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Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. |
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Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. |
2008 |
Endocrinology |
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Contribution of prostaglandin D2 via prostanoid DP receptor to nasal hyperresponsiveness in guinea pigs repeatedly exposed to antigen. |
2008 |
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15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor. |
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Formation of eicosanoids, E2/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain. |
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AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells. |
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Mol. Cell. Endocrinol. |
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Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. |
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Loss of XIAP sensitizes colon cancer cells to PPARgamma independent antitumor effects of troglitazone and 15-PGJ2. |
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7beta-hydroxy-epiandrosterone modulation of 15-deoxy-delta12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells. |
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Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. |
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Blood |
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Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. |
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Am. J. Nephrol. |
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Comparison of short term in vitro cultured human mast cells from different progenitors - Peripheral blood-derived progenitors generate highly mature and functional mast cells. |
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J. Immunol. Methods |
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15-Deoxy-delta12,14-prostaglandin-J(2) up-regulates cyclooxygenase-2 but inhibits prostaglandin-E(2) production through a thiol antioxidant-sensitive mechanism. |
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Pharmacol. Res. |
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NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. |
2008 |
Neurotoxicology |
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Modulation of cyclooxygenase in endothelial cells by fibronectin: relevance to angiogenesis. |
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J. Cell. Biochem. |
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A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils. |
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Eur. J. Clin. Invest. |
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Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. |
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15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. |
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Mol. Cancer Ther. |
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Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma. |
2008 |
Allergol Int |
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Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. |
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Cancer Detect. Prev. |
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Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. |
2008 |
Allergol Int |
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TGF-beta1 attenuates mediator release and de novo Kit expression by human skin mast cells through a Smad-dependent pathway. |
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J. Immunol. |
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Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. |
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Mol Pain |
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Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. |
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Different effects of spinally applied prostaglandin D2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation. |
2008 |
Neuroscience |
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Opposite effects of PU.1 on mast cell stimulation. |
2008 |
Biochem. Biophys. Res. Commun. |
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Prostaglandin D2 receptors DP and CRTH2 in the pathogenesis of asthma. |
2008 |
Curr. Mol. Med. |
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Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major. |
2008 |
Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |
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15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase. |
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15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. |
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Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. |
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J. Hepatol. |
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Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). |
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J. Pharmacol. Exp. Ther. |
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Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. |
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Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury. |
2008 |
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Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. |
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J. Leukoc. Biol. |
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Regulation of TLR2 expression by prostaglandins in brain glia. |
2008 |
J. Immunol. |
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An endogenous prostaglandin enhances environmental phthalate-induced apoptosis in bone marrow B cells: activation of distinct but overlapping pathways. |
2008 |
J. Immunol. |
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Down-regulation of X-linked inhibitor of apoptosis synergistically enhanced peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition in colon cancer. |
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Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. |
2008 |
Prostaglandins Other Lipid Mediat. |
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Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases. |
2008 |
Toxicon |
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Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. |
2008 |
Mol. Hum. Reprod. |
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Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production. |
2008 |
Int. Arch. Allergy Immunol. |
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Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. |
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Nutr J |
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Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins. |
2008 |
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A negative regulator of delayed prostaglandin D2 production in mouse mast cells. |
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Biochim. Biophys. Acta |
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The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. |
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J. Immunol. |
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PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells. |
2008 |
Br. J. Cancer |
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7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. |
2008 |
Steroids |
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The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. |
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J. Immunol. |
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Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. |
2008 |
Biochim. Biophys. Acta |
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Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor. |
2008 |
Biochem. Biophys. Res. Commun. |
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15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. |
2008 |
Antioxid. Redox Signal. |
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PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells. |
2008 |
J. Neurochem. |
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Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. |
2008 |
Hepatology |
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PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells. |
2008 |
Virology |
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15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. |
2008 |
Blood |
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Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. |
2008 |
J. Immunol. |
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Peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J2, reduces neutrophil migration via a nitric oxide pathway. |
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J. Immunol. |
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Carbon monoxide-prostaglandin E2 interaction in the hypothalamic circulation. |
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Neuroreport |
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Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. |
2008 |
Gene |
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Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. |
2008 |
Endocrinology |
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On the mechanism of inhibition of p27 degradation by 15-deoxy-Delta12,14-prostaglandin J2 in lymphoblasts of Alzheimer's disease patients. |
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Cell. Mol. Life Sci. |
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Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. |
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J. Neurochem. |
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Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. |
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Effects of 15-deoxy-Delta12, 14 prostaglandin J2 and ciglitazone on human cancer cell cycle progression and death: the role of PPARgamma. |
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Eur. J. Pharmacol. |
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Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species. |
2008 |
J Sex Med |
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Peroxisome proliferator-activated receptor-gamma agonists attenuate angiotensin II-induced collagen type I expression in adventitial fibroblasts. |
2008 |
Clin. Exp. Pharmacol. Physiol. |
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15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses. |
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Chem. Res. Toxicol. |
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SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-beta1 by regulating JAK2/STAT3 signaling in pancreas. |
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Int. J. Biochem. Cell Biol. |
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Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. |
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J. Allergy Clin. Immunol. |
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Peroxisome proliferator-activated receptor-gamma protects against hepatic ischemia/reperfusion injury in mice. |
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Hepatology |
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The flavonoid luteolin inhibits niacin-induced flush. |
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Br. J. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J2 induces chemokine expression, oxidative stress and microfilament reorganization in bovine mammary epithelial cells. |
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J. Dairy Res. |
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Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma. |
2008 |
J. Immunol. |
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Met-Arg-Trp derived from Rubisco lowers blood pressure via prostaglandin D(2)-dependent vasorelaxation in spontaneously hypertensive rats. |
2008 |
Peptides |
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Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
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15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. |
2008 |
Carcinogenesis |
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CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine. |
2008 |
Pharmacology |
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Novel biphasic role for lymphocytes revealed during resolving inflammation. |
2008 |
Blood |
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Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells. |
2008 |
Biochem. Biophys. Res. Commun. |
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Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction. |
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Annu. Rev. Immunol. |
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Inhibition of basic secretagogue-induced signaling in mast cells by cell permeable G alpha i-derived peptides. |
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Int. Arch. Allergy Immunol. |
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Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture. |
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Neurochem. Res. |
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Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts. |
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Br. J. Pharmacol. |
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Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility. |
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Eur. J. Pharmacol. |
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Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. |
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Atherosclerosis |
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CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. |
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Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. |
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Vet. Immunol. Immunopathol. |
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Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. |
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Prostaglandins Other Lipid Mediat. |
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Chemical constituents of Melandrium firmum Rohrbach and their anti-inflammatory activity. |
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Arch. Pharm. Res. |
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Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. |
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J Pain |
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Gene alterations by peroxisome proliferator-activated receptor gamma agonists in human colorectal cancer cells. |
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The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. |
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A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. |
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Nephrol. Dial. Transplant. |
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Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. |
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(-)-epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts. |
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Prostaglandins Leukot. Essent. Fatty Acids |
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Rev Alerg Mex |
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