| MeSH term | MeSH ID | Detail |
|---|---|---|
| Persistent Fetal Circulation Syndrome | D010547 | 1 associated lipids |
| Zollinger-Ellison Syndrome | D015043 | 1 associated lipids |
| Mastocytosis, Systemic | D034721 | 1 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Trigeminal Neuralgia | D014277 | 1 associated lipids |
| Pulmonary Aspergillosis | D055732 | 1 associated lipids |
| Cystitis, Interstitial | D018856 | 2 associated lipids |
| Decapitation | D049248 | 2 associated lipids |
| Asthma, Aspirin-Induced | D055963 | 2 associated lipids |
| Optic Neuropathy, Ischemic | D018917 | 2 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Wang DY et al. | Prostaglandin D2 measurement in nasal secretions is not a reliable marker for mast cell activation in atopic patients. | 1995 | Clin. Exp. Allergy | pmid:8821304 |
| Hashimoto N et al. | Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate. | 1995 | Hepatology | pmid:7768516 |
| Koizumi T et al. | Identification of a cis-regulatory element for delta 12-prostaglandin J2-induced expression of the rat heme oxygenase gene. | 1995 | J. Biol. Chem. | pmid:7665598 |
| Leal-Berumen I et al. | Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. | 1995 | J. Immunol. | pmid:7536779 |
| Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
| Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
| Rangachari PK et al. | Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? | 1995 | J. Pharmacol. Exp. Ther. | pmid:7473146 |
| Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
| Reanmongkol W et al. | Inhibitory effect of alkaloids extracted from the stem bark of Hunteria zeylanica on 5-lipoxygenase activity in vitro. | 1995 | Biol. Pharm. Bull. | pmid:7550132 |
| Matsumoto K et al. | Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. | 1995 | J. Biochem. | pmid:7608139 |
| Polosa R et al. | Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881647 |
| Butterfield JH et al. | Aspirin idiosyncrasy in systemic mast cell disease: a new look at mediator release during aspirin desensitization. | 1995 | Mayo Clin. Proc. | pmid:7731260 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. | 1995 | Eur Arch Otorhinolaryngol | pmid:7734974 |
| Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
| Downard CD et al. | Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. | 1995 | Clin. Pharmacol. Ther. | pmid:7712673 |
| Leifke E et al. | In vivo comparative study of the seizure- and ischemia-induced synthesis of eicosanoids in the brain of gerbils. | 1994 Sep-Oct | Arch Int Pharmacodyn Ther | pmid:7710301 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Satoh S et al. | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. | 1994 | Neurosci. Res. | pmid:7708292 |
| Rodrigues M et al. | Synergistic antiplatelet action of nitric oxide (NO) with PGD2 and its metabolite PGJ2--relevance for cerebral circulation? | 1994 | J. Physiol. Pharmacol. | pmid:7727795 |
| Warren JB et al. | PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. | 1994 | Am. J. Physiol. | pmid:7515584 |
| Zhou W et al. | Lipid mediator production in acute and chronic pancreatitis in the rat. | 1994 | J. Surg. Res. | pmid:8277767 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965770 |
| Lacal PM et al. | Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7965771 |
| Touqui L et al. | Excretion of platelet activating factor-acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: possible role in the regulation of platelet activating factor release. | 1994 | J. Allergy Clin. Immunol. | pmid:8027488 |
| Murphy PJ et al. | Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. | 1994 | Physiol. Behav. | pmid:8047572 |
| Hoffmann R et al. | Regulation of interleukin-6 receptor expression in rat Kupffer cells: modulation by cytokines, dexamethasone and prostaglandin E2. | 1994 | J. Hepatol. | pmid:7814800 |
| Peden DB et al. | Hydrogen peroxide effects on rat mast cell function. | 1994 | Am. J. Physiol. | pmid:8048546 |
| Ohara H et al. | Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme. | 1994 | Biochim. Biophys. Acta | pmid:7948008 |
| Toth P et al. | Administration of human chorionic gonadotropin affects sleep-wake phases and other associated behaviors in cycling female rats. | 1994 | Brain Res. | pmid:7987667 |
