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The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. |
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Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. |
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Peroxisome proliferators compete and ameliorate Hcy-mediated endocardial endothelial cell activation. |
2002 |
Am. J. Physiol., Cell Physiol. |
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Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2). |
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Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma. |
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PPARgamma and vascular inflammation: adding another piece to the puzzle. |
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Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. |
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Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. |
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15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. |
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Anticancer Drugs |
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Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma. |
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Cytokine |
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Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. |
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Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha. |
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Biochim. Biophys. Acta |
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Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. |
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15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. |
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Kidney Int. |
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In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium. |
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Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. |
2002 |
Biochim. Biophys. Acta |
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Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. |
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J. Pharm. Pharmacol. |
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Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. |
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Clin. Immunol. |
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Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. |
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[The roles of the prostanoids played in the body]. |
2002 |
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Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. |
2002 |
Free Radic. Biol. Med. |
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Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid. |
2002 |
Immunology |
pmid:11972632
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Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages. |
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2000 |
J Renin Angiotensin Aldosterone Syst |
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Effect of PPARgamma ligands on the viability of gastric epithelial cells. |
2002 |
Aliment. Pharmacol. Ther. |
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The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation. |
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Mol. Pharmacol. |
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Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. |
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Genes Immun. |
pmid:11960303
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Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. |
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Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? |
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Cell. Signal. |
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Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. |
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Br. J. Cancer |
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Inhibition by prostaglandin E(2) of anaphylatoxin C5a- but not zymosan-induced prostanoid release from rat Kupffer cells. |
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Lab. Invest. |
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Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells. |
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Gut |
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Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR. |
2002 |
Am. J. Physiol., Cell Physiol. |
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Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. |
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J. Toxicol. Environ. Health Part A |
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Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids. |
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Biochem. Pharmacol. |
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[Prostaglandin D2: biosynthesis, biological properties and participation in bronchial asthma]. |
2001 |
Pol. Arch. Med. Wewn. |
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[Variations of hypothalamic and cortical prostaglandins and monoamines reveal transitions in arousal states: microdialysis study in the rat]. |
2001 |
Rev. Neurol. (Paris) |
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Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents. |
2002 |
Platelets |
pmid:11918832
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15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death. |
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Kidney Int. |
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15 deoxy delta12,14 PGJ2 induces procoagulant activity in cultured human endothelial cells. |
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Thromb. Haemost. |
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15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. |
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J. Immunol. |
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Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. |
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Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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Streptozotocin-pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. |
2002 |
Nitric Oxide |
pmid:11890746
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Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta. |
2002 |
Insect Biochem. Mol. Biol. |
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Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. |
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J. Exp. Med. |
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Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis. |
2002 |
Development |
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Roles of peroxisome proliferator-activated receptor gamma in cardiovascular disease. |
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J. Diabetes Complicat. |
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Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. |
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Osteoarthr. Cartil. |
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Prostaglandins as modulators of immunity. |
2002 |
Trends Immunol. |
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PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. |
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Circ. Res. |
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Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. |
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J. Immunol. |
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Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. |
2002 |
Pancreas |
pmid:11854617
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Harris SG and Phipps RP |
Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. |
2002 |
Immunology |
pmid:11849312
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Hayaishi O and Urade Y |
Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. |
2002 |
Neuroscientist |
pmid:11843094
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Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation. |
2002 |
Free Radic. Biol. Med. |
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Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner. |
2002 |
Mol. Hum. Reprod. |
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Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. |
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Cell. Signal. |
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Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. |
2002 |
Biol. Reprod. |
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Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. |
2002 |
J. Immunol. |
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15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. |
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J. Immunol. |
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Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. |
2002 |
J. Immunol. |
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Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. |
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15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. |
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15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells. |
2001 |
Prostaglandins Other Lipid Mediat. |
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Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. |
2002 |
Am. J. Respir. Crit. Care Med. |
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Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. |
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Atherosclerosis |
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Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. |
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Mol. Pharmacol. |
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Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. |
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J. Immunol. |
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Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. |
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Biol. Reprod. |
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Production of prostaglandins and leukotrienes by pathogenic fungi. |
2002 |
Infect. Immun. |
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A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. |
2001 |
Chem. Res. Toxicol. |
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PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. |
2002 |
Am. J. Physiol., Cell Physiol. |
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Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. |
2001 |
J. Allergy Clin. Immunol. |
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The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. |
2001 |
J. Cell. Sci. |
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