PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe T et al. | NADP-linked 15-hydroxyprostaglandin dehydrogenase for prostaglandin D in human blood platelets. | 1982 | Arch. Biochem. Biophys. | pmid:6954879 |
| Sánchez-Gómez FJ et al. | Direct evidence for the covalent modification of glutathione-S-transferase P1-1 by electrophilic prostaglandins: implications for enzyme inactivation and cell survival. | 2007 | Arch. Biochem. Biophys. | pmid:17169324 |
| Koda N et al. | Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS. | 2004 | Arch. Biochem. Biophys. | pmid:15047184 |
| Mueller C et al. | Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. | 2003 | Arch. Biochem. Biophys. | pmid:14522590 |
| Morrow JD et al. | Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. | 1998 | Arch. Biochem. Biophys. | pmid:9578611 |
| Oyama S et al. | A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. | 2014 | Arch. Biochem. Biophys. | pmid:24239863 |
| Grunnet N et al. | Absence of glycogen cycling in cultured rat hepatocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8117107 |
| Herbertsson H et al. | The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit. | 1999 | Arch. Biochem. Biophys. | pmid:10375396 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |
| Ikai K and Fukushima M | Effects of cytotoxic prostaglandin, delta 12-PGJ2 on protein synthesis and cytoskeleton in transformed epidermal cells in culture. | 1990 | Arch. Dermatol. Res. | pmid:1693839 |
| Saarinen JV et al. | Release of histamine and leukotriene C4 in immediate allergic wheal reaction as measured with the microdialysis technique. | 2000 | Arch. Dermatol. Res. | pmid:10966057 |
| Steinbrink K et al. | Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins. | 2000 | Arch. Dermatol. Res. | pmid:11000287 |
| Zhang GY et al. | Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor and extracellular matrix in hypertrophic scar fibroblasts in vitro. | 2009 | Arch. Dermatol. Res. | pmid:19466435 |
| Furutani K et al. | Substance P- and antigen-induced release of leukotriene B4, prostaglandin D2 and histamine from guinea pig skin by different mechanisms in vitro. | 1999 Jul-Aug | Arch. Dermatol. Res. | pmid:10482019 |
| Ikai K et al. | Ear swelling in response to UVB irradiation. | 1986 | Arch. Dermatol. Res. | pmid:3466577 |
| Kang HY et al. | Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. | 2006 | Arch. Dermatol. Res. | pmid:16474974 |
| Nittner-Marszalska M et al. | 9α,11β-PGF2, a Prostaglandin D2 Metabolite, as a Marker of Mast Cell Activation in Bee Venom-Allergic Patients. | 2015 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:25763689 |
| Kolaczkowska E et al. | Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. | 2009 Nov-Dec | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:19885646 |
| Brown MS et al. | Arachidonic acid metabolites during nasal challenge. | 1987 | Arch. Otolaryngol. Head Neck Surg. | pmid:3099812 |
| Kim SJ et al. | Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:17121182 |
| Son MJ et al. | Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:16681032 |
| Hwang GS et al. | Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. | 1998 | Arch. Pharm. Res. | pmid:9868555 |
| Choi YH et al. | New anti-inflammatory formulation containing Synurus deltoides extract. | 2005 | Arch. Pharm. Res. | pmid:16114500 |
| Yang JH et al. | Anti-allergic activity of an ethanol extract from Salviae miltiorrhiza. | 2008 | Arch. Pharm. Res. | pmid:19099230 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
| Lee JJ et al. | The protective effects of paclitaxel on platelet aggregation through the inhibition of thromboxane A2 synthase. | 2010 | Arch. Pharm. Res. | pmid:20361303 |
| Zheng MS et al. | Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. | 2008 | Arch. Pharm. Res. | pmid:18409044 |
| Moon TC et al. | The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2008 | Arch. Pharm. Res. | pmid:18365692 |
| Lee CH and Edwards AM | Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes. | 2003 | Arch. Toxicol. | pmid:12632255 |
| Nakajima N et al. | [Alternation of ion transport of airway epithelium by eicosanoids]. | 2005 | Arerugi | pmid:16407682 |
| Nagai H | [The role of lipid mediators in allergic diseases]. | 2007 | Arerugi | pmid:17615500 |
| Itoh Y et al. | [Inhibitory effects of AA-2414, a thromboxane (Tx) A2 receptor antagonist, on U-46619-, prostaglandin (PG) D2- and 9 alpha, 11 beta PGF2-induced contractions of guinea pig tracheas and isolated human bronchi]. | 1993 | Arerugi | pmid:8279967 |
| Buga GM et al. | L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19965777 |
| Kobayashi K et al. | Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23307871 |
| Lin TN et al. | 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16385084 |
| Hatoum OA et al. | Novel mechanism of vasodilation in inflammatory bowel disease. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141408 |
| Polikandriotis JA et al. | Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16020752 |
| Migita H and Morser J | 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15662020 |
| Marx N et al. | PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073956 |
| Jackson SM et al. | Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10479650 |
| Hofnagel O et al. | Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15271788 |
| Abe M et al. | GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615657 |
| Levonen AL et al. | Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11701476 |
| King VL et al. | Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16514081 |
| Cipollone F et al. | Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15155382 |
| Calnek DS et al. | Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12524224 |
| Jung SM et al. | Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels. | 2007 | Arthritis Res. Ther. | pmid:17612394 |
| Ulivi V et al. | Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. | 2011 | Arthritis Res. Ther. | pmid:21682897 |
| Bianchi A et al. | Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2. | 2005 | Arthritis Res. Ther. | pmid:16277686 |
| Moulin D et al. | Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. | 2005 | Arthritis Rheum. | pmid:15751073 |