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Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. |
2009 |
Leukemia |
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Csanky E et al. |
Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. |
2009 |
Electrophoresis |
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Kase K et al. |
Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. |
2009 |
Int. J. Mol. Med. |
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The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. |
2009 |
Biochem. J. |
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Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2. |
2009 |
Int. Arch. Allergy Immunol. |
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The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. |
2009 |
Endocrinology |
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Tsuji T et al. |
Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. |
2009 |
Neurochem. Res. |
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Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids. |
2009 |
J. Mol. Biol. |
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Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. |
2009 |
Dig. Dis. Sci. |
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15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. |
2009 |
J. Thromb. Haemost. |
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15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. |
2009 |
FASEB J. |
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Inhibition of prostaglandin D synthase suppresses muscular necrosis. |
2009 |
Am. J. Pathol. |
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Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. |
2009 |
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Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). |
2009 |
Int. Immunol. |
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Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. |
2009 |
World J. Gastroenterol. |
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Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries. |
2009 |
Clin. Exp. Allergy |
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A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. |
2009 |
Int. Immunol. |
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Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. |
2009 |
Int. Immunol. |
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Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. |
2009 |
Endocrinology |
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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. |
2009 |
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R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. |
2009 |
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Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. |
2009 |
Liver Int. |
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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. |
2009 |
Mol. Cell. Biol. |
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Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. |
2009 |
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CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. |
2009 |
Inflammation |
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15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. |
2009 |
Carcinogenesis |
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Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. |
2009 |
Circ. Res. |
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PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. |
2009 |
Acta Pharmacol. Sin. |
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Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. |
2009 |
Reproduction |
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A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. |
2009 |
Clin. Exp. Allergy |
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Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. |
2009 |
Pulm Pharmacol Ther |
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Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. |
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Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. |
2009 |
Clin Nutr |
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15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. |
2009 |
Cell. Mol. Life Sci. |
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2009 |
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2009 |
Cardiovasc. Res. |
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2009 |
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2009 |
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15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). |
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Lipid peroxidation: physiological levels and dual biological effects. |
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Free Radic. Biol. Med. |
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15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. |
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15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. |
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Biochem. Pharmacol. |
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GIF-0173 protects against cerebral infarction through DP1 receptor activation. |
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Exp. Neurol. |
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Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. |
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J. Neuropathol. Exp. Neurol. |
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In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. |
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CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. |
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Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands. |
2009 |
Exp. Dermatol. |
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Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. |
2009 |
PLoS ONE |
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Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. |
2009 |
Endocrinology |
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Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. |
2009 |
J Clin Pharmacol |
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15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. |
2009 |
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AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. |
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Cancer Res. |
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MMP/ TIMP balance is modulated in vitro by 15dPGJ(2) in fetuses and placentas from diabetic rats. |
2009 |
Eur. J. Clin. Invest. |
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Genetic mechanisms underlying male sex determination in mammals. |
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Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. |
2008 May-Jun |
Pharmacol Rep |
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A quercetin containing supplement reduces niacin-induced flush in humans. |
2008 Jul-Sep |
Int J Immunopathol Pharmacol |
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Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. |
2008 Jul-Aug |
Mol. Med. |
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Antagonists of the prostaglandin D2 receptor CRTH2. |
2008 Jul-Aug |
Drug News Perspect. |
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Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. |
2008 Jul-Aug |
Channels (Austin) |
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Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. |
2008 Jul-Aug |
Prostaglandins Leukot. Essent. Fatty Acids |
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AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. |
2008 |
Mol. Cell. Endocrinol. |
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Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. |
2008 |
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Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. |
2008 |
Cancer Lett. |
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Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. |
2008 |
Blood |
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Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). |
2008 |
J. Pharmacol. Exp. Ther. |
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Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. |
2008 |
Biochem. Biophys. Res. Commun. |
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Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. |
2008 |
Shock |
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Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. |
2008 |
J. Leukoc. Biol. |
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Regulation of TLR2 expression by prostaglandins in brain glia. |
2008 |
J. Immunol. |
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An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. |
2008 |
J. Immunol. |
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Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. |
2008 |
Mol. Cancer Ther. |
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Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. |
2008 |
Prostaglandins Other Lipid Mediat. |
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Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases. |
2008 |
Toxicon |
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Capobianco E et al. |
Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. |
2008 |
Mol. Hum. Reprod. |
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Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza. |
2008 |
Arch. Pharm. Res. |
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Dubourdeau M et al. |
Opposite roles of STAT and PPARgamma in the induction of p21WAF1 expression by IL-13 in human peripheral blood monocytes. |
2008 |
Eur. Cytokine Netw. |
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Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation. |
2008 |
Neuroreport |
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Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. |
2008 |
Gene |
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GarcÃa-Bueno B et al. |
Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. |
2008 |
Endocrinology |
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On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. |
2008 |
Cell. Mol. Life Sci. |
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Hounoki H et al. |
Activation of peroxisome proliferator-activated receptor gamma inhibits TNF-alpha-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression. |
2008 |
Bone |
pmid:18242157
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Zhao H et al. |
Rubimetide (Met-Arg-Trp) derived from Rubisco exhibits anxiolytic-like activity via the DP1 receptor in male ddY mice. |
2008 |
Peptides |
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Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice. |
2008 |
FEBS Lett. |
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Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus. |
2008 |
J. Mol. Biol. |
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Kim EH et al. |
15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. |
2008 |
Carcinogenesis |
pmid:18192694
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Prenn C et al. |
CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine. |
2008 |
Pharmacology |
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Novel biphasic role for lymphocytes revealed during resolving inflammation. |
2008 |
Blood |
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Kuesap J et al. |
Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells. |
2008 |
Biochem. Biophys. Res. Commun. |
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BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. |
2008 |
Oncol. Rep. |
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Up-regulation of heme oxygenase-1 expression through the Rac1/NADPH oxidase/ROS/p38 signaling cascade mediates the anti-inflammatory effect of 15-deoxy-delta 12,14-prostaglandin J2 in murine macrophages. |
2008 |
FEBS Lett. |
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Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs. |
2008 |
J. Cell. Mol. Med. |
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[Prostaglandin D2: new roles in the embryonic and pathological gonad]. |
2008 |
Med Sci (Paris) |
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Salicylamide-induced anaphylaxis: increased urinary leukotriene E4 and prostaglandin D2 metabolite. |
2008 |
Allergy |
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Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts. |
2008 |
Br. J. Pharmacol. |
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Khan AH et al. |
Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility. |
2008 |
Eur. J. Pharmacol. |
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Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. |
2008 |
Atherosclerosis |
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CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. |
2008 |
J. Immunol. |
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Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. |
2008 |
Vet. Immunol. Immunopathol. |
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