Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hayaishi O | Prostaglandin D2 and sleep--a molecular genetic approach. | 1999 | J Sleep Res | pmid:10389108 |
Salińska E et al. | Role of Ca2+ release from ryanodine stores in generation of NMDA-induced Ca2+ signal in rabbit hippocampus. | 1999 | Ross Fiziol Zh Im I M Sechenova | pmid:10389178 |
Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
Sarraf P et al. | Loss-of-function mutations in PPAR gamma associated with human colon cancer. | 1999 | Mol. Cell | pmid:10394368 |
O'Sullivan S et al. | Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410385 |
Pelton PD et al. | PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425206 |
Wright DH et al. | A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. | 1999 | Eur. J. Pharmacol. | pmid:10448933 |
Su CG et al. | A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. | 1999 | J. Clin. Invest. | pmid:10449430 |
Obata T et al. | Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. | 1999 | Clin. Exp. Allergy | pmid:10457118 |
Stillman BA et al. | Importance of the extracellular domain for prostaglandin EP(2) receptor function. | 1999 | Mol. Pharmacol. | pmid:10462542 |