Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yang G et al. | Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism. | 2012 | PLoS ONE | pmid:22899986 |
Nicholson JD et al. | PGJ(2) provides prolonged CNS stroke protection by reducing white matter edema. | 2012 | PLoS ONE | pmid:23284631 |
Yamaura K et al. | Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D2 production of mast cells in a murine model of allergic contact dermatitis. | 2012 | J Toxicol Sci | pmid:23208428 |
Wang Y et al. | Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22119474 |
Alba G et al. | Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils. | 2012 | PLoS ONE | pmid:23115616 |
Hossain MS et al. | Stable expression of lipocalin-type prostaglandin D synthase in cultured preadipocytes impairs adipogenesis program independently of endogenous prostanoids. | 2012 | Exp. Cell Res. | pmid:22100987 |
Paulitschke V et al. | Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. | 2012 | PLoS ONE | pmid:23049949 |
Syeda PK et al. | A monoclonal antibody specific for Δ12-prostaglandin J2 and its utilization in the immunological assay in cell culture system of adipocytes. | 2012 | Hybridoma (Larchmt) | pmid:23098304 |
Gates D et al. | Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism. | 2012 | Biochim. Biophys. Acta | pmid:22138303 |
Weng Y et al. | Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception. | 2012 | Mol Pain | pmid:23013719 |
Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
Ravindra KC et al. | Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438). | 2012 | Chem. Res. Toxicol. | pmid:22141352 |
Maurer M and Church MK | Inflammatory skin responses induced by icatibant injection are mast cell mediated and attenuated by H(1)-antihistamines. | 2012 | Exp. Dermatol. | pmid:22142018 |
Fujimori K et al. | Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. | 2012 | J. Neurochem. | pmid:22043816 |
Bardelli C et al. | Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. | 2012 | Br. J. Pharmacol. | pmid:21745193 |
Chae HS and Chin YW | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854102 |
Miyawaki T et al. | Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854184 |
Maicas N et al. | Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. | 2012 | Arthritis Rheum. | pmid:21898357 |
Kanakasabai S et al. | PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. | 2012 | PLoS ONE | pmid:23185633 |
Kaneko K et al. | Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide. | 2012 | Neuropeptides | pmid:23141054 |
Sedej M et al. | D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on T(H)2 cells. | 2012 | J. Allergy Clin. Immunol. | pmid:21930295 |
Pasvanis S et al. | High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22293191 |
Li X et al. | Natural vanadium-containing Jeju groundwater inhibits immunoglobulin E-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells. | 2012 | Biol. Pharm. Bull. | pmid:22293352 |
Springstead JR et al. | Evidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell function. | 2012 | J. Lipid Res. | pmid:22550136 |
He S et al. | Identification, organ expression and ligand-dependent expression levels of peroxisome proliferator activated receptors in grass carp (Ctenopharyngodon idella). | 2012 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:22079418 |
Hossain MS et al. | Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes. | 2012 | Gene | pmid:22561694 |
Oda A et al. | Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity. | 2012 | J. Neurochem. | pmid:22564055 |
Clemente-Napimoga JT et al. | 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. | 2012 | Life Sci. | pmid:22564409 |
Inceoglu AB et al. | Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22526297 |
Higashi N et al. | Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites. | 2012 | Allergol Int | pmid:22627848 |
Kristensen DM et al. | Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. | 2012 | Int. J. Androl. | pmid:22612476 |
Hogrefe C et al. | Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches. | 2012 | Int. J. Mol. Med. | pmid:22922824 |
Lee E et al. | 15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes. | 2012 | Free Radic. Biol. Med. | pmid:22245093 |
Lee S et al. | Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects. | 2012 | J. Biol. Chem. | pmid:22275363 |
