PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Astrocytoma D001254 15 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Csanky E et al. Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. 2009 Electrophoresis pmid:19294692
Lee DR et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. 2009 Toxicology pmid:19167456
Quarello E and Trabbia A High-definition flow combined with spatiotemporal image correlation in the diagnosis of fetal coarctation of the aorta. 2009 Ultrasound Obstet Gynecol pmid:19194864
Ishii T et al. Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. 2009 Blood pmid:19196660
Passeron T et al. Upregulation of SOX9 inhibits the growth of human and mouse melanomas and restores their sensitivity to retinoic acid. 2009 J. Clin. Invest. pmid:19273910
Yuan ZB et al. Temporal expression of cyclooxygenase-2 in peritoneal macrophages of rats and effects of panax notoginseng saponins. 2009 Inflamm. Res. pmid:19184357
Whelan CJ Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5. 2009 Inflamm. Res. pmid:19184361
Liu J et al. Peroxisome proliferator-activated receptor-gamma ligands 15-deoxy-delta(12,14)-prostaglandin J2 and pioglitazone inhibit hydroxyl peroxide-induced TNF-alpha and lipopolysaccharide-induced CXC chemokine expression in neonatal rat cardiac myocytes. 2009 Shock pmid:19174742
Kolaczkowska E et al. Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. 2009 Immunology pmid:19175797
Bruck R et al. Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. 2009 Dig. Dis. Sci. pmid:18594976
Boehme SA et al. Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). 2009 Int. Immunol. pmid:19346259
Iinuma K et al. Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. 2009 J. Invest. Dermatol. pmid:19282842
Ferguson HE et al. Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19286977
Xue L et al. Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells. 2009 Clin. Exp. Immunol. pmid:19220324
Ono E et al. Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis. 2009 Clin. Exp. Allergy pmid:19128354
Shin SW et al. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. 2009 Clin. Cancer Res. pmid:19690198
Wendeburg L et al. Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. 2009 J Neuroinflammation pmid:19751497
Ferguson HE et al. Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. 2009 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:19734319
Kim DH et al. Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723057
Wang WM et al. PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. 2009 Acta Pharmacol. Sin. pmid:19098936
Waku T et al. Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. 2009 FEBS Lett. pmid:19101554
Selg E et al. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. 2009 Prostaglandins Other Lipid Mediat. pmid:19103301
Dong YW et al. Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor gamma involves angiogenesis inhibition. 2009 World J. Gastroenterol. pmid:19152448
Koinuma S et al. The resetting of the circadian rhythm by Prostaglandin J2 is distinctly phase-dependent. 2009 FEBS Lett. pmid:19111547
Baregamian N et al. PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis. 2009 Biochem. Biophys. Res. Commun. pmid:19114032
Mickleborough TD et al. Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. 2009 Clin Nutr pmid:19054597
Comabella M et al. Plasma levels of 15d-PGJ are not altered in multiple sclerosis. 2009 Eur. J. Neurol. pmid:19538219
Qin HD et al. Upregulation of peroxisome proliferator-activated receptor-gamma and NADPH oxidases are involved in restenosis after balloon injury. 2009 J. Cell. Physiol. pmid:19562688
Leduc M et al. Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. 2009 J. Pharmacol. Exp. Ther. pmid:19584306
Bai G et al. Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. 2009 Peptides pmid:19539681
Pierre SR et al. Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice. 2009 J Neuroinflammation pmid:19630993
Pena-dos-Santos DR et al. Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint. 2009 Neuroscience pmid:19647045
Asano S et al. Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19616422
Hironaka A et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. 2009 Biochem. Biophys. Res. Commun. pmid:19799872
Ohinata K et al. Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. 2009 Prostaglandins Other Lipid Mediat. pmid:19800413
Tagen M et al. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. 2009 J. Immunol. pmid:19846869
Moreira V et al. Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19155166
Kolaczkowska E et al. Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. 2009 Nov-Dec Arch. Immunol. Ther. Exp. (Warsz.) pmid:19885646
Blancou P and Anegon I Editorial: Heme oxygenase-1 and dendritic cells: what else? 2010 J. Leukoc. Biol. pmid:20123679
Nørregaard R et al. Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20147610
Dionne S et al. PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. 2010 Anticancer Res. pmid:20150631
Zhu F et al. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. 2010 Cell Death Differ. pmid:20150912
Orlichenko LS et al. Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20671197
Fujitani Y et al. Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo. 2010 FEBS J. pmid:20136655
Li H et al. Serum amyloid A activates peroxisome proliferator-activated receptor γ through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes. 2010 Biochemistry pmid:20853849
Pacienza N et al. 15-deoxy-Delta(12,14)-PGJ(2) induces cell cycle arrest and apoptosis of haematopoietic progenitors. 2010 Br. J. Haematol. pmid:19764987
Lee CM et al. Prostaglandin expression profile in hypoxic osteoblastic cells. 2010 J. Bone Miner. Metab. pmid:19471853
Lin TH et al. Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. 2010 J. Cell. Physiol. pmid:20020468
Hovsepian E et al. 15-deoxy-Delta12,14 prostaglandin GJ2 but not rosiglitazone regulates metalloproteinase 9, NOS-2, and cyclooxygenase 2 expression and functions by peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms in cardiac cells. 2010 Shock pmid:19997048
Théoleyre S et al. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. 2010 Biochem. Biophys. Res. Commun. pmid:19951697