PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PGD2?

PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PGD2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Sarcoidosis D012507 13 associated lipids
Pleurisy D010998 20 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cataract D002386 34 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Hyperemia D006940 25 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Peritonitis D010538 38 associated lipids
Urticaria Pigmentosa D014582 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Hematoma D006406 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Fibrosis D005355 23 associated lipids
Ascariasis D001196 3 associated lipids
Thyroid Diseases D013959 8 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Leukodystrophy, Globoid Cell D007965 6 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Peptic Ulcer D010437 19 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Astrocytoma D001254 15 associated lipids
Carotid Artery Thrombosis D002341 7 associated lipids
Nasal Polyps D009298 26 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Erythema D004890 22 associated lipids
Hyperalgesia D006930 42 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Hyperlipidemias D006949 73 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PGD2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PGD2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PGD2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PGD2?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PGD2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PGD2?

Knock-out

Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).

Rodent Model

Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PGD2

Download all related citations
Per page 10 20 50 100 | Total 3138
Authors Title Published Journal PubMed Link
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Padilla J et al. Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. 2000 Ann. N. Y. Acad. Sci. pmid:10818475
Wolfe LS and Pellerin L Arachidonic acid metabolites in the rat and human brain. New findings on the metabolism of prostaglandin D2 and lipoxygenase products. 1989 Ann. N. Y. Acad. Sci. pmid:2570544
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Nowak D et al. Comparison of airway responsiveness to prostaglandin D2 and histamine, methacholine or exercise in healthy and asthmatic subjects. 1991 Ann. N. Y. Acad. Sci. pmid:1952573
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Francis HP et al. The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig. 1991 Ann. N. Y. Acad. Sci. pmid:1835329
Zhao X et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. 2007 Ann. Neurol. pmid:17457822
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Brodsky L et al. Arachidonic acid metabolites in middle ear effusions of children. 1991 Ann. Otol. Rhinol. Laryngol. pmid:1648326
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Chen SY et al. 15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. 2002 Anticancer Drugs pmid:12187333
Eucker J et al. Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. 2004 Anticancer Drugs pmid:15514564
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Eucker J et al. Peroxisome proliferator-activated receptor-gamma ligands inhibit proliferation and induce apoptosis in mantle cell lymphoma. 2006 Anticancer Drugs pmid:16926626
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Pica F et al. Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication. 2000 Antimicrob. Agents Chemother. pmid:10602750
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Jozkowicz A et al. Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. 2002 Antioxid. Redox Signal. pmid:12230869
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Rahman MS et al. Cultured preadipocytes undergoing stable transfection with cyclooxygenase-1 in the antisense direction accelerate adipogenesis during the maturation phase of adipocytes. 2013 Appl. Biochem. Biotechnol. pmid:23817787
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