| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Persistent Fetal Circulation Syndrome | D010547 | 1 associated lipids |
| Zollinger-Ellison Syndrome | D015043 | 1 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Mastocytosis, Systemic | D034721 | 1 associated lipids |
| Trigeminal Neuralgia | D014277 | 1 associated lipids |
| Epilepsy, Tonic-Clonic | D004830 | 2 associated lipids |
| Cryptorchidism | D003456 | 2 associated lipids |
| Cystitis, Interstitial | D018856 | 2 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kolaczkowska E et al. | Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. | 2009 Nov-Dec | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:19885646 |
| Moreira V et al. | Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19155166 |
| Hayden RE et al. | Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15dDelta12,14,PGJ2. | 2009 | Leukemia | pmid:18923439 |
| Csanky E et al. | Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls. | 2009 | Electrophoresis | pmid:19294692 |
| Kase K et al. | Inhibitory action of roxithromycin on histamine release and prostaglandin D2 production from beta-defensin 2-stimulated mast cells. | 2009 | Int. J. Mol. Med. | pmid:19212651 |
| Ricart KC et al. | The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. | 2009 | Biochem. J. | pmid:19161347 |
| Pirianov G et al. | The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. | 2009 | Endocrinology | pmid:18845626 |
| Tsuji T et al. | Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. | 2009 | Neurochem. Res. | pmid:18946735 |
| Waku T et al. | Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids. | 2009 | J. Mol. Biol. | pmid:18977231 |
| Bruck R et al. | Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. | 2009 | Dig. Dis. Sci. | pmid:18594976 |
| O'Brien JJ et al. | 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. | 2009 | J. Thromb. Haemost. | pmid:18983509 |
| Kalantari P et al. | 15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification. | 2009 | FASEB J. | pmid:19299483 |
| Mohri I et al. | Inhibition of prostaglandin D synthase suppresses muscular necrosis. | 2009 | Am. J. Pathol. | pmid:19359520 |
| Moriai M et al. | Down-regulation of hTERT expression plays an important role in 15-deoxy-Delta12,14-prostaglandin J2-induced apoptosis in cancer cells. | 2009 | Int. J. Oncol. | pmid:19360348 |
| Boehme SA et al. | Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). | 2009 | Int. Immunol. | pmid:19346259 |
| Iinuma K et al. | Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. | 2009 | J. Invest. Dermatol. | pmid:19282842 |
| Boehme SA et al. | A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. | 2009 | Int. Immunol. | pmid:19066314 |
| Boehme SA et al. | Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. | 2009 | Int. Immunol. | pmid:19066315 |
| Ding Q et al. | Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. | 2009 | Endocrinology | pmid:19074584 |
| Schröder R et al. | The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. | 2009 | J. Biol. Chem. | pmid:19010788 |
| Eichele K et al. | R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. | 2009 | Pharm. Res. | pmid:19015962 |
| Gressner OA et al. | Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. | 2009 | Liver Int. | pmid:19018984 |
| Kobayashi M et al. | The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. | 2009 | Mol. Cell. Biol. | pmid:19001094 |
| Irikura D et al. | Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. | 2009 | J. Biol. Chem. | pmid:19131342 |
| Johansson S et al. | CC16 inhibits the migration of eosinophils towards the formyl peptide fMLF but not towards PGD2. | 2009 | Inflammation | pmid:19132521 |
| Kim DH et al. | 15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. | 2009 | Carcinogenesis | pmid:19136476 |
| Di Francesco L et al. | Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. | 2009 | Circ. Res. | pmid:19122175 |
| Wang WM et al. | PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells. | 2009 | Acta Pharmacol. Sin. | pmid:19098936 |
| Tokudome S et al. | Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. | 2009 | J. Clin. Invest. | pmid:19451694 |
| Mickleborough TD et al. | Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. | 2009 | Clin Nutr | pmid:19054597 |
| Arnaud LT et al. | Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells. | 2009 | J. Neurochem. | pmid:19457109 |
| Olmos G et al. | 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. | 2009 | Cell. Mol. Life Sci. | pmid:19458911 |
| Brechbuhl HM et al. | Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport. | 2009 | Free Radic. Biol. Med. | pmid:19520157 |
| Ramji DP | Growth hormone-releasing peptides, CD36, and stimulation of cholesterol efflux: cyclooxygenase-2 is the link. | 2009 | Cardiovasc. Res. | pmid:19520704 |
| Xue L et al. | Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway. | 2009 | J. Immunol. | pmid:19494281 |
| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Chiba T et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces IL-8 and GM-CSF in a human airway epithelial cell line (NCI-H292). | 2009 | Int. Arch. Allergy Immunol. | pmid:19494510 |
| Niki E | Lipid peroxidation: physiological levels and dual biological effects. | 2009 | Free Radic. Biol. Med. | pmid:19500666 |
| Suk FM et al. | 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibits fibrogenic response in human hepatoma cells. | 2009 | Toxicol. Lett. | pmid:19429239 |
| Kansanen E et al. | Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. | 2009 | Free Radic. Biol. Med. | pmid:19573595 |
| Cocca C et al. | 15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest. | 2009 | Biochem. Pharmacol. | pmid:19576185 |
| Thura M et al. | GIF-0173 protects against cerebral infarction through DP1 receptor activation. | 2009 | Exp. Neurol. | pmid:19576888 |
| Bernardo A et al. | Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. | 2009 | J. Neuropathol. Exp. Neurol. | pmid:19535992 |
| Comabella M et al. | Plasma levels of 15d-PGJ are not altered in multiple sclerosis. | 2009 | Eur. J. Neurol. | pmid:19538219 |
| Li H and Pauza CD | Effects of 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) and rosiglitazone on human gammadelta2 T cells. | 2009 | PLoS ONE | pmid:19888466 |
| Landrier JF et al. | Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. | 2009 | Endocrinology | pmid:19833717 |
| Lauring B et al. | Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. | 2009 | J Clin Pharmacol | pmid:19833861 |
| Hironaka A et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19799872 |
| Ohinata K et al. | Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19800413 |
| Davies NJ et al. | AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. | 2009 | Cancer Res. | pmid:19487289 |