| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van der Linden PW et al. | Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation. | 1992 | J. Allergy Clin. Immunol. | pmid:1629497 |
| King KL et al. | Metabolism of arachidonic acid by isolated rabbit ciliary epithelium. | 1992 | Exp. Eye Res. | pmid:1426059 |
| Thomas PS et al. | Tobacco smoke releases performed mediators from canine mast cells and modulates prostaglandin production. | 1992 | Am. J. Physiol. | pmid:1636731 |
| Sasaguri T et al. | Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression. | 1992 | Exp. Cell Res. | pmid:1572402 |
| Sinzinger H et al. | Isradipine improves platelet function in hypertensives. | 1992 | Eur. J. Clin. Pharmacol. | pmid:1531796 |
| Tsukagoshi H and Kurosawa M | [Bronchial hyperresponsiveness to histamine induced by intravenous administration of prostaglandin D2 (PGD2) in guinea pigs]. | 1992 | Nippon Yakurigaku Zasshi | pmid:1559641 |
| Magnussen H et al. | Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction. | 1992 | J. Allergy Clin. Immunol. | pmid:1535083 |
| Campbell AM et al. | In vitro activation of bronchoalveolar lavage cells by house dust mite allergens. | 1992 | Ann Allergy | pmid:1371209 |
| Gaetani P et al. | Ex vivo release of eicosanoids after aneurysmal subarachnoid hemorrhage: a preliminary experience in humans. | 1992 | Acta Neurol. Scand. | pmid:1414230 |
| Mitsuoka S et al. | Inhibitory effect of prostaglandin delta 12-PGJ2 on cell proliferation and alpha-fetoprotein expression in HuH-7 human hepatoma cells. | 1992 | Prostaglandins | pmid:1371888 |
| Yen A et al. | Protoporphyrin and long-wave ultraviolet light modulate metabolic events in rat peritoneal mast cells. | 1992 | J. Invest. Dermatol. | pmid:1372341 |
| Stellato C et al. | Anti-inflammatory effect of cyclosporin A on human skin mast cells. | 1992 | J. Invest. Dermatol. | pmid:1373749 |
| Morrow JD et al. | Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. | 1992 | J. Invest. Dermatol. | pmid:1373750 |
| Okayama Y et al. | Inhibition profiles of sodium cromoglycate and nedocromil sodium on mediator release from mast cells of human skin, lung, tonsil, adenoid and intestine. | 1992 | Clin. Exp. Allergy | pmid:1375128 |
| Okayama Y and Church MK | Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. | 1992 | Int. Arch. Allergy Immunol. | pmid:1375203 |
| Smith JB et al. | Cyclic AMP does not inhibit collagen-induced platelet signal transduction. | 1992 | Biochem. J. | pmid:1375452 |
| Ikai K et al. | Induction of 72-kD heat shock protein and cytoskeleton damage by cytotoxic prostaglandin delta 12-PGJ2 in transformed human epidermal cells in culture. | 1992 | J. Invest. Dermatol. | pmid:1375619 |
| Lippton HL et al. | Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed. | 1992 | Am. J. Physiol. | pmid:1348400 |
| Crea AE et al. | Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma. | 1992 | Eur. Respir. J. | pmid:1348480 |
| Shin MH et al. | The effect of azelastine on the early allergic response. | 1992 | Clin. Exp. Allergy | pmid:1349259 |
| Mulkins MA et al. | Mycophenolic acid inhibits the degranulation of rat peritoneal mast cells. | 1992 | Cell. Immunol. | pmid:1349511 |
| Liu H et al. | Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide. | 1992 | J. Biol. Chem. | pmid:1328211 |
| González-Utor AL et al. | Cytochemical localization of K(+)-dependent p-nitrophenyl phosphatase and adenylate cyclase by using one-step method in human washed platelets. | 1992 | Histochemistry | pmid:1330994 |
| Raible DG et al. | Mast cell mediators prostaglandin-D2 and histamine activate human eosinophils. | 1992 | J. Immunol. | pmid:1588043 |
| Amici C et al. | Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation. | 1992 | Antiviral Res. | pmid:1332600 |
| Seregi A et al. | Functionally diverse purinergic P2Y-receptors mediate prostanoid synthesis in cultured rat astrocytes: the role of ATP-induced phosphatidyl-inositol breakdown. | 1992 | Eicosanoids | pmid:1333251 |
