PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Leukemia D007938 74 associated lipids
Leukemia P388 D007941 43 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Megakaryoblastic, Acute D007947 7 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Diseases D008171 37 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Haack M et al. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. 2007 Sleep pmid:17910386
Abdelrahman M et al. The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. 2004 Shock pmid:15545828
Hickson-Bick DL et al. The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. 2006 Shock pmid:16680021
Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
Genovese T et al. Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. 2008 Shock pmid:18628687
Monroy MA et al. THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. 2007 Shock pmid:17510607
Zingarelli B et al. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt. 2007 Shock pmid:17589386
Guyton K et al. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. 2003 Shock pmid:12813370
Kaplan J et al. Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. 2007 Shock pmid:17621259
Kaplan JM et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock. 2005 Shock pmid:15988322
Piraino G et al. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. 2006 Shock pmid:16878022
Hovsepian E et al. 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. 2010 Shock pmid:19997048
Yeh CH et al. Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. 2006 Shock pmid:16912651
Li LH and Ku BS [Regulation of SWS by hormones and cytokines]. 2000 Sheng Li Ke Xue Jin Zhan pmid:12532764
Moniot B et al. Male specific expression of lipocalin-type prostaglandin D synthase (cPTGDS) during chicken gonadal differentiation: relationship with cSOX9. 2008 Sex Dev pmid:18577876
Watanabe K [PGF synthetase]. 1986 Seikagaku pmid:3084680
Shibata T and Uchida K [Current opinions on prostaglandin J2]. 2005 Seikagaku pmid:16241007
Inoué S [Sleep substances: their roles and evolution]. 1983 Seikagaku pmid:6355327
Satoh T [Cysteine-mediated signaling pathway by a novel electrophilic compound, NEPP11]. 2007 Seikagaku pmid:17319510
Watanabe K [Structure and function of prostaglandin F synthetase]. 1989 Seikagaku pmid:2693551
Matsuoka T et al. Prostaglandin D2 as a mediator of allergic asthma. 2000 Science pmid:10720327
Kalgutkar AS et al. Aspirin-like molecules that covalently inactivate cyclooxygenase-2. 1998 Science pmid:9596581
Dutta-Roy AK et al. Prostacyclin stimulation of the activation of blood coagulation factor X by platelets. 1986 Science pmid:3001935
Garza LA et al. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. 2012 Sci Transl Med pmid:22440736
Okuyama S and Mishina H Principia of cancer therapy. X. Prostaglandin D2 triggers redifferentiation of the bestatin-treated breast cancer cells in vitro. 1985 Sci Rep Res Inst Tohoku Univ Med pmid:3870142
Okuyama S and Mishina H Principia of cancer therapy. XI. Prostaglandin D2 induces redifferentiation of M1 leukemia cells in vitro irrespective of bestatin. 1985 Sci Rep Res Inst Tohoku Univ Med pmid:3870143
Ma J et al. Effect of the PGD2-DP signaling pathway on primary cultured rat hippocampal neuron injury caused by aluminum overload. 2016 Sci Rep pmid:27089935
Shibata T et al. Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. 2016 Sci Rep pmid:26879669
Yoon YS et al. Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF. 2016 Sci Rep pmid:26875548
Guan PP et al. The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage. 2015 Sci Rep pmid:25992485
Fredman G et al. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. 2012 Sci Rep pmid:22957142
Martínez-Gras I et al. The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. 2011 Schizophr. Res. pmid:21334179
Ward PE et al. Niacin skin flush in schizophrenia: a preliminary report. 1998 Schizophr. Res. pmid:9516668
Martinez-Cengotitabengoa M et al. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. 2016 Schizophr Bull pmid:26130821
García-Bueno B et al. Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. 2014 Schizophr Bull pmid:23486748
Csala M et al. Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver. 1998 Scand. J. Immunol. pmid:9743211
Goto H et al. The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. 1989 Scand. J. Gastroenterol. Suppl. pmid:2595317
