| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hughes-Fulford M and Fukushima M | Control of cell cycle by metabolites of prostaglandin D2 through a non-cAMP mediated mechanism. | 1993 | Life Sci Adv Exp Clin Endocrinol | pmid:11539936 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Charlesworth EN et al. | Cutaneous late-phase response in food-allergic children and adolescents with atopic dermatitis. | 1993 | Clin. Exp. Allergy | pmid:7687509 |
| al-Laith M and Pearce FL | On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells. | 1993 | Int. Arch. Allergy Immunol. | pmid:7689004 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
| Kitanaka J et al. | Phloretin as an antagonist of prostaglandin F2 alpha receptor in cultured rat astrocytes. | 1993 | J. Neurochem. | pmid:8093482 |
| Sawyer MM et al. | Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. | 1993 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:8281741 |
| Rangachari PK and Betti PA | Biological activity of metabolites of PGD2 on canine proximal colon. | 1993 | Am. J. Physiol. | pmid:8498516 |
| Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
| Woodward DF et al. | Further studies on ocular responses to DP receptor stimulation. | 1993 | Eur. J. Pharmacol. | pmid:8440310 |
| Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
| Koizumi T et al. | Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione. | 1993 | Biochem. Pharmacol. | pmid:8328983 |
| Furukawa F et al. | Relationship between heat shock protein induction and the binding of antibodies to the extractable nuclear antigens on cultured human keratinocytes. | 1993 | J. Invest. Dermatol. | pmid:8345220 |
| Harada T et al. | Arachidonic acid metabolism by isolated and cultured middle ear epithelial cells from the chinchilla. | 1993 | Eur Arch Otorhinolaryngol | pmid:8369117 |
| Takagi T et al. | Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats. | 1993 | Calcif. Tissue Int. | pmid:8369992 |
| Püschel GP et al. | Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. | 1993 | Hepatology | pmid:8244278 |
| Neuschäfer-Rube F et al. | Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. | 1993 | Eur. J. Biochem. | pmid:8425526 |
| Hata Y et al. | Primary colonic epithelial cell culture of the rabbit producing prostaglandins. | 1993 | Prostaglandins | pmid:8430223 |
| Jaffar ZH and Pearce FL | Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells. | 1993 | Agents Actions | pmid:7511869 |
| Spatz M et al. | Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505058 |
| Casolaro V et al. | Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7505332 |
| Hay DW et al. | Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea. | 1993 | Br. J. Pharmacol. | pmid:7507780 |
| Inase N et al. | Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8217194 |
| Itoh Y et al. | [Inhibitory effects of AA-2414, a thromboxane (Tx) A2 receptor antagonist, on U-46619-, prostaglandin (PG) D2- and 9 alpha, 11 beta PGF2-induced contractions of guinea pig tracheas and isolated human bronchi]. | 1993 | Arerugi | pmid:8279967 |
| Liu P et al. | [Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8257841 |
| Rajakulasingam K et al. | Interactive effect of inhaled bradykinin with histamine and PGD2 in bronchial asthma. | 1993 | J. Appl. Physiol. | pmid:8307852 |
| van der Linden PW et al. | Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation. | 1992 | J. Allergy Clin. Immunol. | pmid:1629497 |
| Thomas PS et al. | Tobacco smoke releases performed mediators from canine mast cells and modulates prostaglandin production. | 1992 | Am. J. Physiol. | pmid:1636731 |
| Sasaguri T et al. | Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression. | 1992 | Exp. Cell Res. | pmid:1572402 |
| Sinzinger H et al. | Isradipine improves platelet function in hypertensives. | 1992 | Eur. J. Clin. Pharmacol. | pmid:1531796 |
| Liu H et al. | Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide. | 1992 | J. Biol. Chem. | pmid:1328211 |
| González-Utor AL et al. | Cytochemical localization of K(+)-dependent p-nitrophenyl phosphatase and adenylate cyclase by using one-step method in human washed platelets. | 1992 | Histochemistry | pmid:1330994 |
| Amici C et al. | Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation. | 1992 | Antiviral Res. | pmid:1332600 |
| Seregi A et al. | Functionally diverse purinergic P2Y-receptors mediate prostanoid synthesis in cultured rat astrocytes: the role of ATP-induced phosphatidyl-inositol breakdown. | 1992 | Eicosanoids | pmid:1333251 |
| Knani J et al. | Indirect evidence of nasal inflammation assessed by titration of inflammatory mediators and enumeration of cells in nasal secretions of patients with chronic rhinitis. | 1992 | J. Allergy Clin. Immunol. | pmid:1334102 |
| Stellato C et al. | Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release. | 1992 | Anesthesiology | pmid:1280014 |
| de Paulis A et al. | Anti-inflammatory effect of FK-506 on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1281861 |
| Tomita Y et al. | Melanocyte-stimulating properties of arachidonic acid metabolites: possible role in postinflammatory pigmentation. | 1992 | Pigment Cell Res. | pmid:1292020 |
| Morii H and Watanabe Y | A possible role of carbohydrate moieties in prostaglandin D2 and prostaglandin E2 receptor proteins from the porcine temporal cortex. | 1992 | Arch. Biochem. Biophys. | pmid:1309289 |
| Wang JP et al. | Anti-inflammatory and analgesic effects of magnolol. | 1992 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:1336574 |
| Kuchinke W et al. | A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1339268 |
| Columbo M et al. | The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. | 1992 | J. Immunol. | pmid:1378071 |
| Goerg KJ et al. | Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2. | 1992 | Gastroenterology | pmid:1379954 |
| Baumgarten CR et al. | Bradykinin and other inflammatory mediators in BAL-fluid from patients with active pulmonary inflammation. | 1992 | Agents Actions Suppl. | pmid:1462881 |
| Ellis JL and Undem BJ | Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1323657 |
| Tamaoki J et al. | Prostaglandin D2 increases Cl secretion across canine tracheal epithelium through cyclo-oxygenase stimulation and cAMP production. | 1992 | Acta Physiol. Scand. | pmid:1323920 |
| Froldi M et al. | Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement. | 1992 | J. Neuroimmunol. | pmid:1315794 |
| Fukushima M | Biological activities and mechanisms of action of PGJ2 and related compounds: an update. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1438462 |