| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Saito K et al. | Blood components contribute to rise in gerbil brain levels of leukotriene-like immunoreactivity after ischemia and reperfusion. | 1988 | Stroke | pmid:3274043 |
| Giles H and Leff P | The biology and pharmacology of PGD2. | 1988 | Prostaglandins | pmid:3283848 |
| Featherstone RL et al. | Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness. | 1988 | Eur. Respir. J. | pmid:3229483 |
| Casteleijn E et al. | Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. | 1988 | J. Biol. Chem. | pmid:3422638 |
| Yamamoto K et al. | Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3056405 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Broide DH et al. | Functional and biochemical characterization of rat bone marrow derived mast cells. | 1988 | J. Immunol. | pmid:2974057 |
| Regal JF | Role of arachidonate metabolites in C5a-induced bronchoconstriction. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841450 |
| Nakagomi T et al. | Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries. | 1988 | J. Neurosurg. | pmid:2895803 |
| Negishi M et al. | Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. | 1988 | J. Biol. Chem. | pmid:2896200 |
| Barr RM et al. | The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions. | 1988 | Br. J. Pharmacol. | pmid:2460180 |
| Yang CY et al. | Isolation and culture of two cell populations from chick calvaria by density gradient: prostaglandin synthesis by the cells in culture and coculture. | 1988 | Endocrinology | pmid:2844516 |
| Chock SP and Schmauder-Chock EA | Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3190706 |
| Undem BJ et al. | Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2459368 |
| Suzuki K et al. | Inhibition of human gingival carcinoma cell growth by prostaglandins. | 1988 | Gen. Pharmacol. | pmid:3162424 |
| Goh Y et al. | Prostaglandin D2 reduces intraocular pressure. | 1988 | Br J Ophthalmol | pmid:3164634 |
| Onoe H et al. | Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3163802 |
| Shohami E et al. | Experimental closed head injury in rats: prostaglandin production in a noninjured zone. | 1988 | Neurosurgery | pmid:3164097 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |
| Morimoto A et al. | Multiple control of fever production in the central nervous system of rabbits. | 1988 | J. Physiol. (Lond.) | pmid:3261794 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| Zijlstra FJ et al. | Formation of prostaglandins and leukotrienes by human lung tissue in vitro after activation by the calcium ionophore A23187. | 1987 | Eur. J. Clin. Invest. | pmid:2822430 |
| Narumiya S and Fukushima M | Active transport and cellular accumulation of cyclopentenone prostaglandins: a mechanism of prostaglandin-induced growth inhibition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960214 |
| Ono K et al. | Suppressive effects of various antitumor prostaglandin derivatives on the activity levels of DNA polymerases in human cultured tumor cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960215 |
| Beasley R et al. | Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. | 1987 | Am. Rev. Respir. Dis. | pmid:2960256 |
| Saito R et al. | The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. | 1987 | Pharmacol. Biochem. Behav. | pmid:2883669 |
| Westcott JY et al. | Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury. | 1987 | Prostaglandins | pmid:2835791 |
| Goh Y et al. | Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system. | 1987 | Biochim. Biophys. Acta | pmid:3477292 |
| Chiabrando C et al. | Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. | 1987 | Cancer Res. | pmid:3100032 |
| Santoro MG et al. | PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. | 1987 | J. Gen. Virol. | pmid:3033130 |
| Levi-Schaffer F et al. | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. | 1987 | J. Immunol. | pmid:2445814 |
| Kozuka T et al. | Prostaglandin D2 release by guinea pig skin during in vitro anaphylaxis induced by antigen and compound 48/80. | 1987 | J. Invest. Dermatol. | pmid:2433354 |
| Abdel-Malek ZA et al. | In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. | 1987 | Cancer Res. | pmid:2438034 |
| Levi-Schaffer F et al. | Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. | 1987 | J. Immunol. | pmid:2439587 |
| Leung KB et al. | Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue. | 1987 | Agents Actions | pmid:2440274 |
| Church MK et al. | Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. | 1987 | Clin. Allergy | pmid:2441900 |
| Kosaka Y et al. | Oxatomide inhibits the release of bronchoconstrictor arachidonic acid metabolites (iLTC4 and PGD2) from rat mast cells and guinea-pig lung. | 1987 | Agents Actions | pmid:2442981 |
| Pipkorn U et al. | Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge. | 1987 | J. Clin. Invest. | pmid:2443539 |
| Rodriguez R et al. | Effect of nimodipine on arachidonic acid metabolites after subarachnoid hemorrhage. | 1987 | Acta Neurol. Scand. | pmid:3120489 |
| Suzuki F et al. | Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. | 1987 | Biochim. Biophys. Acta | pmid:3467795 |
| Richelsen B | Relationship between binding and action of different prostaglandins in rat adipocytes with special reference to PGE2 and PGI2. | 1987 | Biochem. Pharmacol. | pmid:2825710 |
| Hayashi H et al. | Metabolism of prostaglandin D2 in isolated rat lung: the stereospecific formation of 9 alpha,11 beta-prostaglandin F2 from prostaglandin D2. | 1987 | Biochim. Biophys. Acta | pmid:3467796 |
| Dieter P et al. | Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange. | 1987 | Eur. J. Biochem. | pmid:2826152 |
| Weinreich D and Wonderlin WF | Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. | 1987 | J. Physiol. (Lond.) | pmid:3481834 |
| Nakamura M et al. | In vivo effects of prostaglandins on human retinoblastoma cells in nude mice. | 1987 | Jpn. J. Ophthalmol. | pmid:3482290 |
| Yatomi A et al. | Prostaglandins affect the central nervous system to produce hyperglycemia in rats. | 1987 | Endocrinology | pmid:3474143 |
| Hanasaki K et al. | Beta 2-adrenergic regulation of prostaglandin D2 receptor in rabbit platelets. | 1987 | Biochim. Biophys. Acta | pmid:2880608 |
| Holgate ST et al. | Primary and secondary effector cells in the pathogenesis of bronchial asthma. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3553030 |