| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barr RM et al. | The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin. | 1988 | Br J Clin Pharmacol | pmid:2835975 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Featherstone RL et al. | Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness. | 1988 | Eur. Respir. J. | pmid:3229483 |
| Petrini B et al. | Modulation of lymphocyte and monocyte responses in vitro by 9-deoxy-delta 9-prostaglandin D2 and 9-deoxy-delta 9-delta 12-prostaglandin D2. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3229858 |
| Beasley R et al. | Comparative vascular effects of histamine, prostaglandin (PG) D2 and its metabolite 9 alpha,11 beta-PGF2 in human skin. | 1988 | Clin. Allergy | pmid:3242978 |
| Ohishi K et al. | Increased level of salivary prostaglandins in patients with major depression. | 1988 | Biol. Psychiatry | pmid:3422573 |
| Casteleijn E et al. | Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. | 1988 | J. Biol. Chem. | pmid:3422638 |
| Kuiper J et al. | Identification of prostaglandin D2 as the major eicosanoid from liver endothelial and Kupffer cells. | 1988 | Biochim. Biophys. Acta | pmid:3126817 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Regal JF | Role of arachidonate metabolites in C5a-induced bronchoconstriction. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841450 |
| Kawata R et al. | Prostaglandin synthesis by the cochlea. | 1988 | Prostaglandins | pmid:3129756 |
| Heavey DJ et al. | Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. | 1988 | J. Immunol. | pmid:2450136 |
| Parsons WG and Roberts LJ | Transformation of prostaglandin D2 to isomeric prostaglandin F2 compounds by human eosinophils. A potential mast cell-eosinophil interaction. | 1988 | J. Immunol. | pmid:3139758 |
| Nakagomi T et al. | Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries. | 1988 | J. Neurosurg. | pmid:2895803 |
| Negishi M et al. | Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. | 1988 | J. Biol. Chem. | pmid:2896200 |
| Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
| Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
| Casteleijn E et al. | Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. | 1988 | Biochem. J. | pmid:3162673 |
| Ishioka C et al. | Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. | 1988 | Cancer Res. | pmid:3162825 |
| Soifer SJ et al. | Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. | 1988 | J. Pediatr. | pmid:3162978 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Sonoki H et al. | [Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2]. | 1988 | Nippon Yakurigaku Zasshi | pmid:3163668 |
| Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
| Moore PK et al. | Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro. | 1988 | Eur. J. Pharmacol. | pmid:3053211 |
| Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
| Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
| Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
| Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |
| Rao PS et al. | The effect of prostaglandin D2 on angiotensin converting enzyme. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2845437 |
| Lebel B et al. | Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. | 1988 | J. Allergy Clin. Immunol. | pmid:2461405 |
| Bousquet J et al. | Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. | 1988 | J. Allergy Clin. Immunol. | pmid:2461406 |
| Church MM et al. | The mediator and cellular basis of the allergic response. | 1988 | Allergy | pmid:2462372 |
| Takei M et al. | Role of cyclic AMP during histamine release. Histamine release is not directly related to increase in cyclic AMP levels in rat mast cells activated by concanavalin A, anti-IgE, antigen, prostaglandin D2 and isoproterenol. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:2463844 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
| Ohno K et al. | Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361448 |
| Yue TL and Mai K | [Effects of protein malnutrition on the metabolism of arachidonic acid in the rat stomach and spleen]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3142210 |
| Shohami E et al. | Experimental closed head injury in rats: prostaglandin production in a noninjured zone. | 1988 | Neurosurgery | pmid:3164097 |
| Dieter P et al. | Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. | 1988 | Eur. J. Biochem. | pmid:2846298 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
| Lahoua Z et al. | Serum-induced arachidonic acid release and prostaglandin biosynthesis are potentiated by oxygenated sterols in NRK 49F cells. | 1988 | Biochim. Biophys. Acta | pmid:3124881 |
| Morimoto A et al. | Multiple control of fever production in the central nervous system of rabbits. | 1988 | J. Physiol. (Lond.) | pmid:3261794 |
| Kleeberger SR et al. | The role of mediators in the response of the canine peripheral lung to 1 ppm ozone. | 1988 | Am. Rev. Respir. Dis. | pmid:2829670 |
| Yokotani K et al. | Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3422095 |
| Miwa N et al. | Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture. | 1988 | J. Neurochem. | pmid:2834513 |