Ledwidge MT et al. | In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin? | 2012 | Atherosclerosis | pmid:22326030 |
Baek K et al. | Myeloid Elf-1-like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator-activated receptor γ expression in bone marrow. | 2012 | J. Cell. Physiol. | pmid:22307523 |
Song HH et al. | Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. | 2012 | Am. J. Chin. Med. | pmid:22928836 |
Tachikawa M et al. | A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22931759 |
Fredman G et al. | Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. | 2012 | Sci Rep | pmid:22957142 |
Matzkin ME et al. | Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. | 2012 | Gen. Comp. Endocrinol. | pmid:22974512 |
Myeku N et al. | cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons. | 2012 | Neurosci. Lett. | pmid:22982149 |
Mechiche H et al. | Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. | 2012 | PLoS ONE | pmid:22984630 |
Shim J et al. | Change in prostaglandin expression levels and synthesizing activities in dry eye disease. | 2012 | Ophthalmology | pmid:22858125 |
Chae HS et al. | Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:22229445 |
Nakahigashi K et al. | PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. | 2012 | J. Allergy Clin. Immunol. | pmid:22206772 |
Lu Y et al. | Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. | 2012 | Food Chem. Toxicol. | pmid:22154852 |
Hewson CA et al. | Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22160268 |
Mantel A et al. | Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. | 2012 | J. Invest. Dermatol. | pmid:22170488 |
Farnesi-de-Assunção TS et al. | PPAR-γ agonists, mainly 15d-PGJ(2), reduce eosinophil recruitment following allergen challenge. | 2012 | Cell. Immunol. | pmid:22192475 |
Kuriyan AE et al. | Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring. | 2012 | Exp. Eye Res. | pmid:22178289 |
Yang K et al. | [Changes of prostaglandin D2,carboxypeptidase A3 and platelet activating factor in guinea pig in anaphylactic shock]. | 2012 | Fa Yi Xue Za Zhi | pmid:22812216 |
Komoda T and Nishikawa M | 6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22785490 |
Joo M and Sadikot RT | PGD synthase and PGD2 in immune resposne. | 2012 | Mediators Inflamm. | pmid:22791937 |
Baudouin-Legros M et al. | Long-term CFTR inhibition modulates 15d-prostaglandin J2 in human pulmonary cells. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22481026 |
Weng Z et al. | Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. | 2012 | PLoS ONE | pmid:22470478 |
Takahashi G et al. | The potential role of prostaglandin D2 in nasal congestion observed in a guinea pig model of allergic rhinitis. | 2012 | Int. Arch. Allergy Immunol. | pmid:22472859 |
Abdo H et al. | The omega-6 fatty acid derivative 15-deoxy-Δ¹²,¹â´-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress. | 2012 | J. Physiol. (Lond.) | pmid:22473776 |
Ji Y et al. | Activation of rat intestinal mucosal mast cells by fat absorption. | 2012 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:22461027 |
Cloutier A et al. | The prostanoid 15-deoxy-Δ12,14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. | 2012 | J. Infect. Dis. | pmid:22219346 |
Sykes L et al. | Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Δ(12,14)-prostaglandin J2. | 2012 | Mediators Inflamm. | pmid:22690041 |
Raman P et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22700433 |
Cao DS et al. | Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. | 2012 | PLoS ONE | pmid:22701540 |
Yue L et al. | Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. | 2012 | Bone | pmid:22705147 |
Napimoga MH et al. | Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. | 2012 | J. Immunol. | pmid:22706081 |
Qiu H et al. | Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. | 2012 | Cardiovasc. Res. | pmid:22707158 |
Luyer MD | Enteric neuroprotection. | 2012 | J. Physiol. (Lond.) | pmid:22707588 |
Nagata N and Urade Y | [Sleep-wake regulation by prostaglandin D2 and adenosine]. | 2012 | Brain Nerve | pmid:22647469 |
Fujimori K et al. | Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways. | 2012 | Gene | pmid:22664386 |
Cebola I and Peinado MA | Epigenetic deregulation of the COX pathway in cancer. | 2012 | Prog. Lipid Res. | pmid:22580191 |
Liu X et al. | 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. | 2012 | Eur. J. Cell Biol. | pmid:22560326 |
Gross-Sondej I et al. | [Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease]. | 2012 | Pneumonol Alergol Pol | pmid:22370980 |
Han Z et al. | 15-deoxy-Δ12,14 -prostaglandin J2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. | 2012 | Hepatology | pmid:22371273 |
Syeda PK et al. | Generation of monoclonal antibody for 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚ and development of enzyme-linked immunosorbent assay for its quantification in culture medium of adipocytes. | 2012 | Appl. Biochem. Biotechnol. | pmid:22391692 |
Quinteiro MS et al. | The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats. | 2012 | Eur J Pain | pmid:22354681 |
Prage EB et al. | Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2). | 2012 | Biochemistry | pmid:22356188 |
Numazawa S et al. | Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells. | 2012 | Biol. Pharm. Bull. | pmid:22382320 |
Lin YC et al. | The glutathionylation of p65 modulates NF-κB activity in 15-deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-treated endothelial cells. | 2012 | Free Radic. Biol. Med. | pmid:22387200 |
Carsin A et al. | [Physiopathology of aspirin intolerant asthma]. | 2012 | Rev Mal Respir | pmid:22405107 |
Song WL et al. | Niacin and biosynthesis of PGDâ‚‚by platelet COX-1 in mice and humans. | 2012 | J. Clin. Invest. | pmid:22406532 |
Nagata N and Urade Y | [Endogenous sleep-promoting substance]. | 2012 | Nippon Rinsho | pmid:22844810 |
Philipose S et al. | Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation. | 2012 | PLoS ONE | pmid:22870195 |
Mooney JJ et al. | Increased Gsα within blood cell membrane lipid microdomains in some depressive disorders: an exploratory study. | 2013 | J Psychiatr Res | pmid:23490066 |
Keum JH et al. | The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells. | 2013 | Chin J Integr Med | pmid:23494327 |
Zhang S et al. | Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23471341 |
Welter H et al. | Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients. | 2013 | Andrology | pmid:23413143 |
Moreira V et al. | A catalytically-inactive snake venom Lys49 phospholipase Aâ‚‚ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages. | 2013 | Eur. J. Pharmacol. | pmid:23416211 |
Heilmann S et al. | No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia. | 2013 | Br. J. Dermatol. | pmid:23448296 |
Ramer R et al. | COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells. | 2013 | Mol. Cancer Ther. | pmid:23220503 |
Haskew-Layton RE et al. | 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ. | 2013 | J. Neurochem. | pmid:23199167 |
Nakamura M et al. | Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model. | 2013 | Biomed. Pharmacother. | pmid:23206752 |
Xu X et al. | Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: molecular modeling with biological evaluation. | 2013 | Steroids | pmid:23707573 |
Safaralizadeh R et al. | Influence of selenium on mast cell mediator release. | 2013 | Biol Trace Elem Res | pmid:23784732 |
Hellmann J et al. | Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. | 2013 | J. Immunol. | pmid:23785121 |
Moghaddami M et al. | Prostaglandin D(2) in inflammatory arthritis and its relation with synovial fluid dendritic cells. | 2013 | Mediators Inflamm. | pmid:23737645 |
Labrecque P et al. | Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor. | 2013 | PLoS ONE | pmid:23762421 |
Lu Y et al. | Manassantin B isolated from Saururus chinensis inhibits cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Fyn-mediated nuclear factor-kappaB and mitogen activated protein kinase pathways in bone marrow derived-mast cells. | 2013 | Biol. Pharm. Bull. | pmid:23719635 |
Yoo JM et al. | Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. | 2013 | Lipids | pmid:23377981 |
Davidson J et al. | Eicosapentaenoic acid suppression of systemic inflammatory responses and inverse up-regulation of 15-deoxyΔ(12,14) prostaglandin J2 production. | 2013 | Br. J. Pharmacol. | pmid:23586396 |
Fajt ML et al. | Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. | 2013 | J. Allergy Clin. Immunol. | pmid:23506843 |
Napimoga MH et al. | Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner. | 2013 | Int. Immunopharmacol. | pmid:23597428 |