| MeSH term | MeSH ID | Detail |
|---|---|---|
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Dyskinesia, Drug-Induced | D004409 | 15 associated lipids |
| HIV Seropositivity | D006679 | 15 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Adenomatous Polyposis Coli | D011125 | 16 associated lipids |
| Blister | D001768 | 16 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mutalithas K et al. | CRTH2 expression on T cells in asthma. | 2010 | Clin. Exp. Immunol. | pmid:20491797 |
| Koharudin LM et al. | Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20231490 |
| Norman P | DP(2) receptor antagonists in development. | 2010 | Expert Opin Investig Drugs | pmid:20615077 |
| Pedersen PJ et al. | Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20591667 |
| Bai YJ et al. | A LC-MS-based method for quantification of biomarkers from serum of allergic rats. | 2010 | Molecules | pmid:20657485 |
| Reddy RC and Standiford TJ | Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:20634499 |
| Ahmad AS et al. | Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice. | 2010 | Age (Dordr) | pmid:20640551 |
| Zhang HX et al. | Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). | 2010 | Exp. Neurol. | pmid:20083106 |
| Katura T et al. | 15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state. | 2010 | Mol. Pharmacol. | pmid:20086036 |
| Buga GM et al. | L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19965777 |
| Roy SJ et al. | Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif. | 2010 | Eur. J. Pharmacol. | pmid:20035740 |
| Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
| Byrns MC et al. | Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20036328 |
| Templeton DJ et al. | Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity. | 2010 | PLoS ONE | pmid:21085594 |
| Moraes LA et al. | Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. | 2010 | J. Thromb. Haemost. | pmid:20040043 |
| Subra C et al. | Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. | 2010 | J. Lipid Res. | pmid:20424270 |
| Hatanaka M et al. | 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. | 2010 | J. Pharmacol. Sci. | pmid:20424389 |
| Maggiora M et al. | Involvement of PPARα and PPARγ in apoptosis and proliferation of human hepatocarcinoma HepG2 cells. | 2010 | Cell Biochem. Funct. | pmid:20862655 |
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| Lee JJ et al. | The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. | 2010 | Arch. Pharm. Res. | pmid:20361303 |
| Pérez-Novo CA et al. | CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. | 2010 | Allergy | pmid:19839971 |
| Mo C et al. | PPARgamma regulates LIF-induced growth and self-renewal of mouse ES cells through Tyk2-Stat3 pathway. | 2010 | Cell. Signal. | pmid:19922793 |
| Kanda N et al. | Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes. | 2010 | Biochem. Pharmacol. | pmid:19925780 |
| Biburger M et al. | Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity. | 2010 | J. Leukoc. Biol. | pmid:19797297 |
| Guo N et al. | Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. | 2010 | J. Biol. Chem. | pmid:20308056 |
| Poncin S et al. | N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. | 2010 | Am. J. Pathol. | pmid:20489149 |
| Galvão Nascimento N et al. | Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. | 2010 Feb-Mar | Toxicon | pmid:19703484 |
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| Erttmann SF et al. | PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2. | 2011 | Free Radic. Biol. Med. | pmid:21651978 |
| Chiba T et al. | The opposing role of two prostaglandin D2 receptors, DP and CRTH2, in human eosinophil migration. | 2011 | Ann. Allergy Asthma Immunol. | pmid:21624751 |
| Liu TY et al. | [Advances in the study of histaminergic systems and sleep-wake regulation]. | 2011 | Yao Xue Xue Bao | pmid:21626776 |
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| Ugajin T et al. | FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. | 2011 | Am. J. Pathol. | pmid:21712025 |
| Tobiasova Z et al. | Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. | 2011 | Circulation | pmid:21690493 |
| Ebersberger A et al. | Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. | 2011 | Pain | pmid:21345590 |
| Flachs P et al. | Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. | 2011 | Diabetologia | pmid:21779874 |
| Lalier L et al. | Prostaglandins antagonistically control Bax activation during apoptosis. | 2011 | Cell Death Differ. | pmid:20966963 |
| Sharma I et al. | In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells. | 2011 | Fertil. Steril. | pmid:20970133 |
| Mesquita-Santos FP et al. | Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. | 2011 | Br. J. Pharmacol. | pmid:20973774 |
| Wienecke T et al. | Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin Dâ‚‚ (PGDâ‚‚). | 2011 | Cephalalgia | pmid:20974593 |
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| Kuehn HS et al. | Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. | 2011 | J. Biol. Chem. | pmid:20980255 |
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| Lu Y et al. | Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. | 2011 | Biochem. Pharmacol. | pmid:21907188 |
| Burke SJ and Collier JJ | The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells. | 2011 | Cell. Immunol. | pmid:21885043 |
| Crosignani S et al. | Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. | 2011 | J. Med. Chem. | pmid:21916510 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
| Urade Y and Hayaishi O | Prostaglandin D2 and sleep/wake regulation. | 2011 | Sleep Med Rev | pmid:22024172 |
| Wan CJ et al. | [PPARgamma agonists against respiratory syncytial virus infection in vitro study]. | 2011 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:22734242 |