| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu L et al. | Effect of culture conditions on mast cell eicosanoid synthesis. | 1993 | Prostaglandins | pmid:8493360 |
| Rangachari PK and Betti PA | Biological activity of metabolites of PGD2 on canine proximal colon. | 1993 | Am. J. Physiol. | pmid:8498516 |
| Itabashi S et al. | Late asthmatic response causes peripheral airway hyperresponsiveness in dogs treated with metopirone. | 1993 | Int. Arch. Allergy Immunol. | pmid:8508057 |
| Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
| Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |
| Daugschies A | Oesophagostomum dentatum: population dynamics and synthesis of prostanoids by histotropic stages cultured in vitro. | 1995 | Exp. Parasitol. | pmid:8542999 |
| Osaka T and Hayaishi O | Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. | 1995 | Neurosci. Res. | pmid:8545074 |
| Hardy E et al. | Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. | 1995 | Thromb. Haemost. | pmid:8560425 |
| Cummings JJ | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep. | 1995 | J. Appl. Physiol. | pmid:8567564 |
| Naffah-Mazzacoratti MG et al. | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. | 1995 | Neurochem. Int. | pmid:8574174 |
| Kanamori S et al. | Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa. | 1995 | Clin. Exp. Pharmacol. Physiol. | pmid:8575110 |
| Radziszewski W et al. | Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. | 1995 | Int. J. Cardiol. | pmid:8586470 |
| Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
| Sato T et al. | Decreased hypothalamic prostaglandin D2 and prostaglandin E2 contents during isoflurane anaesthesia in rats. | 1995 | Can J Anaesth | pmid:8590493 |
| Usatiuk PV et al. | [Content of prostaglandins E2 and F1alpha in small intestine epithelium in cattle as a function of age and pathology in non-infectious diarrhea]. | 1995 Mar-Apr | Ukr. Biokhim. Zh. | pmid:8592776 |
| Pandey HP et al. | Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. | 1995 | Biochem. Mol. Biol. Int. | pmid:8595382 |
| Vesin MF et al. | Biosynthesis of prostaglandin D2 by motoneurons and dorsal horn microneurons: a biochemical and high resolution immunocytochemical study in chick spinal cord. | 1995 | Neuroscience | pmid:8596663 |
| Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
| Rozera C et al. | Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block. | 1996 | J. Clin. Invest. | pmid:8621762 |
| Seghaye MC et al. | Histamine liberation related to cardiopulmonary bypass in children: possible relation to transient postoperative arrhythmias. | 1996 | J. Thorac. Cardiovasc. Surg. | pmid:8622322 |
| Longphre M et al. | PAF-induced airways hyperreactivity is modulated by mast cells in mice. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8624251 |
| Chilton FH et al. | Antigen-induced generation of lyso-phospholipids in human airways. | 1996 | J. Exp. Med. | pmid:8642333 |
| Odani N et al. | Induction of protein disulfide isomerase mRNA by delta 12-prostaglandin J2. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645293 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Weidenbach H et al. | Reduction of bile secretion by prostaglandins in the rat in vivo. | 1996 | Life Sci. | pmid:8649182 |
| Satoh S et al. | Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8650205 |
| Kawamoto K | [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]. | 1995 | Hum. Cell | pmid:8652450 |
| Odani N et al. | Regulation of BiP gene expression by cyclopentenone prostaglandins through unfolded protein response element. | 1996 | J. Biol. Chem. | pmid:8663202 |
| Shalev A and Meier CA | Peroxisome proliferator-activated receptors: a nuclear hormone receptor involved in adipocyte differentiation and lipid homeostasis. | 1996 | Eur. J. Endocrinol. | pmid:8664970 |
| de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
| Yang KD et al. | A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. | 1995 | Acta Microbiol Immunol Hung | pmid:8689093 |
| Spannhake EW | Down-regulation of canine airway mast cell function following exposure to ozone in vivo. | 1996 Mar-Apr | Exp. Lung Res. | pmid:8706634 |
| Sakai T | [Molecular cancer epidemiology--the present status and future possibilities]. | 1996 | Nihon Eiseigaku Zasshi | pmid:8720930 |
| Wagenmann M et al. | Unilateral nasal allergen challenge leads to bilateral release of prostaglandin D2. | 1996 | Clin. Exp. Allergy | pmid:8732233 |
| Shiroma T et al. | [Production and metabolism of prostaglandin D2 by cultured chick retinal pigment epithelial cells]. | 1996 | Nippon Ganka Gakkai Zasshi | pmid:8741332 |
| McClay EF et al. | delta 12-Prostaglandin-J2 is cytotoxic in human malignancies and synergizes with both cisplatin and radiation. | 1996 | Cancer Res. | pmid:8752147 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| O'Sullivan S et al. | Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. | 1996 | J. Allergy Clin. Immunol. | pmid:8757220 |
| Patella V et al. | Eosinophil granule proteins activate human heart mast cells. | 1996 | J. Immunol. | pmid:8757629 |
| Casimir DA et al. | Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. | 1996 | Differentiation | pmid:8765050 |
| Urade Y et al. | Prostaglandin D, E, and F synthases. | 1995 | J Lipid Mediat Cell Signal | pmid:8777570 |
| Negishi M et al. | Biological actions of delta 12-prostaglandin J2. | 1995 | J Lipid Mediat Cell Signal | pmid:8777585 |
| Obata T et al. | IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780726 |
| Johnston DE and Kroening C | Stimulation of prostaglandin synthesis in cultured liver cells by CCl4. | 1996 | Hepatology | pmid:8781342 |
| Norwitz ER et al. | Prostaglandin production by human peripheral blood monocytes changes with in vitro differentiation. | 1996 | Prostaglandins | pmid:8792444 |
| Ko FN et al. | Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. | 1996 | J. Pharm. Pharmacol. | pmid:8794990 |
| Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
| Minami T et al. | Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819497 |
| Sharif NA et al. | Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819509 |
| Wang DY et al. | Prostaglandin D2 measurement in nasal secretions is not a reliable marker for mast cell activation in atopic patients. | 1995 | Clin. Exp. Allergy | pmid:8821304 |