Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kanaoka Y and Urade Y | Hematopoietic prostaglandin D synthase. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895599 |
Nagata K and Hirai H | The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895600 |
Powell WS | A novel PGD(2) receptor expressed in eosinophils. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895601 |
Kabashima K and Narumiya S | The DP receptor, allergic inflammation and asthma. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895602 |
Jabr S et al. | Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23791427 |
Thornhill J and Asselin J | Temperature and hemodynamic changes associated with increased neural damage to global hemispheric hypoxic ischemia by prior prostaglandin E2, D2 and F2alpha administration. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574644 |
Tokuda H et al. | Prostaglandin D2 induces interleukin-6 synthesis via Ca2+ mobilization in osteoblasts: regulation by protein kinase C. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582659 |
Sato TA and Mitchell MD | Preferential production of prostaglandin D2 by lipopolysaccharide stimulated human choriodecidual explants. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16380246 |
ElAttar TM and Virji AS | Inhibition of growth in oral squamous carcinoma cells by cyclopentenone prostaglandins: comparison with chemotherapeutic agents. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9223658 |
Sugimoto M et al. | Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16815697 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Vedin I et al. | Stimulation of tumor necrosis factor-alpha release from lipopolysaccharide-activated human blood monocytes by prostaglandin J2 and metabolites of prostaglandin J2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8931117 |
Kuroyanagi G et al. | Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24813642 |
Nasushita R et al. | A comparative study of adrenocorticotropin-releasing activity of prostaglandins E1, E2, F2 alpha and D2 in the rat. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051727 |
Takahata R et al. | Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992498 |
Bacic F et al. | Prostaglandin D2 in cultured capillary and microvascular endothelium of human brain. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508957 |
Moussard C et al. | Effect of chronic REM sleep deprivation on pituitary, hypothalamus and hippocampus PGE2 and PGD2 biosynthesis in the mouse. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846109 |
Yoshida M et al. | Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519494 |
Sugimoto M et al. | Putative mechanism of the itch-scratch circle: repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17250998 |
Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
Fukushima M | Biological activities and mechanisms of action of PGJ2 and related compounds: an update. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1438462 |
Kim KA et al. | 15d-Deoxy-Delta12,14-prostaglandin J2 modulates collagen type I synthesis in human hepatic stellate cells by inducing oxidative stress. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16098720 |
Crider JY et al. | Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758211 |
Gelir E et al. | Effect of rapid-eye-movement sleep deprivation on rat hypothalamic prostaglandins. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16039105 |
Ito S et al. | Prostaglandin D2: a biochemical perspective. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2510183 |
Virgolini I et al. | Effects of taprostene, a chemically stable prostacyclin analogue, in patients with ischaemic peripheral vascular disease: a placebo controlled double-blind trial. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2514430 |
Mita H et al. | Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359019 |
Tokuda H et al. | Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771907 |
Ikai K et al. | Induction of apoptosis, p53 and heme oxygenase-1 by cytotoxic prostaglandin delta12-PGJ2 in transformed endothelial cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654403 |
Takei M and Endo K | Histamine release and calcium concentrations in rat mast cells are dependent on intracellular ATP: effects of prostaglandin D2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7524104 |
Spatz M et al. | Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505058 |
Moreira V et al. | Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19155166 |
Ikai K et al. | Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630918 |
van der Donk EM et al. | Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1719566 |
Imaizumi T et al. | Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14580366 |
Asano S et al. | Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19616422 |
Berry EB et al. | Differential effects of serum constituents on apoptosis induced by the cyclopentenone prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in WISH epithelial cells. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15253890 |
Virgolini I et al. | Effects of bopindolol on platelet function in hypertension at rest and during exercise. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2143586 |
Son DJ et al. | Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15172681 |
Garcia Palacios V et al. | Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)-prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728175 |
Levine L | Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728177 |
Takai S et al. | Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16876988 |
Viganò T et al. | Stimulus-related difference in the formation of leukotrienes and PGD2 after immunological and non-immunological challenge of human lung parenchyma "in vitro". | 1986 | Prostaglandins Leukot Med | pmid:3020580 |
Todo S et al. | Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. | 1986 | Prostaglandins Leukot Med | pmid:3016753 |
Tanaka A et al. | Antiherpetic action of prostaglandin D2. | 1986 | Prostaglandins Leukot Med | pmid:3029784 |
Horie H et al. | Modulation by prostaglandin D2 of glucagon and insulin secretion in the perfused rat pancreas. | 1983 | Prostaglandins Leukot Med | pmid:6361782 |
Walenga RW et al. | Re-examination of the assay for plasma prostanoids by solid-phase extraction, and radioimmunoassay. | 1985 | Prostaglandins Leukot Med | pmid:3865240 |
Sugiyama T et al. | Platelet prostaglandin D2 dehydrogenase in patients with myeloproliferative disorders. | 1986 | Prostaglandins Leukot Med | pmid:3457389 |
Marsden KA et al. | The effect of prostaglandin D2 (PGD2) on circulating eosinophils. | 1984 | Prostaglandins Leukot Med | pmid:6593748 |
Mahmud I et al. | On the identification and biological properties of prostaglandin J2. | 1984 | Prostaglandins Leukot Med | pmid:6597446 |