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Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. |
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Neuroscientist |
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Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. |
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Immunology |
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Life Sci. |
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PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts. |
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Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. |
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Molecular genetic studies on sleep-wake regulation, with special emphasis on the prostaglandin D(2) system. |
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Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2. |
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15-Deoxy-delta12,14-prostaglandin J2 induces apoptosis of a thyroid papillary cancer cell line (CG3 cells) through increasing intracellular iron and oxidative stress. |
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Anticancer Drugs |
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Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha. |
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Biochem. Pharmacol. |
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Retinal capillary pericyte proliferation and c-Fos mRNA induction by prostaglandin D2 through the cAMP response element. |
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Invest. Ophthalmol. Vis. Sci. |
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Cytokine |
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PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. |
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Lab. Invest. |
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Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma. |
2002 |
Br. J. Cancer |
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Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. |
2002 |
Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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A proinflammatory role for the cyclopentenone prostaglandins at low micromolar concentrations: oxidative stress-induced extracellular signal-regulated kinase activation without NF-kappa B inhibition. |
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Cell. Signal. |
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Prostaglandin D2 inhibits fibroblast migration. |
2002 |
Eur. Respir. J. |
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2002 |
J. Pharm. Pharmacol. |
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Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages. |
2002 |
J. Immunol. |
pmid:11971025
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Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid. |
2002 |
Immunology |
pmid:11972632
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Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. |
2002 |
Free Radic. Biol. Med. |
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[The roles of the prostanoids played in the body]. |
2002 |
Nippon Yakurigaku Zasshi |
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Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. |
2002 |
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Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids. |
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Biochem. Pharmacol. |
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In vitro pharmacological characterization of the prostanoid receptor population in the non-pregnant porcine myometrium. |
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Eur. J. Pharmacol. |
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Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. |
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Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. |
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J. Toxicol. Environ. Health Part A |
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Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR. |
2002 |
Am. J. Physiol., Cell Physiol. |
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Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. |
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Clin. Immunol. |
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Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. |
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Genes Immun. |
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The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation. |
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Mol. Pharmacol. |
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15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. |
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Kidney Int. |
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Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. |
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Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. |
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Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. |
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MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species. |
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Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone. |
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Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects. |
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J. Acquir. Immune Defic. Syndr. |
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15-deoxy-delta12,14-Prostaglandin J2 inhibits tissue factor expression in human macrophages and endothelial cells: evidence for ERK1/2 signaling pathway blockade. |
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Thromb. Haemost. |
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Inhibitory properties of antitumor prostaglandins against topoisomerases. |
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Biosci. Biotechnol. Biochem. |
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Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2). |
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Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea-pig isolated small intestine. |
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Br. J. Pharmacol. |
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Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. |
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Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. |
2002 |
Biochim. Biophys. Acta |
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PPARgamma and vascular inflammation: adding another piece to the puzzle. |
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Circ. Res. |
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Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2). |
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Exp. Mol. Med. |
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Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma. |
2002 |
J. Invest. Dermatol. |
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Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. |
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J. Invest. Dermatol. |
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Effect of prostaglandin-J(2) on VEGF synthesis depends on the induction of heme oxygenase-1. |
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Antioxid. Redox Signal. |
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The peroxisome proliferator-activated receptor gamma ligand 15-deoxy-Delta12,14-prostaglandin J2 induces vascular endothelial growth factor in the hormone-independent prostate cancer cell line PC 3 and the urinary bladder carcinoma cell line 5637. |
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Int. J. Oncol. |
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15-Deoxy-delta12,14-prostaglandin J2-induced apoptosis does not require PPARgamma in breast cancer cells. |
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J. Lipid Res. |
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15-Deoxy-D12,14-prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells. |
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Immunol. Cell Biol. |
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Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. |
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Phytother Res |
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Modulation of nitric oxide concentration and lipid metabolism by 15-deoxy Delta12,14prostaglandin J2 in embryos from control and diabetic rats during early organogenesis. |
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Reproduction |
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Prostaglandin D2 : a Cinderella of vascular cell biology? |
2002 |
J. Hypertens. |
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Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. |
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J. Hypertens. |
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Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. |
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Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells. |
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Int J Gastrointest Cancer |
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The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. |
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Int J Gastrointest Cancer |
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Adv. Exp. Med. Biol. |
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Adv. Exp. Med. Biol. |
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Thrombomodulin expression by THP-1 but not by vascular endothelial cells is upregulated by pioglitazone. |
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Thromb. Res. |
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[Cyclopentenone prostaglandin derivatives as neuroprotective compounds]. |
2002 |
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Calcium-stimulated short-circuit currents in the canine proximal colonic epithelium: effects of DK-PGD2, a metabolite of prostaglandin D2. |
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Can. J. Physiol. Pharmacol. |
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Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. |
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Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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[Neurotrophin-like low molecular weight compounds]. |
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Nippon Yakurigaku Zasshi |
pmid:12491808
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Influence of vitamin E on mast cell mediator release. |
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Vet. Dermatol. |
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15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes. |
2002 |
Osteoarthr. Cartil. |
pmid:12435328
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Gene expression of prostanoid forming enzymes along the rat nephron. |
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Kidney Int. |
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A comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma. |
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Clin. Exp. Allergy |
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15-Deoxy-prostaglandin J(2) inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPAR gamma. |
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Biochem. Biophys. Res. Commun. |
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Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion. |
2002 |
Clin. Exp. Metastasis |
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