| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Philips JB and Lyrene RK | Prostaglandins, related compounds, and the perinatal pulmonary circulation. | 1984 | Clin Perinatol | pmid:6386270 |
| Vincent JE et al. | The effect of 5-(2-chlorobenzyl)-5,6,7,7a-tetrahydro 4H-thieno (3.2-C)-pyridine-2-one hydrochloride (PCR 3787), a metabolite of ticlopidine, on the aggregation of human platelets in vitro and on the aggregation inhibiting action of PGI2 and PGD2. | 1984 | Prostaglandins Leukot Med | pmid:6396655 |
| Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
| Osama H et al. | Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids. | 1983 | Biochim. Biophys. Acta | pmid:6407532 |
| Lifschitz MD | Renal effects of nonsteroidal anti-inflammatory agents. | 1983 | J. Lab. Clin. Med. | pmid:6411840 |
| Ruzicka T et al. | Inhibition of rat mast cell arachidonic acid cyclooxygenase by dapsone. | 1983 | J. Allergy Clin. Immunol. | pmid:6413566 |
| Drummond WH | Persistent pulmonary hypertension of the neonate (persistent fetal circulation syndrome). | 1983 | Adv Pediatr | pmid:6424420 |
| Rao PS et al. | Prostaglandin D2 in canine endotoxic shock. Hemodynamic, hematologic, biochemical, and blood gas analyses. | 1984 | Am. J. Obstet. Gynecol. | pmid:6424477 |
| Schick B et al. | Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. | 1984 | J. Immunol. | pmid:6425408 |
| Bertelé V et al. | Pharmacologic inhibition of thromboxane synthetase and platelet aggregation: modulatory role of cyclooxygenase products. | 1984 | Blood | pmid:6426554 |
| Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
| Ogorochi T et al. | Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. | 1984 | J. Neurochem. | pmid:6427411 |
| Kawamura M and Koshihara Y | Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. | 1984 | Prostaglandins | pmid:6427850 |
| Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
| Gresele P et al. | Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. | 1984 | Biochem. Pharmacol. | pmid:6430299 |
| Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
| Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
| Ikai K et al. | Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice. | 1984 | Prostaglandins | pmid:6435183 |
| Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
| Barrow SE et al. | Measurement of prostaglandin D2 and identification of metabolites in human plasma during intravenous infusion. | 1984 | Prostaglandins | pmid:6441188 |
| Feinstein MB et al. | Reversal of thrombin-induced myosin phosphorylation and the assembly of cytoskeletal structures in platelets by the adenylate cyclase stimulants prostaglandin D2 and forskolin. | 1983 | J. Biol. Chem. | pmid:6571835 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human neuroblastoma cells. | 1983 | Cancer Lett. | pmid:6572553 |
| Kootte AM et al. | The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production. | 1983 | Neth J Med | pmid:6572798 |
| Abelson MB et al. | Aspirin therapy in vernal conjunctivitis. | 1983 | Am. J. Ophthalmol. | pmid:6573138 |
| Gerritsen ME | PGD2 formation in the vasculature: characteristics of rat tail vein prostaglandin endoperoxide-D isomerase. | 1983 | Prostaglandins | pmid:6573722 |
| Simmet T and Jaffe BM | Inhibition of B-16 melanoma growth in vitro by prostaglandin D2. | 1983 | Prostaglandins | pmid:6573723 |
| Kondo K et al. | Effects of intracerebroventricular administration of prostaglandin D2 and angiotensin II on blood pressure in conscious rats. | 1983 | Jpn Heart J | pmid:6574266 |
| Hensby CN et al. | Prostaglandins in human skin disease. | 1983 | Br. J. Dermatol. | pmid:6574787 |
| Higashida H et al. | Cytotoxic action of prostaglandin D2 on mouse neuroblastoma cells. | 1983 | Int. J. Cancer | pmid:6574994 |
| Ohkubo T et al. | Effect of prostaglandin D2 on pain and inflammation. | 1983 | Jpn. J. Pharmacol. | pmid:6576182 |
| Philips JB and Lyrene RK | Persistent pulmonary hypertension and prostaglandin D2. | 1983 | Prog. Clin. Biol. Res. | pmid:6577475 |
| Fukushima M | [Development of antineoplastic prostaglandins]. | 1983 | Gan To Kagaku Ryoho | pmid:6577812 |
| Schulman ES et al. | Purified human basophils and mast cells: current concepts of mediator release. | 1983 | Eur J Respir Dis Suppl | pmid:6578086 |
| Fitzpatrick FA and Wynalda MA | Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. | 1983 | J. Biol. Chem. | pmid:6578214 |
| Juhlin L et al. | Effect of infrared irradiation on the recoverable levels of free arachidonic acid and prostaglandins in human forearm skin. | 1983 | J. Invest. Dermatol. | pmid:6578272 |
| Ruzicka T et al. | Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. | 1983 | J. Invest. Dermatol. | pmid:6578273 |
| Soifer SJ et al. | The developmental effects of prostaglandin D2 on the pulmonary and systemic circulations in the newborn lamb. | 1983 | J. Dev. Physiol. | pmid:6579103 |
| Miyake A et al. | Prostaglandin D2 stimulates secretion of luteinizing hormone from pituitary gland in vitro. | 1983 | Acta Endocrinol. | pmid:6579807 |
| Belegu M et al. | beta-Adrenergic blockade of prostaglandin E2- and D2-induced erythroid colony formation. | 1983 | Am. J. Physiol. | pmid:6579847 |
| Lysz TW et al. | Measurement of prostaglandin biosynthetic capacity in discrete areas of the rabbit hippocampal formation. | 1983 | J. Neurosci. Res. | pmid:6580469 |
| Ishizawa M | Contractile effects of PGD2 and PGF2 alpha on mechanical and electrical activities in longitudinal and circular muscles of the guinea-pig colon. | 1983 | Prostaglandins | pmid:6580679 |
| Bregman MD and Meyskens FL | In vitro modulation of human and murine melanoma growth by prostanoid analogues. | 1983 | Prostaglandins | pmid:6581509 |
| Weichman BM et al. | SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6582266 |
| Abramovich DR et al. | The effect of prostaglandin D2 on the blood vessels of the perfused isolated cotyledon of the human placenta. | 1984 | Br. J. Pharmacol. | pmid:6584189 |
| Chiabrando C et al. | Quantitative profiling of prostaglandins and thromboxane by high-resolution gas chromatography-selected--ion monitoring. | 1983 | J. Chromatogr. | pmid:6584432 |
| Kikawa Y et al. | 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6584883 |
| Sakai T et al. | Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | 1984 | Prostaglandins | pmid:6584941 |
| Imashuku S et al. | [Differentiation induction and potentiation of chemotherapy by PGE1 infusion in patients with neuroblastoma--effect of PGE1 on metastatic potential of neuroblastoma]. | 1984 | Gan To Kagaku Ryoho | pmid:6585182 |
| Nakajima M and Toda N | Neuroeffector actions of prostaglandin D2 on isolated dog mesenteric arteries. | 1984 | Prostaglandins | pmid:6587438 |
| Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |