PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Astrocytoma D001254 15 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Matsushima Y et al. Distinct roles of prostaglandin D2 receptors in chronic skin inflammation. 2011 Mol. Immunol. pmid:21943706
Papageorgiou E et al. Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. 2008 Jul-Aug Mol. Med. pmid:18475308
Ashby B Novel mechanism of heterologous desensitization of adenylate cyclase: prostaglandins bind with different affinities to both stimulatory and inhibitory receptors on platelets. 1990 Mol. Pharmacol. pmid:1695318
Sykes DA et al. Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy. 2016 Mol. Pharmacol. pmid:26916831
Tanaka Y et al. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. 2007 Mol. Pharmacol. pmid:17151289
Yagami T et al. Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis. 2002 Mol. Pharmacol. pmid:11752212
Hata AN et al. Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. 2005 Mol. Pharmacol. pmid:15563582
Katura T et al. 15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state. 2010 Mol. Pharmacol. pmid:20086036
Mathiesen JM et al. On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2. 2006 Mol. Pharmacol. pmid:16418339
Lee SJ et al. Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation. 2006 Mol. Pharmacol. pmid:16611854
Rockwell CE et al. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. 2006 Mol. Pharmacol. pmid:16611855
Zhao G et al. Pivotal role of reactive oxygen species in differential regulation of lipopolysaccharide-induced prostaglandins production in macrophages. 2013 Mol. Pharmacol. pmid:23071105
Raman P et al. 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. 2011 Mol. Pharmacol. pmid:21511917
Savinainen JR et al. Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL). 2014 Mol. Pharmacol. pmid:25140003
Miwa Y et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces G(1) arrest and differentiation marker expression in vascular smooth muscle cells. 2000 Mol. Pharmacol. pmid:10999955
Cuzzocrea S et al. The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation. 2002 Mol. Pharmacol. pmid:11961117
Chen ZY and Tseng CC 15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signal transduction pathway in HT-29 colon cancer cells. 2005 Mol. Pharmacol. pmid:16077033
Mix KS et al. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. 2004 Mol. Pharmacol. pmid:14742672
Ianaro A et al. Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. 2003 Mol. Pharmacol. pmid:12815164
Chung SW et al. Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor. 2003 Mol. Pharmacol. pmid:14573767
Fionda C et al. Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes. 2007 Mol. Pharmacol. pmid:17673570
Stillman BA et al. Importance of the extracellular domain for prostaglandin EP(2) receptor function. 1999 Mol. Pharmacol. pmid:10462542
Ciucci A et al. Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. 2006 Mol. Pharmacol. pmid:16908599
Sánchez-Gómez FJ et al. Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes. 2004 Mol. Pharmacol. pmid:15317873
Jung KM et al. Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. 2003 Mol. Pharmacol. pmid:12606768
Berry EB et al. Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. 2005 Mol. Pharmacol. pmid:15821150
Bai YJ et al. A LC-MS-based method for quantification of biomarkers from serum of allergic rats. 2010 Molecules pmid:20657485
Wojno ED et al. The prostaglandin Dâ‚‚ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung. 2015 Mucosal Immunol pmid:25850654
Satoh K et al. Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein. 2001 Mutat. Res. pmid:11600134
Poynard T et al. Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. 1982 N. Engl. J. Med. pmid:6953312
Laidlaw TM and Boyce JA Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. 2016 N. Engl. J. Med. pmid:26840139
Knapp HR Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor. 1990 N. Engl. J. Med. pmid:1701029
Forman MB et al. Increased adventitial mast cells in a patient with coronary spasm. 1985 N. Engl. J. Med. pmid:2413358
Goetzl EJ Asthma: new mediators and old problems. 1984 N. Engl. J. Med. pmid:6330554
Naclerio RM et al. Inflammatory mediators in late antigen-induced rhinitis. 1985 N. Engl. J. Med. pmid:2582257
Murray JJ et al. Release of prostaglandin D2 into human airways during acute antigen challenge. 1986 N. Engl. J. Med. pmid:3462506
Wingard CJ et al. Mast cells contribute to altered vascular reactivity and ischemia-reperfusion injury following cerium oxide nanoparticle instillation. 2011 Nanotoxicology pmid:21043986
Pettipher R et al. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. 2007 Nat Rev Drug Discov pmid:17396136
Taketomi Y et al. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. 2013 Nat. Immunol. pmid:23624557
Starkl P et al. PLA2G3 promotes mast cell maturation and function. 2013 Nat. Immunol. pmid:23685814
Gilroy DW et al. Inducible cyclooxygenase may have anti-inflammatory properties. 1999 Nat. Med. pmid:10371510
Wang C et al. A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. 2014 Nat. Methods pmid:24292485
Luster AD and Tager AM T-cell trafficking in asthma: lipid mediators grease the way. 2004 Nat. Rev. Immunol. pmid:15343370
Ricote M et al. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. 1998 Nature pmid:9422508
Jiang C et al. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. 1998 Nature pmid:9422509
Rossi A et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. 2000 Nature pmid:10638762
Wang JP et al. Anti-inflammatory and analgesic effects of magnolol. 1992 Naunyn Schmiedebergs Arch. Pharmacol. pmid:1336574
Molderings GJ et al. Modulation of noradrenaline release from the sympathetic nerves of human right atrial appendages by presynaptic EP3- and DP-receptors. 1998 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9826066
Featherstone RL et al. Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha. 1990 Naunyn Schmiedebergs Arch. Pharmacol. pmid:2142256
Hsu MF et al. Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils. 2004 Naunyn Schmiedebergs Arch. Pharmacol. pmid:15083266