Aschenbach JR et al. Functional characteristics of the porcine colonic epithelium following transportation stress and Salmonella infection. 2007 Scand. J. Gastroenterol. pmid:17505993
Salińska E et al. Role of Ca2+ release from ryanodine stores in generation of NMDA-induced Ca2+ signal in rabbit hippocampus. 1999 Ross Fiziol Zh Im I M Sechenova pmid:10389178
Gaetani P et al. [Prostaglandin D2 in subarachnoid hemorrhage. Biological and diagnostic implications]. 1983 Jul-Aug Riv Patol Nerv Ment pmid:6598516
Hayaishi O [The brain and prostaglandins]. 1983 Rinsho Shinkeigaku pmid:6587956
Ji JD et al. Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. 2005 Rheumatology (Oxford) pmid:15840591
Jakob M et al. Chondrogenesis of expanded adult human articular chondrocytes is enhanced by specific prostaglandins. 2004 Rheumatology (Oxford) pmid:15113997
Nicolaidis S et al. [Variations of hypothalamic and cortical prostaglandins and monoamines reveal transitions in arousal states: microdialysis study in the rat]. 2001 Rev. Neurol. (Paris) pmid:11924034
Dorta-Contreras AJ et al. [Beta trace protein in the cerebrospinal fluid and serum in meningoencephalitis]. 1998 Rev Neurol pmid:9585948
Carsin A et al. [Physiopathology of aspirin intolerant asthma]. 2012 Rev Mal Respir pmid:22405107
Mendoza Magaña MJ et al. [Anaphylaxis and anaphylactic shock]. 2007 Mar-Apr Rev Alerg Mex pmid:17542244
Qiu Z et al. Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux. 2011 Respirology pmid:21342332
Miadonna A et al. Mediators and allergic inflammation of human airways. 1988 Respiration pmid:2466314
Peters SP et al. The pharmacologic control of mediator release from human basophils and mast cells. 1986 Respiration pmid:3494282
Honma S et al. Effects of naturally-occurring acid fog on inflammatory mediators in airway and pulmonary functions in asthmatic patients. 2000 Respir Med pmid:11059945
Rossitto M et al. Multiple roles of the prostaglandin D2 signaling pathway in reproduction. 2015 Reproduction pmid:25269616
Jawerbaum A et al. Peroxynitrites and impaired modulation of nitric oxide concentrations in embryos from diabetic rats during early organogenesis. 2005 Reproduction pmid:16264098
Tinfo N and Komar C Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat. 2007 Reproduction pmid:17244745
Jawerbaum A et al. Modulation of nitric oxide concentration and lipid metabolism by 15-deoxy Delta12,14prostaglandin J2 in embryos from control and diabetic rats during early organogenesis. 2002 Reproduction pmid:12417000
Ulbrich SE et al. Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. 2009 Reproduction pmid:19470711
Capobianco E et al. 15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism. 2005 Reprod. Fertil. Dev. pmid:15899154
Bogacka I et al. The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. 2013 Reprod Biol pmid:24287039
Higashihara H et al. Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. 2004 Redox Rep. pmid:15720834
Takagi T et al. A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. 2004 Redox Rep. pmid:15720836
Wall SB et al. Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. 2015 Redox Biol pmid:25677088
Elremaly W et al. Ascorbylperoxide from parenteral nutrition induces an increase of redox potential of glutathione and loss of alveoli in newborn guinea pig lungs. 2014 Redox Biol pmid:25009773
Blomgren H et al. Prostaglandin sensitivity of the PHA-response of blood lymphocytes following radiation therapy for breast cancer. 1986 Radiother Oncol pmid:3466235
Rubin DB et al. The influence of exogenous eicosanoids on the radiation response of cultured bovine aortic endothelial cells. 1991 Radiat. Res. pmid:1898781
Skogvall S et al. Effects of capsazepine on human small airway responsiveness unravel a novel class of bronchorelaxants. 2007 Pulm Pharmacol Ther pmid:16731017
Wang X et al. Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. 2009 Pulm Pharmacol Ther pmid:19489131
Bhattacharya SK The antinociceptive effect of intracerebroventricularly administered prostaglandin D2 in the rat. 1986 Psychopharmacology (Berl.) pmid:3016786
García-Bueno B et al. The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. 2005 Psychopharmacology (Berl.) pmid:15719215
