PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe K et al. | Biosynthesis of prostaglandin F2 alpha from prostaglandins H2 and D2 by an apparently homogeneous enzyme. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936081 |
| Liston TE et al. | Prostaglandin D2 is metabolized in humans to 9 alpha,11 beta-prostaglandin F2, a novel biologically active prostaglandin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936123 |
| Kimura H et al. | Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro. | 1985 | Brain Res. | pmid:2859088 |
| Toda N et al. | Neuroeffector actions of prostaglandins on isolated arteries. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936153 |
| Ueno R et al. | Prostaglandin D2: a cerebral sleep-regulating substance in rats. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936173 |
| Orchard MA et al. | Thromboxane synthase inhibition causes re-direction of prostaglandin endoperoxides to prostaglandin D2 during collagen stimulated aggregation of human platelet rich plasma. | 1985 | Thromb. Res. | pmid:3936223 |
| Fitscha P et al. | Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease. | 1985 | Am. J. Hematol. | pmid:3885723 |
| Wong P et al. | Diminished sensitivity of platelet aggregation to prostaglandin D2 in patients with myeloproliferative disorders and in patients with acute leukemia. | 1985 | Nippon Ketsueki Gakkai Zasshi | pmid:3890456 |
| Cutler LS et al. | Cytochemical localization of adenylate cyclase in the dense tubule system of human blood platelets stimulated by forskolin, prostacyclin and prostaglandin D2. | 1985 | Biochim. Biophys. Acta | pmid:3890960 |
| Siegl PK and Wenger HC | Cardiovascular responses to an isosterically modified prostaglandin analog in the anesthetized dog. | 1985 | Eur. J. Pharmacol. | pmid:3899681 |
| Regulatory control and standardization of allergenic extracts. Clinical studies with "standardized" extracts. | 1985 | Arb Paul Ehrlich Inst Georg Speyer Haus Ferdinand Blum Inst Frankf A M | pmid:3901924 | |
| Campbell WB and Gomez-Sanchez CE | Absence of prostacyclin involvement in angiotensin-induced aldosterone secretion in rat adrenal cells. | 1985 | Endocrinology | pmid:3924581 |
| McGuire JC et al. | Production of prostaglandin D2 by murine macrophage cell lines. | 1985 | Prostaglandins | pmid:3937182 |
| Lewis RA et al. | Pharmacologic regulation of mediator generation and release from the murine bone marrow derived mast cell. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409010 |
| Norman PS et al. | Mediator release after allergic and physical nasal challenges. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:2409027 |
| Schleimer RP et al. | Role of human basophils and mast cells in the pathogenesis of allergic diseases. | 1985 | J. Allergy Clin. Immunol. | pmid:2410478 |
| Majewska MD and Chuang DM | Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2857784 |
| Lad PM et al. | Receptor-specific threshold effects of cyclic AMP are involved in the regulation of enzyme release and superoxide production from human neutrophils. | 1985 | Biochim. Biophys. Acta | pmid:2411298 |
| Finney MJ et al. | Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. | 1985 | Br. J. Pharmacol. | pmid:2411319 |
| Fowler JC et al. | Prostaglandins block a Ca2+-dependent slow spike afterhyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. | 1985 | Brain Res. | pmid:2412652 |
| Levi-Schaffer F et al. | Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. | 1985 | J. Immunol. | pmid:2413121 |
| Forman MB et al. | Increased adventitial mast cells in a patient with coronary spasm. | 1985 | N. Engl. J. Med. | pmid:2413358 |
| Togias AG et al. | Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement. | 1985 | J. Clin. Invest. | pmid:2414318 |
| Schulman ES and Anderson CL | Lung hypersensitivity responses: dissociation of human lung mast cell leukotriene C4 (LTC4) from histamine release. | 1985 | Prog. Clin. Biol. Res. | pmid:2415994 |