| Kantha SS | Histamine-interleukin-prostaglandin pathway: a hypothesis for a biochemical cycle regulating sleep and wakefulness. | 1994 | Med. Hypotheses | pmid:7935077 |
| Fukushima M et al. | Prostaglandin J2 and related compounds. Mode of action in G1 arrest and preclinical results. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825837 |
| Moussard C et al. | Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846109 |
| Woodward DF and Lawrence RA | Identification of a single (FP) receptor associated with prostanoid-induced Ca2+ signals in Swiss 3T3 cells. | 1994 | Biochem. Pharmacol. | pmid:8185669 |
| Koyama Y and Hayaishi O | Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats. | 1994 | Brain Res. Bull. | pmid:8124575 |
| Gotoh M et al. | Desensitization of prostaglandin F2 alpha receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes. | 1994 | Neurochem. Res. | pmid:8065525 |
| Magnussen H et al. | [Experimental effects of air pollutants on healthy probands and asthmatic patients]. | 1994 | Pneumologie | pmid:8183874 |
| Takasuka M et al. | FTIR spectral study of intramolecular hydrogen bonding in thromboxane A2 receptor agonist (U-46619), prostaglandin (PG)E2, PGD2, PGF2 alpha, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: structure-activity relationships. | 1994 | J. Med. Chem. | pmid:8289201 |
| Ishimoto T et al. | Contribution of phospholipases A2 and D to arachidonic acid liberation and prostaglandin D2 formation with increase in intracellular Ca2+ concentration in rat peritoneal mast cells. | 1994 | Eur. J. Biochem. | pmid:7508386 |
| Frieling T et al. | Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon. | 1994 | Am. J. Physiol. | pmid:8304452 |
| Nukina S et al. | Glycogenolytic effect of adenosine involves ATP from hepatocytes and eicosanoids from Kupffer cells. | 1994 | Am. J. Physiol. | pmid:8304463 |
| Underwood DC et al. | Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301572 |
| Diener M and Gabato D | Thromboxane-like actions of prostaglandin D2 on the contractility of the rat colon in vitro. | 1994 | Acta Physiol. Scand. | pmid:8135127 |
| Grunnet N et al. | Absence of glycogen cycling in cultured rat hepatocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8117107 |
| el-Lati SG et al. | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | 1994 | J. Invest. Dermatol. | pmid:7513741 |
| D'Onofrio C et al. | Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction. | 1994 | Leukemia | pmid:7516027 |
| Okayama Y et al. | In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin. | 1994 | Allergy | pmid:7518654 |
| Darius H et al. | Inhibition of human platelets and polymorphonuclear neutrophils by the potent and metabolically stable prostaglandin D2 analog ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7522176 |
| Takei M and Endo K | Histamine release and calcium concentrations in rat mast cells are dependent on intracellular ATP: effects of prostaglandin D2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7524104 |
| Ko FN et al. | YC-1, a novel activator of platelet guanylate cyclase. | 1994 | Blood | pmid:7527671 |
| Closa D et al. | Prostaglandin D2, F2 alpha, E2, and E1 in early phase of experimental acute necrohemorrhagic pancreatitis in rats. | 1994 | Pancreas | pmid:7509066 |
| Morrow JD et al. | Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. | 1994 | Arch Dermatol | pmid:7979442 |
| Sakuma S et al. | Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048918 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
| Pons F et al. | Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7813544 |
| Levasseur-Acker GM et al. | Effect of furosemide on prostaglandin synthesis by human nasal and bronchial epithelial cells in culture. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8136154 |
| Spatz M et al. | Vasoactive peptides and prostaglandin D2 in human cerebromicrovascular endothelium. | 1994 | J. Auton. Nerv. Syst. | pmid:7836668 |
| Armstrong RA and Talpain E | Comparison of the prostaglandin E (EP) receptor of human neutrophils and HL-60 cells differentiated with DMSO. | 1994 | Prostaglandins | pmid:7878190 |