Nishino S et al. Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture. 1998 Psychiatry Res pmid:9657418
Marcone S and Fitzgerald DJ Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. 2013 Proteomics pmid:23606334
Gazi L et al. Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. 2005 Prostaglandins Other Lipid Mediat. pmid:15789622
Keelan J et al. 15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells. 2001 Prostaglandins Other Lipid Mediat. pmid:11785780
Funovics P et al. Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. 2006 Prostaglandins Other Lipid Mediat. pmid:16647637
Józkowicz A et al. 15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. 2004 Prostaglandins Other Lipid Mediat. pmid:15560113
Chowdhury AA et al. 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. 2011 Prostaglandins Other Lipid Mediat. pmid:21699992
Wang JJ and Mak OT Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells. 2011 Prostaglandins Other Lipid Mediat. pmid:21396480
Maxey KM et al. The nature and composition of 15-deoxy-Delta(12,14)PGJ(2). 2000 Prostaglandins Other Lipid Mediat. pmid:10936412
Clay CE et al. 15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells. 2000 Prostaglandins Other Lipid Mediat. pmid:10936413
Mc Clay EF The effects of Delta(12)-PGJ(2) on malignant cells. 2000 Prostaglandins Other Lipid Mediat. pmid:10936416
Hossain MS et al. Development of enzyme-linked immunosorbent assay for Δ12-prostaglandin J2 and its application to the measurement of the endogenous product generated by cultured adipocytes during the maturation phase. 2011 Prostaglandins Other Lipid Mediat. pmid:21237281
Nabe T et al. Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. 2011 Prostaglandins Other Lipid Mediat. pmid:21601002
Chen C and Bazan NG Lipid signaling: sleep, synaptic plasticity, and neuroprotection. 2005 Prostaglandins Other Lipid Mediat. pmid:16099392
Ragolia L et al. Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. 2008 Prostaglandins Other Lipid Mediat. pmid:18619553
O'Sullivan S et al. Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. 1999 Prostaglandins Other Lipid Mediat. pmid:10410385
Mazid MA et al. Development of enzyme-linked immunosorbent assay for prostaglandin D2 using the stable isosteric analogue as a hapten mimic and its application. 2007 Prostaglandins Other Lipid Mediat. pmid:17481559
Imaizumi T et al. 15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. 2003 Prostaglandins Other Lipid Mediat. pmid:14518569
Ye Y et al. Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. 2007 Prostaglandins Other Lipid Mediat. pmid:17643887
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301
Longo WE et al. Contribution of cyclooxygenase-1 and cyclooxygenase-2 to prostanoid formation by human enterocytes stimulated by calcium ionophore and inflammatory agents. 1998 Prostaglandins Other Lipid Mediat. pmid:9990676
Butterfield JH Survey of aspirin administration in systemic mastocytosis. 2009 Prostaglandins Other Lipid Mediat. pmid:19429499
Willermain F et al. 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. 2006 Prostaglandins Other Lipid Mediat. pmid:16939878
Lim HJ et al. PPARgamma activation induces CD36 expression and stimulates foam cell like changes in rVSMCs. 2006 Prostaglandins Other Lipid Mediat. pmid:16939881
Ohinata K et al. Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. 2009 Prostaglandins Other Lipid Mediat. pmid:19800413
Jozkowicz A et al. Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner. 2001 Prostaglandins Other Lipid Mediat. pmid:11577781
Cao J et al. Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. 2008 Prostaglandins Other Lipid Mediat. pmid:18403225
Idborg H et al. Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. 2013 Prostaglandins Other Lipid Mediat. pmid:23916744
Nishimura H et al. Acute effects of prostaglandin D2 to induce airflow obstruction and airway microvascular leakage in guinea pigs: role of thromboxane A2 receptors. 2001 Prostaglandins Other Lipid Mediat. pmid:11519790
Lagarde M et al. Refractoriness of diabetic platelets to inhibitory prostaglandins. 1981 Prostaglandins Med pmid:6273957
Fukushima M Biological activities and mechanisms of action of PGJ2 and related compounds: an update. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1438462
Ikai K et al. Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7630918