| MeSH term | MeSH ID | Detail |
|---|---|---|
| Zollinger-Ellison Syndrome | D015043 | 1 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Mastocytosis, Systemic | D034721 | 1 associated lipids |
| Trigeminal Neuralgia | D014277 | 1 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Persistent Fetal Circulation Syndrome | D010547 | 1 associated lipids |
| Angioedemas, Hereditary | D054179 | 2 associated lipids |
| Epilepsy, Tonic-Clonic | D004830 | 2 associated lipids |
| Cryptorchidism | D003456 | 2 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dong YG et al. | Effects of 15-deoxy-delta12,14-prostaglandin J2 on cell proliferation and apoptosis in ECV304 endothelial cells. | 2004 | Acta Pharmacol. Sin. | pmid:14704122 |
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| Kumar AP et al. | Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. | 2004 | J. Biol. Chem. | pmid:14668325 |
| Böhm E et al. | 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. | 2004 | J. Biol. Chem. | pmid:14668348 |
| Itoh K et al. | Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). | 2004 | Mol. Cell. Biol. | pmid:14673141 |
| Inoue K et al. | Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. | 2004 | Arzneimittelforschung | pmid:15612612 |
| Mitsumori S | Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases. | 2004 | Curr. Pharm. Des. | pmid:15579050 |
| Arai I et al. | Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. | 2004 | Eur. J. Pharmacol. | pmid:15556157 |
| Chen Q et al. | A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. | 2004 | Anal. Biochem. | pmid:15556564 |
| Kim BE et al. | Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. | 2004 | Exp. Mol. Med. | pmid:15557816 |
| Józkowicz A et al. | 15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560113 |
| Alvarez-Maqueda M et al. | 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. | 2004 | J. Biol. Chem. | pmid:15024026 |
| Marone G et al. | The human heart as a shock organ in anaphylaxis. | 2004 | Novartis Found. Symp. | pmid:15025396 |
| Qin C et al. | A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. | 2004 | Mol. Cancer Ther. | pmid:15026545 |
| Hashimoto K et al. | Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. | 2004 | Pancreas | pmid:15028947 |
| Toyomoto M et al. | Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures. | 2004 | FEBS Lett. | pmid:15044028 |
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| Ehara N et al. | Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358182 |
| Yuan ZY et al. | PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. | 2004 | Chin. Med. J. | pmid:15361304 |
| Dugo L et al. | 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. | 2004 | Eur. J. Pharmacol. | pmid:15364008 |
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| Hofnagel O et al. | Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15271788 |
| Park KS et al. | Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. | 2004 | Exp. Cell Res. | pmid:15212945 |
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| Jung KM et al. | Activation of p38 mitogen-activated protein kinase and activator protein-1 during the promotion of neurite extension of PC-12 cells by 15-deoxy-delta12,14-prostaglandin J2. | 2003 | Mol. Pharmacol. | pmid:12606768 |
| Abe M et al. | GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615657 |
| Qin C et al. | Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. | 2003 | Cancer Res. | pmid:12615709 |
| Kajekar R et al. | Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12618420 |
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