| Knani J et al. | Indirect evidence of nasal inflammation assessed by titration of inflammatory mediators and enumeration of cells in nasal secretions of patients with chronic rhinitis. | 1992 | J. Allergy Clin. Immunol. | pmid:1334102 |
| Charlesworth EN et al. | Effect of H1 receptor blockade on the early and late response to cutaneous allergen challenge. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1382132 |
| Murakami M et al. | Release of 14-kDa group-II phospholipase A2 from activated mast cells and its possible involvement in the regulation of the degranulation process. | 1992 | Eur. J. Biochem. | pmid:1382985 |
| Johnston SL et al. | The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations. | 1992 | Br J Clin Pharmacol | pmid:1467134 |
| Lin CH et al. | HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets. | 1992 | Thromb. Res. | pmid:1412184 |
| Koizumi T et al. | Inhibitory effect of an intracellular glutathione on delta 12-prostaglandin J2-induced protein syntheses in porcine aortic endothelial cells. | 1992 | Biochem. Pharmacol. | pmid:1417983 |
| Norwitz ER et al. | Prostaglandin D2 production by term human decidua: cellular origins defined using flow cytometry. | 1992 | Obstet Gynecol | pmid:1495703 |
| Sasaguri T et al. | Anti-proliferative effect of prostaglandins A and J on cultured vascular smooth muscle cells. | 1992 | Jpn. J. Pharmacol. | pmid:1507558 |
| Hoshi A et al. | [Experimental study on the role of prostaglandin D2 in the pathogenesis of bronchial asthma]. | 1992 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:1507684 |
| Bacic F et al. | Prostaglandin D2 in cultured capillary and microvascular endothelium of human brain. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508957 |
| Thomas PS et al. | Prostaglandin D2 production and identification of prostaglandin H synthase within canine mast cell granule. | 1992 | Am. J. Physiol. | pmid:1514641 |
| Kaiser L et al. | Dirofilaria immitis: do filarial cyclooxygenase products depress endothelium-dependent relaxation in the in vitro rat aorta? | 1992 | Exp. Parasitol. | pmid:1516664 |
| Braun M and Schrör K | Prostaglandin D2 relaxes bovine coronary arteries by endothelium-dependent nitric oxide-mediated cGMP formation. | 1992 | Circ. Res. | pmid:1385004 |
| Goto H et al. | Age-associated decreases in prostaglandin contents in human gastric mucosa. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1510674 |
| Emery BE et al. | The effect of IL-4 on human nasal mucosal responses. | 1992 | J. Allergy Clin. Immunol. | pmid:1430703 |
| Barrett KE | Effect of histamine and other mast cell mediators on T84 epithelial cells. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456653 |
| Diener M et al. | Characterization of the antisecretory action of prostaglandin D2 in the rat colon. | 1992 | Acta Physiol. Scand. | pmid:1502910 |
| Virgolini I et al. | Characterization of prostaglandin (PG)-binding sites expressed on human basophils. Evidence for a prostaglandin E1, I2, and a D2 receptor. | 1992 | J. Biol. Chem. | pmid:1377673 |
| Watanabe-Kohno S et al. | MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712. | 1992 | Jpn. J. Pharmacol. | pmid:1460800 |
| Baumgarten CR et al. | Bradykinin and other inflammatory mediators in BAL-fluid from patients with active pulmonary inflammation. | 1992 | Agents Actions Suppl. | pmid:1462881 |
| Ellis JL and Undem BJ | Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1323657 |
| Tamaoki J et al. | Prostaglandin D2 increases Cl secretion across canine tracheal epithelium through cyclo-oxygenase stimulation and cAMP production. | 1992 | Acta Physiol. Scand. | pmid:1323920 |
| Froldi M et al. | Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement. | 1992 | J. Neuroimmunol. | pmid:1315794 |
| Eguchi N et al. | Permeability of brain structures and other peripheral tissues to prostaglandins D2, E2 and F2 alpha in rats. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1527717 |