Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Diers AR et al. | Modulation of mammary cancer cell migration by 15-deoxy-delta(12,14)-prostaglandin J(2): implications for anti-metastatic therapy. | 2010 | Biochem. J. | pmid:20536428 |
Sanchez-Rodriguez J et al. | The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. | 2005 | Biochem. J. | pmid:15819613 |
GarcÃa-Sáinz JA et al. | Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | 1990 | Biochem. J. | pmid:2375756 |
vom Dahl S et al. | Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. | 1990 | Biochem. J. | pmid:2396991 |
Rodway HA et al. | Lysophosphatidic acid attenuates the cytotoxic effects and degree of peroxisome proliferator-activated receptor gamma activation induced by 15-deoxyDelta12,14-prostaglandin J2 in neuroblastoma cells. | 2004 | Biochem. J. | pmid:15171682 |
Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
Smith JB et al. | Cyclic AMP does not inhibit collagen-induced platelet signal transduction. | 1992 | Biochem. J. | pmid:1375452 |
Ashraf M et al. | Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1 beta in mouse cultured mast cells. | 1996 | Biochem. J. | pmid:9003387 |
Landar A et al. | Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. | 2006 | Biochem. J. | pmid:16268779 |
Shiraki T et al. | Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting. | 2006 | Biochem. J. | pmid:16236024 |
Ricart KC et al. | The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. | 2009 | Biochem. J. | pmid:19161347 |
Williams KA et al. | Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets. | 1987 | Biochem. J. | pmid:2444206 |
Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
Thomson AM et al. | Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase. | 1998 | Biochem. J. | pmid:9657971 |
Levonen AL et al. | Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. | 2004 | Biochem. J. | pmid:14616092 |
Oh JY et al. | Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. | 2008 | Biochem. J. | pmid:18237271 |
Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
Diers AR et al. | Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. | 2010 | Biochem. J. | pmid:19916962 |
Neuschäfer-Rube F et al. | Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. | 2003 | Biochem. J. | pmid:12519077 |
Kuiper J et al. | Cellular communication inside the liver. Binding, conversion and metabolic effect of prostaglandin D2 on parenchymal liver cells. | 1989 | Biochem. J. | pmid:2818563 |
Kinoshita T et al. | Predominance of prostaglandin D2 and I2 in the rat gastric mucosa--analysis by high-performance liquid chromatography. | 1987 | Biochem. Int. | pmid:3555501 |
Fukushima M et al. | Prostaglandin D2, a potential antineoplastic agent. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6953969 |
Ueno R et al. | Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6960896 |
Fukushima M et al. | 9-deoxy-delta 9-prostaglandin D2, a prostaglandin D2 derivative with potent antineoplastic and weak smooth muscle-contracting activities. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6961920 |
Kawabe H et al. | Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2436614 |
Matsuo T et al. | 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14741709 |
Józkowicz A et al. | Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14715242 |
Vosseler CA et al. | Structural requirements of cyclopentenone prostaglandins to induce endothelial cell apoptosis. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12859958 |
Odani N et al. | Induction of protein disulfide isomerase mRNA by delta 12-prostaglandin J2. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645293 |
Yamamoto K et al. | Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3056405 |
Kerr JS et al. | Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558648 |
Koshihara Y and Kawamura M | Prostaglandin D2 stimulates calcification of human osteoblastic cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2930558 |
Kar R et al. | Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20678484 |
Obata T et al. | IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780726 |
Ashraf MM et al. | Type II phospholipase A2 is linked to cyclooxygenase-2-mediated delayed prostaglandin D2 generation by cultured mouse mast cells following FcepsilonRI- and cytokine-dependent activation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954964 |
Doyle MC et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23333326 |
Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
Tsubouchi Y et al. | Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11350047 |
Tsubouchi Y et al. | Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753637 |
Ohno K et al. | Metabolic dehydration of prostaglandin E2 and cellular uptake of the dehydration product: correlation with prostaglandin E2-induced growth inhibition. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3464277 |
Dieter P et al. | Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11027502 |
Tanaka K et al. | Effects of prostaglandin D2 on helper T cell functions. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15044085 |
Chen NG and Han X | Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401521 |
Onozaki A et al. | Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047143 |
Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
Miyazaki Y et al. | Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12150985 |
Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
Soares AF et al. | Covalent binding of 15-deoxy-delta12,14-prostaglandin J2 to PPARgamma. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16198309 |
Kuchinke W et al. | A lung type prostaglandin F synthase is expressed in bovine liver: cDNA sequence and expression in E. coli. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1339268 |
Chowdhury AA et al. | Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21726533 |
Qureshi Z and Cagen LM | Prostaglandins F2 alpha produced by rabbit renal slices is not a metabolite of prostaglandins E2. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803799 |
Nishio T et al. | Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973807 |
Pasvanis S et al. | High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22293191 |