| Creticos PS et al. | Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. | 1985 | J. Clin. Invest. | pmid:2416777 |
| Holgate ST et al. | The release and role of inflammatory mediators in asthma. | 1985 | Clin Immunol Rev | pmid:2417772 |
| Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
| Lewis RA and Robin JL | Arachidonic acid derivatives as mediators of asthma. | 1985 | J. Allergy Clin. Immunol. | pmid:3926852 |
| Westcott JY and Murphy RC | Effect of alcohols on arachidonic acid metabolism in murine mastocytoma cells and human polymorphonuclear leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:2982416 |
| Bhattacharya SK et al. | Prostaglandin D2 mediated specific increase in rat brain serotonin. | 1985 | Proc. West. Pharmacol. Soc. | pmid:3865228 |
| Walenga RW et al. | Re-examination of the assay for plasma prostanoids by solid-phase extraction, and radioimmunoassay. | 1985 | Prostaglandins Leukot Med | pmid:3865240 |
| Liston TE and Roberts LJ | Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3862115 |
| Tanaka H et al. | The effects of PGD2 and 9-deoxy-delta 9-PGD2 on colony formation of murine osteosarcoma cells. | 1985 | Prostaglandins | pmid:3863195 |
| Rocklin RE et al. | Decreased sensitivity of atopic mononuclear cells to prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). | 1985 | J. Immunol. | pmid:3160784 |
| Liston TE and Roberts LJ | Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. | 1985 | J. Biol. Chem. | pmid:3863815 |
| Knepel W et al. | Inhibition by prostaglandin E2 of the release of vasopressin and beta-endorphin from rat pituitary neurointermediate lobe or medial basal hypothalamus in vitro. | 1985 | J. Endocrinol. | pmid:3160802 |
| Roberts LJ and Sweetman BJ | Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. | 1985 | Prostaglandins | pmid:3864190 |
| Banks RO and Jacobson ED | Renal vasodilation with ureteral occlusion and prostaglandins: attenuation by histamine H1 antagonists. | 1985 | Am. J. Physiol. | pmid:2866716 |
| Weinreb RN et al. | Prostanoids in rabbit aqueous humor: effect of laser photocoagulation of the iris. | 1985 | Invest. Ophthalmol. Vis. Sci. | pmid:3860488 |
| Nielsen JA and Sparber SB | Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats. | 1985 | Pharmacol. Biochem. Behav. | pmid:3860881 |
| Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
| Costall B et al. | Modification of dyskinesias following the intrastriatal injection of prostaglandins in the rodent. | 1985 | Br. J. Pharmacol. | pmid:3862460 |
| Watanabe Y et al. | Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain. | 1985 | Brain Res. | pmid:2994820 |
| Pugliese G et al. | Hepatic transformation of prostaglandin D2 to a new prostanoid, 9 alpha,11 beta-prostaglandin F2, that inhibits platelet aggregation and constricts blood vessels. | 1985 | J. Biol. Chem. | pmid:3863819 |
| Whittle BJ et al. | Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:2871707 |
| Ueno R et al. | Changes of enzymes involved in prostaglandin metabolism and prostaglandin binding proteins in rat brain during development and aging. | 1985 | J. Neurochem. | pmid:3925085 |
| Hollingsworth EB and Patrick GA | Involvement of the serotonergic system in the prolongation of pentobarbital sleeping time produced by prostaglandin D2. | 1985 | Pharmacol. Biochem. Behav. | pmid:2859604 |
| Nolan PN et al. | Participation of prostanoids in chemical activation of the pericardial pressor reflex in dogs. | 1985 Jan-Feb | Clin. Exp. Pharmacol. Physiol. | pmid:3924453 |
| Korbut R and Gryglewski RJ | Anti-aggregatory prostanoids. Part I. | 1985 Sep-Dec | Acta Physiol Pol | pmid:3915631 |
| Holgate ST | The role of mast cells in the pathogenesis of asthma. | 1985 Sep-Oct | Bull Eur Physiopathol Respir | pmid:2415192 |