| MeSH term | MeSH ID | Detail |
|---|---|---|
| Actinobacillus Infections | D000189 | 4 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Anal Gland Neoplasms | D000694 | 1 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Ascariasis | D001196 | 3 associated lipids |
PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang M et al. | [Apoptosis of human lung cancer cells induced by activated peroxisome proliferator-activated receptor-gamma and its mechanism]. | 2003 | Zhonghua Yi Xue Za Zhi | pmid:12921638 |
| Honda K et al. | Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. | 2003 | J. Exp. Med. | pmid:12925672 |
| Mendez M and LaPointe MC | PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes. | 2003 | Hypertension | pmid:12885795 |
| Li L et al. | Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. | 2003 | Gastroenterology | pmid:12891549 |
| Vosseler CA et al. | Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12859958 |
| Aoun P et al. | Neuroprotective effects of PPARgamma agonists against oxidative insults in HT-22 cells. | 2003 | Eur. J. Pharmacol. | pmid:12860474 |
| Zanoni G et al. | First total synthesis of JS isoprostane. | 2003 | J. Org. Chem. | pmid:12868940 |
| Zahradka P et al. | Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation. | 2003 | Mol. Cell. Biochem. | pmid:12841350 |
| Keelan JA et al. | Cytokines, prostaglandins and parturition--a review. | 2003 | Placenta | pmid:12842412 |
| Chen CW et al. | Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. | 2003 | J. Immunol. | pmid:12847270 |
| Yang L et al. | Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung. | 2003 | J. Biol. Chem. | pmid:12829715 |
| Date M et al. | 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells. | 2003 | Liver Int. | pmid:14986820 |
| Houston KD et al. | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. | 2003 | Cancer Res. | pmid:12649180 |
| Piliponsky AM et al. | Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. | 2003 | Blood | pmid:12393403 |
| Yuan Z et al. | Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. | 2003 | Cardiovasc. Res. | pmid:14499870 |
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| Pavan L et al. | Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process. | 2003 | Carcinogenesis | pmid:12807721 |
| Guyton K et al. | Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. | 2003 | Shock | pmid:12813370 |
| Burgermeister E et al. | Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. | 2003 | Oncogene | pmid:12813462 |
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| Placha W et al. | The effect of PPARgamma ligands on the proliferation and apoptosis of human melanoma cells. | 2003 | Melanoma Res. | pmid:14512786 |
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| Farrow B et al. | Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator. | 2003 | Surgery | pmid:12947319 |
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| Gilroy DW et al. | Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. | 2003 | FASEB J. | pmid:14563690 |
| Pierzchalska M et al. | Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. | 2003 | J. Allergy Clin. Immunol. | pmid:12743569 |
| Okano H et al. | 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma. | 2003 | Lab. Invest. | pmid:14563954 |
| Gao L et al. | Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. | 2003 | J. Biol. Chem. | pmid:12746435 |
| Kanbe E et al. | DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand. | 2003 | Exp. Hematol. | pmid:12691917 |
| Jowsey IR et al. | Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14652005 |
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| Garg TK and Chang JY | Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. | 2003 | BMC Ophthalmol | pmid:12659653 |
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| Komar CM and Curry TE | Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor gamma and P450 side chain cleavage in the rat ovary. | 2003 | Biol. Reprod. | pmid:12700202 |
| Worley JR et al. | Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. | 2003 | J. Biol. Chem. | pmid:14534304 |
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| Ruan XZ et al. | PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. | 2003 | J. Am. Soc. Nephrol. | pmid:12595494 |
| Winnett G et al. | Prostaglandin J2 metabolites inhibit aromatase activity by redox-sensitive mechanisms: potential implications for breast cancer therapy. | 2003 | Int. J. Cancer | pmid:12494466 |
| Kalla R et al. | Loss of microglial ramification in microglia-astrocyte cocultures: involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems. | 2003 | Glia | pmid:12465045 |
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| Saydam O et al. | Transactivator protein BICP0 of bovine herpesvirus 1 (BHV-1) is blocked by prostaglandin D2 (PGD2), which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication. | 2004 | J. Virol. | pmid:15047795 |
| Woolhiser MR et al. | Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. | 2004 | Clin. Immunol. | pmid:15003814 |
| Relic B et al. | 15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts. | 2004 | J. Biol. Chem. | pmid:15004016 |
| Tsuji T et al. | Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. | 2004 | Biol. Pharm. Bull. | pmid:15467193 |
| Konopleva M et al. | Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. | 2004 | Mol. Cancer Ther. | pmid:15486192 |
| Ishii T and Uchida K | Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. | 2004 | Chem. Res. Toxicol. | pmid:15487891 |
| Li Z et al. | Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? | 2004 | J. Neurosci. Res. | pmid:15523637 |
| Levonen AL et al. | Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. | 2004 | Biochem. J. | pmid:14616092 |
| Ehara N et al. | Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358182 |
| Yuan ZY et al. | PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. | 2004 | Chin. Med. J. | pmid:15361304 |
| Dugo L et al. | 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. | 2004 | Eur. J. Pharmacol. | pmid:15364008 |
| Zhao ML et al. | 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. | 2004 | J. Neuroimmunol. | pmid:15265671 |
| Zhang X et al. | Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. | 2004 | Blood | pmid:15265789 |
| Azuma Y et al. | Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937. | 2004 | Pharmacology | pmid:15240994 |
| Zhang C et al. | The novel synthetic oleanane triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) induces apoptosis in Mycosis fungoides/Sézary syndrome cells. | 2004 | J. Invest. Dermatol. | pmid:15245439 |