusion in rabbits. | 1985 | J. Lab. Clin. Med. | pmid:2997353 |
| Dutta-Roy AK et al. | Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. | 1986 | Science | pmid:3001935 |
| Fortini A et al. | Heparin does not interfere with prostacyclin and prostaglandin D2 binding to platelets. | 1985 | Thromb. Res. | pmid:3001968 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
| Ichikawa A et al. | Up-regulation of prostaglandin D2 receptors by agonist binding to beta-adrenoceptors in rabbit platelets. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004152 |
| Eling TE et al. | Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. | 1986 | J. Biol. Chem. | pmid:3007487 |
| Kuno S et al. | Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3010301 |
| Hattori Y and Levi R | Effect of PGD2 on cardiac contractility: a negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3012066 |
| Tsao CJ et al. | In-vitro effects of antineoplastic prostaglandins on human leukemic cell growth and normal myelopoiesis. | 1986 | Leuk. Res. | pmid:3012210 |
| Halenda SP et al. | Effects of thrombin, phorbol myristate acetate and prostaglandin D2 on 40-41 kDa protein that is ADP ribosylated by pertussis toxin in platelets. | 1986 | FEBS Lett. | pmid:3015684 |
| Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
| Bhattacharya SK | The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. | 1986 | Psychopharmacology (Berl.) | pmid:3016786 |
| Hamid-Bloomfield S and Whittle BJ | Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets. | 1986 | Br. J. Pharmacol. | pmid:3017497 |
| Ruzicka T et al. | Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. | 1986 | J. Invest. Dermatol. | pmid:3018086 |
| Shalit M et al. | New role for heparan sulfate: regulator of leukotriene generation in mouse E-mast cells. | 1986 | Life Sci. | pmid:3018403 |
| Zavoico GB et al. | Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. | 1986 | J. Biol. Chem. | pmid:3020026 |