| MeSH term | MeSH ID | Detail |
|---|---|---|
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Ascariasis | D001196 | 3 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rahman A et al. | Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. | 2007 | Eur. J. Pharmacol. | pmid:17112500 |
| Jin YR et al. | Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade. | 2007 | J. Pharmacol. Sci. | pmid:17951980 |
| Petrova LN et al. | Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex. | 2007 | Bull. Exp. Biol. Med. | pmid:18457019 |
| Yamada K et al. | Nose-to-brain delivery of TS-002, prostaglandin D2 analogue. | 2007 | J Drug Target | pmid:17365274 |
| Fionda C et al. | 15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors. | 2007 | J. Immunol. | pmid:17371958 |
| Saleem S et al. | PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury. | 2007 | Eur. J. Neurosci. | pmid:17573924 |
| Wu L et al. | Divergent effects of prostaglandin receptor signaling on neuronal survival. | 2007 | Neurosci. Lett. | pmid:17574754 |
| Hasegawa H et al. | A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production. | 2007 | Blood | pmid:17551094 |
| Ueki S et al. | Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541271 |
| Chiba T et al. | Possible novel receptor for PGD2 on human bronchial epithelial cells. | 2007 | Int. Arch. Allergy Immunol. | pmid:17541272 |
| Lim HJ et al. | 15d-PGJ2 stimulates HO-1 expression through p38 MAP kinase and Nrf-2 pathway in rat vascular smooth muscle cells. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17631927 |
| Olmos G et al. | Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism. | 2007 | Cell. Signal. | pmid:17658243 |
| Xiang Z et al. | 15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells. | 2007 | J Neuroinflammation | pmid:17634127 |
| Ye Y et al. | Activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) by atorvastatin is mediated by 15-deoxy-delta-12,14-PGJ2. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17643887 |
| Desmarais JA et al. | The peroxisome proliferator-activated receptor gamma regulates trophoblast cell differentiation in mink (Mustela vison). | 2007 | Biol. Reprod. | pmid:17615406 |
| Nagai H | [The role of lipid mediators in allergic diseases]. | 2007 | Arerugi | pmid:17615500 |
| Kaplan J et al. | Peroxisome proliferator-activated receptor gamma is required for the inhibitory effect of ciglitazone but not 15-deoxy-Delta 12,14-prostaglandin J2 on the NFkappaB pathway in human endothelial cells. | 2007 | Shock | pmid:17621259 |
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| Chen Y et al. | Prostaglandin D2 suppresses human NK cell function via signaling through D prostanoid receptor. | 2007 | J. Immunol. | pmid:17709490 |
| Li Y et al. | Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonist. | 2007 | J. Am. Chem. Soc. | pmid:17691773 |
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| Meyers CD et al. | Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush. | 2007 | Atherosclerosis | pmid:16945375 |
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| Pérez S et al. | The 2-series prostaglandins suppress VLDL secretion in an inflammatory condition-dependent manner in primary rat hepatocytes. | 2006 | Biochim. Biophys. Acta | pmid:16545597 |
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| Sawai H et al. | Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system. | 2006 | Mol. Cancer Res. | pmid:16547153 |
| Fu YG et al. | Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1. | 2006 | Cancer Lett. | pmid:16412567 |
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| Funovics P et al. | Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16647637 |
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| Rockwell CE et al. | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | 2006 | Mol. Pharmacol. | pmid:16611855 |
| Merwald H et al. | Induction of the 72-kilodalton heat shock protein and protection from ultraviolet B-induced cell death in human keratinocytes by repetitive exposure to heat shock or 15-deoxy-delta(12,14)-prostaglandin J2. | 2006 | Cell Stress Chaperones | pmid:16572732 |
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| Masuda H et al. | 15-deoxy-Delta12,14-prostaglandin J2 attenuates development of cyclophosphamide-induced cystitis in rats. | 2006 | Urology | pmid:16461118 |
| Lee E et al. | Anti-asthmatic activity of an ethanol extract from Saururus chinensis. | 2006 | Biol. Pharm. Bull. | pmid:16462020 |
| Raetz CR et al. | Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. | 2006 | J. Lipid Res. | pmid:16479018 |
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| Damrongsri D et al. | Effects of Delta12-prostaglandin J2 on bone regeneration and growth factor expression in rats. | 2006 | Clin Oral Implants Res | pmid:16441784 |
| Mesquita-Santos FP et al. | Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. | 2006 | J. Immunol. | pmid:16424158 |
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| Diaz BL et al. | Group V secretory phospholipase A2 amplifies the induction of cyclooxygenase 2 and delayed prostaglandin D2 generation in mouse bone marrow culture-derived mast cells in a strain-dependent manner. | 2006 | Biochim. Biophys. Acta | pmid:17064958 |
| Qin S et al. | Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065531 |
| Gyles SL et al. | A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants. | 2006 | Immunology | pmid:17067313 |