PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Astrocytoma D001254 15 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Per page 10 20 50 100 | Total 189

PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

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Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
Norwitz ER et al. Prostaglandin D2 production by term human decidua: cellular origins defined using flow cytometry. 1992 Obstet Gynecol pmid:1495703
Burgermeister E et al. Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. 2003 Oncogene pmid:12813462
Kar R et al. A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells. 2009 Oncogene pmid:19448671
Kim DH et al. 15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue. 2010 Oncogene pmid:20208557
Crabb SJ et al. BAG-1 inhibits PPARgamma-induced cell death, but not PPARgamma-induced transcription, cell cycle arrest or differentiation in breast cancer cells. 2008 Oncol. Rep. pmid:18288403
Takashima T et al. Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. 2005 Oncol. Rep. pmid:15756430
Servidei T et al. The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines. 2004 Oncol. Res. pmid:15301425
Walther U et al. Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway. 2016 Oncotarget pmid:26863638
Yen CC et al. Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. 2014 Oncotarget pmid:24566468
Yuan J et al. M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway. 2017 Oncotarget pmid:28423639
Ogino N et al. Phagocytic activity of cultured retinal pigment epithelial cells from chick embryo: inhibition by melatonin and cyclic AMP, and its reversal by taurine and cyclic GMP. 1983 Ophthalmic Res. pmid:6136017
Woodward DF et al. Marked differential effects of prostanoid metabolites on rabbit intraocular pressure. 1989 Ophthalmic Res. pmid:2626239
Huisingh C and McGwin G Change in prostaglandin expression levels and synthesizing activities. 2013 Ophthalmology pmid:24001535
Rim TH et al. Author reply: To PMID 22858125. 2013 Ophthalmology pmid:24001536
Shim J et al. Change in prostaglandin expression levels and synthesizing activities in dry eye disease. 2012 Ophthalmology pmid:22858125
Sheddan NA and Mulzer J Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues. 2006 Org. Lett. pmid:16805562
Brummond KM et al. The first total synthesis of 15-deoxy-Delta12,14-prostaglandin J2 and the unambiguous assignment of the C14 stereochemistry. 2004 Org. Lett. pmid:14723515
Blázovics A et al. [Cytokines, prostaglandins, nutritive and non-nuitritive factors in inflammatory bowel diseases]. 2004 Orv Hetil pmid:15662752
Fahmi H et al. Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. 2002 Osteoarthr. Cartil. pmid:11869069
Fahmi H et al. 15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. 2002 Osteoarthr. Cartil. pmid:12435328
Ebersberger A et al. Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat. 2011 Pain pmid:21345590
Minami T et al. Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. 1994 Pain pmid:7916452
Masamune A et al. Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells. 2002 Pancreas pmid:11854617
Hashimoto K et al. Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. 2004 Pancreas pmid:15028947
Hashimoto K et al. The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. 2003 Pancreas pmid:12826907
Closa D et al. Prostaglandin D2, F2 alpha, E2, and E1 in early phase of experimental acute necrohemorrhagic pancreatitis in rats. 1994 Pancreas pmid:7509066
Wang Y et al. Peroxisome proliferator-activated receptor gamma agonists enhance lung maturation in a neonatal rat model. 2009 Pediatr. Res. pmid:19262292
Uemura S et al. Inotropic effects of prostaglandin D2 and E1 on the newborn rabbit heart. 1984 Pediatr. Res. pmid:6596550
Zhao H et al. Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats. 2008 Peptides pmid:18180074
Bai G et al. Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. 2009 Peptides pmid:19539681
Zhao H et al. Rubimetide (Met-Arg-Trp) derived from Rubisco exhibits anxiolytic-like activity via the DP1 receptor in male ddY mice. 2008 Peptides pmid:18243414
Shimatsu A et al. Prostaglandin D2 stimulates vasoactive intestinal polypeptide release into rat hypophysial portal blood. 1984 Mar-Apr Peptides pmid:6591147
Peeraully MR et al. Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. 2006 Pflugers Arch. pmid:16924534
Bhattacharya SK and Parmar SS Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism. 1987 Pharm. Res. pmid:2977646
Hagens WI et al. Targeting 15d-prostaglandin J2 to hepatic stellate cells: two options evaluated. 2007 Pharm. Res. pmid:17245650
Eichele K et al. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. 2009 Pharm. Res. pmid:19015962
Csányi G et al. Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. 2008 May-Jun Pharmacol Rep pmid:18622059
Saito R et al. The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats. 1987 Pharmacol. Biochem. Behav. pmid:2883669
Hollingsworth EB and Patrick GA The effects produced by prostaglandin D2 on serotonin turnover and release and tryptophan uptake. 1985 Pharmacol. Biochem. Behav. pmid:2581275
Nielsen JA and Sparber SB Central administration of prostaglandin E2 facilitates while F2 alpha attenuates acute dependence upon morphine rats. 1985 Pharmacol. Biochem. Behav. pmid:3860881
Hollingsworth EB and Patrick GA Involvement of the serotonergic system in the prolongation of pentobarbital sleeping time produced by prostaglandin D2. 1985 Pharmacol. Biochem. Behav. pmid:2859604
D'Onofrio C et al. The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein. 1990 Sep-Oct Pharmacol. Res. pmid:2284244
Reyes-Martin P et al. Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells. 2007 Pharmacol. Res. pmid:17291778
Reyes-Martin P et al. 15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. 2008 Pharmacol. Res. pmid:18456507
Schuligoi R et al. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. 2010 Pharmacology pmid:20559016
Prenn C et al. CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine. 2008 Pharmacology pmid:18212515
Tanaka H et al. Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria. 2003 Pharmacology pmid:12571412
Azuma Y et al. Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. 2004 Pharmacology pmid:15240994
Hayaishi O Molecular mechanisms of sleep-wake regulation: a role of prostaglandin D2. 2000 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:10724461
Murphy PJ et al. Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. 1994 Physiol. Behav. pmid:8047572