| Small P et al. | Effects of intensity of early response to allergen on the late phase of both the nose and skin. | 1994 | Ann Allergy | pmid:8092561 |
| Matsumura H et al. | Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7991572 |
| Beckh K et al. | Direct regulation of bile secretion by prostaglandins in perfused rat liver. | 1994 | Hepatology | pmid:8175143 |
| Athari A et al. | Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. | 1994 | Hepatology | pmid:8020883 |
| Hirata M et al. | Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972033 |
| Lahaye DH et al. | Effect of bradykinin on loss of density-dependent growth inhibition of normal rat kidney cells. | 1994 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:7981625 |
| Tudorić N et al. | Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. | 1994 | Int. Arch. Allergy Immunol. | pmid:8111247 |
| Murakami M et al. | Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. | 1994 | J. Biol. Chem. | pmid:8071353 |
| Tran-Thi TA et al. | Effects of hypoxia on the oxygen-dependent metabolism of prostaglandins and adenosine in liver cells. | 1994 | J. Hepatol. | pmid:8071531 |
| Chen WY et al. | The effect of 3-[2-(cyclopropylamino)ethoxy]xanthone on platelet thromboxane formation. | 1994 | Thromb. Res. | pmid:8073410 |
| al Jarad N et al. | Effects of a thromboxane receptor antagonist on prostaglandin D2 and histamine induced bronchoconstriction in man. | 1994 | Br J Clin Pharmacol | pmid:8148229 |
| Amon U et al. | Investigations on plasma levels of mast cell mediators in acute atopic dermatitis. | 1994 | J. Dermatol. Sci. | pmid:8193085 |
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| Awad JA et al. | Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. | 1994 | J. Allergy Clin. Immunol. | pmid:8182221 |
| Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
| Minami T et al. | Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. | 1994 | Pain | pmid:7916452 |
| Wu CC et al. | Antiplatelet effects of clausine-D isolated from Clausena excavata. | 1994 | Biochim. Biophys. Acta | pmid:7918571 |
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| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
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| Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
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| Sawyer MM et al. | Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. | 1993 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:8281741 |
| Matsuo T and Cynader MS | The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. | 1993 | Br J Ophthalmol | pmid:8435410 |
| Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
| Koizumi T et al. | Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione. | 1993 | Biochem. Pharmacol. | pmid:8328983 |
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| Harada T et al. | Arachidonic acid metabolism by isolated and cultured middle ear epithelial cells from the chinchilla. | 1993 | Eur Arch Otorhinolaryngol | pmid:8369117 |
| Takagi T et al. | Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats. | 1993 | Calcif. Tissue Int. | pmid:8369992 |
| Püschel GP et al. | Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. | 1993 | Hepatology | pmid:8244278 |
| Neuschäfer-Rube F et al. | Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. | 1993 | Eur. J. Biochem. | pmid:8425526 |
| Spatz M et al. | Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505058 |
| Casolaro V et al. | Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7505332 |
| Hay DW et al. | Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea. | 1993 | Br. J. Pharmacol. | pmid:7507780 |
| Inase N et al. | Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. | 1993 | Am. J. Respir. Cell Mol. Biol. | pmid:8217194 |
| Itoh Y et al. | [Inhibitory effects of AA-2414, a thromboxane (Tx) A2 receptor antagonist, on U-46619-, prostaglandin (PG) D2- and 9 alpha, 11 beta PGF2-induced contractions of guinea pig tracheas and isolated human bronchi]. | 1993 | Arerugi | pmid:8279967 |
| Liu P et al. | [Effects of magnesium lithospermate B on D-galactosamine induced rat liver injury]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8257841 |