PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miller NR et al. | Sustained neuroprotection from a single intravitreal injection of PGJâ‚‚ in a nonhuman primate model of nonarteritic anterior ischemic optic neuropathy. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25298416 |
| Savinainen JR et al. | Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). | 2014 | PLoS ONE | pmid:25290914 |
| Liu C et al. | 15d-PGJâ‚‚ decreases PGEâ‚‚ synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter. | 2014 | Biochem. Pharmacol. | pmid:25108236 |
| GarcÃa-Bueno B et al. | Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. | 2014 | Schizophr Bull | pmid:23486748 |
| Sturm EM et al. | Opposing roles of prostaglandin D2 receptors in ulcerative colitis. | 2014 | J. Immunol. | pmid:24929001 |
| Steinke JW et al. | Aspirin activation of eosinophils and mast cells: implications in the pathogenesis of aspirin-exacerbated respiratory disease. | 2014 | J. Immunol. | pmid:24890720 |
| Iwanaga K et al. | Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. | 2014 | Cancer Res. | pmid:24879565 |
| Song Y et al. | [PPAR-γ agonist inhibits the expressions of chemokines induced by IFN-γ and TNF-α in renal tubular epithelial cells]. | 2014 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:25001926 |
| Pierron A et al. | PGJ2 restores RA sensitivity in melanoma cells by decreasing PRAME and EZH2. | 2014 | J. Dermatol. Sci. | pmid:24289988 |
| Tachikawa M et al. | Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers. | 2014 | Adv. Pharmacol. | pmid:25307222 |
| Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
| Moreira V et al. | A catalytically-inactive snake venom Lys49 phospholipase Aâ‚‚ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. | 2013 | Eur. J. Pharmacol. | pmid:23416211 |
| Heilmann S et al. | No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. | 2013 | Br. J. Dermatol. | pmid:23448296 |
| Kanda H et al. | COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. | 2013 | Glia | pmid:23505121 |
| Brose SA et al. | A fast one-step extraction and UPLC-MS/MS analysis for E2/D 2 series prostaglandins and isoprostanes. | 2013 | Lipids | pmid:23400687 |
| Li H and Narahara H | 15-Deoxy-Δ(12,14)-prostaglandin J(2) induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines. | 2013 | Int. J. Mol. Med. | pmid:23403520 |
| Murata T et al. | Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23479612 |
| Jabr S et al. | Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23791427 |
| Rahman MS et al. | Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. | 2013 | Appl. Biochem. Biotechnol. | pmid:23817787 |
| Aldrovandi M et al. | Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation. | 2013 | J. Lipid Res. | pmid:23883581 |
| Fujishima H et al. | Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. | 2013 | Ann. Allergy Asthma Immunol. | pmid:23886231 |
| Lu Y et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. | 2013 | Nephron Exp. Nephrol. | pmid:23887394 |
| Takayama F et al. | Possible involvement of aiPLA2 in the phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in microglia. | 2013 | J. Neuroimmunol. | pmid:23850486 |
| Nakamura M et al. | Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. | 2013 | Biomed. Pharmacother. | pmid:23206752 |
| Lewis A et al. | Heterogeneity in the responses of human lung mast cells to stem cell factor. | 2013 | Clin. Exp. Allergy | pmid:23278880 |
| Nozaki Y et al. | PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. | 2013 | Med Mol Morphol | pmid:23397546 |
| Carlson LM et al. | Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. | 2013 | Carcinogenesis | pmid:23349014 |
| Doyle MC et al. | 15-Deoxy-Δ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-κB-dependent mechanism. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23333326 |
| Kobayashi K et al. | Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23307871 |
| Xu F et al. | Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. | 2013 | PLoS ONE | pmid:23372817 |
| Sykes L et al. | The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour. | 2013 | Immunology | pmid:23374103 |
| Nelson AM et al. | Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. | 2013 | J. Invest. Dermatol. | pmid:23190891 |
| Kaikkonen S et al. | Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. | 2013 | Mol. Endocrinol. | pmid:23192983 |
| Schmidt JA et al. | Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. | 2013 | Br. J. Pharmacol. | pmid:23146091 |
| Aukema HM et al. | Dietary fish oil reduces glomerular injury and elevated renal hydroxyeicosatetraenoic acid levels in the JCR:LA-cp rat, a model of the metabolic syndrome. | 2013 | Br. J. Nutr. | pmid:23151363 |
| Labrecque P et al. | Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. | 2013 | PLoS ONE | pmid:23762421 |
| Lu Y et al. | Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappaB and mitogen activated protein kinase pathways in bone marrow derived-mast cells. | 2013 | Biol. Pharm. Bull. | pmid:23719635 |
| Yoo JM et al. | Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. | 2013 | Lipids | pmid:23377981 |
| Buckner MM et al. | 15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. | 2013 | PLoS ONE | pmid:23922794 |
| Huisingh C and McGwin G | Change in prostaglandin expression levels and synthesizing activities. | 2013 | Ophthalmology | pmid:24001535 |
| Rim TH et al. | Author reply: To PMID 22858125. | 2013 | Ophthalmology | pmid:24001536 |
| Kaur R et al. | A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds. | 2013 | J Biomol Screen | pmid:23983232 |
| Liu H et al. | Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites. | 2013 | Neurotoxicology | pmid:23973622 |
| Bogacka I et al. | The involvement of peroxisome proliferator activated receptors (PPARs) in prostaglandin F2α production by porcine endometrium. | 2013 | Reprod Biol | pmid:24287039 |
| Mruwat R et al. | Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. | 2013 | PLoS ONE | pmid:24204651 |
| Fajt ML et al. | Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. | 2013 | J. Allergy Clin. Immunol. | pmid:23506843 |
| Cruse G et al. | A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. | 2013 | Immunity | pmid:23643722 |
| Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
| Ramer R et al. | Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. | 2013 | J. Lipid Res. | pmid:23943857 |
| Penas F et al. | PPARγ ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi. | 2013 | Biochim. Biophys. Acta | pmid:22917565 |