Bamba H et al. | Prostaglandins up-regulate vascular endothelial growth factor production through distinct pathways in differentiated U937 cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873632 |
Goto H et al. | Age-associated decreases in prostaglandin contents in human gastric mucosa. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1510674 |
Chock SP and Schmauder-Chock EA | Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3190706 |
Wong GW et al. | Ancient origin of mast cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:25094046 |
Satoh H et al. | Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. | 1999 | Biochem. Biophys. Res. Commun. | pmid:9920814 |
Ohtani-Fujita N et al. | p53-Independent activation of the gadd45 promoter by Delta12-prostaglandin J2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9792828 |
Niwa Y et al. | Opposite effects of PU.1 on mast cell stimulation. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18680724 |
Engdahl R et al. | 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17532302 |
Ghosh AK et al. | Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18627765 |
Shen ZN et al. | Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15694358 |
Azuma Y et al. | 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11327705 |
Zavoico GB and Feinstein MB | Cytoplasmic Ca2+ in platelets is controlled by cyclic AMP: antagonism between stimulators and inhibitors of adenylate cyclase. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329175 |
Satoh T et al. | Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10222233 |
Hori T et al. | Prostaglandins antagonize fibroblast proliferation stimulated by tumor necrosis factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1993070 |
Ishida A et al. | Characterization of cAMP-dependent proteolysis of GATA-6. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15913546 |
Satarug S et al. | Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18957281 |
Morii H and Watanabe Y | Solubilization of prostaglandin D2 binding protein from porcine temporal cortex. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1989614 |
Saito S et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 induces apoptosis through activation of the CHOP gene in HeLa cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14575689 |
Pandey HP et al. | Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7646520 |
Baregamian N et al. | PPAR-gamma agonist protects against intestinal injury during necrotizing enterocolitis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19114032 |
Sakuma S et al. | Existence of an enzymatic pathway furnishing arachidonic acid for prostaglandin synthesis from arachidonoyl CoA in rabbit kidney medulla. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048918 |
Jowsey IR et al. | Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14652005 |
Keelan JA et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2), a ligand for peroxisome proliferator-activated receptor-gamma, induces apoptosis in JEG3 choriocarcinoma cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471366 |
Shinozawa T et al. | Tetranor PGDM analyses for the amyotrophic lateral sclerosis: positive and simple diagnosis and evaluation of drug effect. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22027143 |
Murakami M et al. | Group II phospholipase A2 inhibitors suppressed lysophosphatidylserine-dependent degranulation of rat peritoneal mast cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1721808 |
Reddy ST et al. | Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10548515 |
Serrero G and Lepak NM | Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626101 |
Ehara N et al. | Activators of PPARgamma antagonize protection of cardiac myocytes by endothelin-1. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358182 |
Gayarre J et al. | Addition of electrophilic lipids to actin alters filament structure. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16979589 |
Erman A and Nasjletti A | Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428405 |
Burgess JR et al. | Enzymatic transformation of PGH2 to PGF2 alpha catalyzed by glutathione S-transferases. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3468949 |
Feinstein MB et al. | The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin). | 1983 | Biochem. Biophys. Res. Commun. | pmid:6307295 |
Wilmer WA et al. | A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11178960 |
Cheng J et al. | Peroxisome proliferator-activated receptor gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2, and ciglitazone, induce growth inhibition and cell cycle arrest in hepatic oval cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15325252 |
Fernández-Tome M et al. | p44/42(ERK1/2) MAPK and PLD activation by PGD2 preserves papillary phosphatidylcholine homeostasis. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15249196 |
Farrow B and Evers BM | Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12535639 |
Hinz B et al. | 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12604364 |
Li Z et al. | Delta12-Prostaglandin J2 inhibits the ubiquitin hydrolase UCH-L1 and elicits ubiquitin-protein aggregation without proteasome inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15194490 |
Hironaka A et al. | 15-Deoxy-Delta(12,14)-prostaglandin J(2) impairs the functions of histone acetyltransferases through their insolubilization in cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19799872 |
Miwa Y et al. | Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15158456 |
Inoue K et al. | Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11563856 |
Chiba Y et al. | PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11511093 |
Andersen NH and Hartzell CJ | High-field 1H NMR studies of prostaglandin H2 and its decomposition pathways. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6587849 |
Yamamoto N et al. | Mechanism of inhibition of herpes simplex virus replication by delta 7-prostaglandin A1 and delta 12-prostaglandin J2. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3040001 |
Zhang J et al. | 15-Deoxy-prostaglandin J(2) inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPAR gamma. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379230 |
Mishra N et al. | Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20307494 |
Hirai H et al. | Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12878180 |