| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Basophilic, Acute | D015471 | 9 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Carotid Artery Thrombosis | D002341 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bingham CO et al. | A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. | 1996 | J. Biol. Chem. | pmid:8824228 |
| Chung HS et al. | Heat contact urticaria--a case report. | 1996 | Yonsei Med. J. | pmid:8826790 |
| Conti C et al. | Inhibition of poliovirus replication by prostaglandins A and J in human cells. | 1996 | Antimicrob. Agents Chemother. | pmid:8834882 |
| Woodiel FN et al. | Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway. | 1996 | J. Bone Miner. Res. | pmid:8864899 |
| Knol EF et al. | The role of basophils in allergic disease. | 1996 | Eur Respir J Suppl | pmid:8871057 |
| Kim HS et al. | Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. | 1996 | Prostaglandins | pmid:8873236 |
| Naclerio RM et al. | Origin of late phase histamine release. | 1996 | J. Allergy Clin. Immunol. | pmid:8876545 |
| de Graaf-in t Veld C et al. | Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls. | 1996 | Clin. Exp. Allergy | pmid:8877155 |
| Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
| Ishimoto T et al. | Importance of the phospholipase D-initiated sequential pathway for arachidonic acid release and prostaglandin D2 generation by rat peritoneal mast cells. | 1996 | J. Biochem. | pmid:8902628 |
| Hayaishi O | Tryptophan, oxygenase, and sleep. | 1996 | Adv. Exp. Med. Biol. | pmid:8906236 |
| Urade Y et al. | Molecular mechanism of sleep regulation by prostaglandin D2. | 1996 | J Lipid Mediat Cell Signal | pmid:8906548 |
| Higashiyama K et al. | Induction of c-fos protooncogene transcription and apoptosis by delta 12-prostaglandin J2 in human Pl-21 myeloid leukemia and RC-K8 pre-B lymphoma cells. | 1996 | Prostaglandins | pmid:8908616 |
| Vedin I et al. | Stimulation of tumor necrosis factor-alpha release from lipopolysaccharide-activated human blood monocytes by prostaglandin J2 and metabolites of prostaglandin J2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931117 |
| Santos J et al. | Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. | 1996 | Gastroenterology | pmid:8942724 |
| Ashraf MM et al. | Type II phospholipase A2 is linked to cyclooxygenase-2-mediated delayed prostaglandin D2 generation by cultured mouse mast cells following FcepsilonRI- and cytokine-dependent activation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954964 |
| Ogasawara T et al. | Mouse bone marrow-derived mast cells undergo exocytosis, prostanoid generation, and cytokine expression in response to G protein-activating polybasic compounds after coculture with fibroblasts in the presence of c-kit ligand. | 1997 | J. Immunol. | pmid:8977215 |
| Campbell A et al. | Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. | 1996 | Drugs | pmid:8983912 |
| Takahata R et al. | Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992498 |
| Fiebich BL et al. | Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells. | 1997 | J. Neurochem. | pmid:9003059 |
| Ashraf M et al. | Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1 beta in mouse cultured mast cells. | 1996 | Biochem. J. | pmid:9003387 |
| Reddy ST and Herschman HR | Prostaglandin synthase-1 and prostaglandin synthase-2 are coupled to distinct phospholipases for the generation of prostaglandin D2 in activated mast cells. | 1997 | J. Biol. Chem. | pmid:9013559 |
| Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
| Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
| Hutchinson SM et al. | Effects of eicosanoids on parameters in isolated rat hepatocytes and isolated rat hepatocyte couplets: protective effects of eicosanoid receptor antagonists. | 1997 | J Lipid Mediat Cell Signal | pmid:9041475 |
| Nasushita R et al. | A comparative study of adrenocorticotropin-releasing activity of prostaglandins E1, E2, F2 alpha and D2 in the rat. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051727 |
| Ito H et al. | Prostaglandins stimulate the stress-induced synthesis of hsp27 and alpha B crystallin. | 1997 | J. Cell. Physiol. | pmid:9066782 |
| Bogaards JJ et al. | Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. | 1997 | Chem. Res. Toxicol. | pmid:9084911 |
| Abran D et al. | Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs. | 1997 | Am. J. Physiol. | pmid:9087666 |
| Franzese O et al. | Functional antagonism between IL-2 and PGA1 or PGJ2 in the control of proliferation of human cord blood-derived mononuclear cells. | 1996 | Int. J. Immunopharmacol. | pmid:9089005 |
| Kanamori Y et al. | Migration of neutrophils from blood to tissue: alteration of modulatory effects of prostanoid on superoxide generation in rabbits and humans. | 1997 | Life Sci. | pmid:9096262 |
| Ram A et al. | CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. | 1997 | Brain Res. | pmid:9098570 |
| Taber DF et al. | A nomenclature system for the isoprostanes. | 1997 | Prostaglandins | pmid:9112285 |
| Minami T et al. | Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice. | 1997 | Br. J. Pharmacol. | pmid:9113374 |
| AL-Hader AA et al. | Novel expression of functional luteinizing hormone/chorionic gonadotropin receptors in cultured glial cells from neonatal rat brains. | 1997 | Biol. Reprod. | pmid:9116153 |
| Teixeira MM et al. | Characterization of the prostanoid receptors mediating inhibition of PAF-induced aggregation of guinea-pig eosinophils. | 1997 | Br. J. Pharmacol. | pmid:9146890 |
| Reddy ST et al. | Analysis of the secretory phospholipase A2 that mediates prostaglandin production in mast cells. | 1997 | J. Biol. Chem. | pmid:9153207 |
| Jović N et al. | Do prostaglandins E2, F2 alpha and D2 have a role in the development of idiopathic trigeminal neuralgia? | 1996 May-Jun | Vojnosanit Pregl | pmid:9174396 |
| Genovese A et al. | Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. | 1997 | Clin. Exp. Allergy | pmid:9179431 |
| Harbige LS et al. | Cytokine secretion by human T cell clones is differentially regulated by eicosanoids. | 1997 | Biochem. Soc. Trans. | pmid:9191392 |
| Murakami M et al. | Cyclooxygenase-2-dependent delayed prostaglandin D2 generation is initiated by nerve growth factor in rat peritoneal mast cells: its augmentation by extracellular type II secretory phospholipase A2. | 1997 | J. Immunol. | pmid:9200484 |
| ElAttar TM and Virji AS | Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9223658 |
| Sampson SE et al. | Effect of inhaled prostaglandin D2 in normal and atopic subjects, and of pretreatment with leukotriene D4. | 1997 | Thorax | pmid:9227716 |
| Werman A et al. | Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. | 1997 | J. Biol. Chem. | pmid:9242701 |
| Blom HM et al. | Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study. | 1997 | Clin. Exp. Allergy | pmid:9249272 |
| Murakami M et al. | Detection of secretory phospholipase A2s related but not identical to type IIA isozyme in cultured mast cells. | 1997 | FEBS Lett. | pmid:9280291 |
| Kiriyama M et al. | Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. | 1997 | Br. J. Pharmacol. | pmid:9313928 |
| Kanaoka Y et al. | Cloning and crystal structure of hematopoietic prostaglandin D synthase. | 1997 | Cell | pmid:9323136 |
| Mahmud I et al. | Prostaglandin D synthase in human megakaryoblastic cells. | 1997 | J. Biol. Chem. | pmid:9353279 |
| Howarth PH | Mediators of nasal blockage in allergic rhinitis. | 1997 | Allergy | pmid:9353555 |