Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Satoh S et al. | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. | 1994 | Neurosci. Res. | pmid:7708292 |
Rodrigues M et al. | Synergistic antiplatelet action of nitric oxide (NO) with PGD2 and its metabolite PGJ2--relevance for cerebral circulation? | 1994 | J. Physiol. Pharmacol. | pmid:7727795 |
Warren JB et al. | PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. | 1994 | Am. J. Physiol. | pmid:7515584 |
Zhou W et al. | Lipid mediator production in acute and chronic pancreatitis in the rat. | 1994 | J. Surg. Res. | pmid:8277767 |
Kantha SS | Histamine-interleukin-prostaglandin pathway: a hypothesis for a biochemical cycle regulating sleep and wakefulness. | 1994 | Med. Hypotheses | pmid:7935077 |
Frieling T et al. | Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon. | 1994 | Am. J. Physiol. | pmid:8304452 |
Nukina S et al. | Glycogenolytic effect of adenosine involves ATP from hepatocytes and eicosanoids from Kupffer cells. | 1994 | Am. J. Physiol. | pmid:8304463 |
Grunnet N et al. | Absence of glycogen cycling in cultured rat hepatocytes. | 1994 | Arch. Biochem. Biophys. | pmid:8117107 |
Takei M and Endo K | Histamine release and calcium concentrations in rat mast cells are dependent on intracellular ATP: effects of prostaglandin D2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7524104 |
Ko FN et al. | YC-1, a novel activator of platelet guanylate cyclase. | 1994 | Blood | pmid:7527671 |
Closa D et al. | Prostaglandin D2, F2 alpha, E2, and E1 in early phase of experimental acute necrohemorrhagic pancreatitis in rats. | 1994 | Pancreas | pmid:7509066 |
Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
Levasseur-Acker GM et al. | Effect of furosemide on prostaglandin synthesis by human nasal and bronchial epithelial cells in culture. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8136154 |
Beckh K et al. | Direct regulation of bile secretion by prostaglandins in perfused rat liver. | 1994 | Hepatology | pmid:8175143 |
al Jarad N et al. | Effects of a thromboxane receptor antagonist on prostaglandin D2 and histamine induced bronchoconstriction in man. | 1994 | Br J Clin Pharmacol | pmid:8148229 |
Amon U et al. | Investigations on plasma levels of mast cell mediators in acute atopic dermatitis. | 1994 | J. Dermatol. Sci. | pmid:8193085 |
Takai T et al. | FcR gamma chain deletion results in pleiotrophic effector cell defects. | 1994 | Cell | pmid:8313472 |
Awad JA et al. | Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. | 1994 | J. Allergy Clin. Immunol. | pmid:8182221 |
Salari H et al. | Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. | 1994 | J. Allergy Clin. Immunol. | pmid:8182231 |
Minami T et al. | Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. | 1994 | Pain | pmid:7916452 |
Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
Leifke E et al. | In vivo comparative study of the seizure- and ischemia-induced synthesis of eicosanoids in the brain of gerbils. | 1994 Sep-Oct | Arch Int Pharmacodyn Ther | pmid:7710301 |
Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
Brouwer A et al. | Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin. | 1995 | Clin. Sci. | pmid:7720347 |
Kawata R et al. | Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. | 1995 | J. Immunol. | pmid:7608559 |
Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
Pandey HP et al. | Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. | 1995 | Biochem. Mol. Biol. Int. | pmid:8595382 |
Vesin MF et al. | Biosynthesis of prostaglandin D2 by motoneurons and dorsal horn microneurons: a biochemical and high resolution immunocytochemical study in chick spinal cord. | 1995 | Neuroscience | pmid:8596663 |
Naffah-Mazzacoratti MG et al. | Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. | 1995 | Neurochem. Int. | pmid:8574174 |
Kanamori S et al. | Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa. | 1995 | Clin. Exp. Pharmacol. Physiol. | pmid:8575110 |
Radziszewski W et al. | Nitric oxide donors induce extrusion of cyclic GMP from isolated human blood platelets by a mechanism which may be modulated by prostaglandins. | 1995 | Int. J. Cardiol. | pmid:8586470 |
Small P and Barrett D | Evaluation of dust and dust mite nasal provocation. | 1995 | Ann. Allergy Asthma Immunol. | pmid:8603280 |
Cummings JJ | Pulmonary vasodilator drugs decrease lung liquid production in fetal sheep. | 1995 | J. Appl. Physiol. | pmid:8567564 |
Negishi M et al. | Biological actions of delta 12-prostaglandin J2. | 1995 | J Lipid Mediat Cell Signal | pmid:8777585 |
Wang DY et al. | Prostaglandin D2 measurement in nasal secretions is not a reliable marker for mast cell activation in atopic patients. | 1995 | Clin. Exp. Allergy | pmid:8821304 |
Kawamoto K | [Flow cytometric analysis of cell cycle for the action mechanism of antineoplastic agents]. | 1995 | Hum. Cell | pmid:8652450 |
Yang KD et al. | A higher production of platelet activating factor in ex vivo heterologously secondary dengue-2 virus infections. | 1995 | Acta Microbiol Immunol Hung | pmid:8689093 |
Forman BM et al. | 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | 1995 | Cell | pmid:8521497 |
Kliewer SA et al. | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | 1995 | Cell | pmid:8521498 |
Hardy E et al. | Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. | 1995 | Thromb. Haemost. | pmid:8560425 |
Osaka T and Hayaishi O | Prostaglandin D2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat. | 1995 | Neurosci. Res. | pmid:8545074 |
Daugschies A | Oesophagostomum dentatum: population dynamics and synthesis of prostanoids by histotropic stages cultured in vitro. | 1995 | Exp. Parasitol. | pmid:8542999 |
Pilbeam CC et al. | Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. | 1995 | J. Bone Miner. Res. | pmid:7785462 |
Johnston SL et al. | Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor. | 1995 | Eur. Respir. J. | pmid:7789486 |
Hashimoto N et al. | Prostanoid secretion by rat hepatic sinusoidal endothelial cells and its regulation by exogenous adenosine triphosphate. | 1995 | Hepatology | pmid:7768516 |
Koizumi T et al. | Identification of a cis-regulatory element for delta 12-prostaglandin J2-induced expression of the rat heme oxygenase gene. | 1995 | J. Biol. Chem. | pmid:7665598 |
Kane GC et al. | Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. | 1995 | Prostaglandins | pmid:8588068 |
Hespeling U et al. | Feedback-inhibition of glucagon-stimulated glycogenolysis in hepatocyte/Kupffer cell cocultures by glucagon-elicited prostaglandin production in Kupffer cells. | 1995 | Hepatology | pmid:7590678 |
Sato T et al. | Decreased hypothalamic prostaglandin D2 and prostaglandin E2 contents during isoflurane anaesthesia in rats. | 1995 | Can J Anaesth | pmid:8590493 |
Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
Parker CW et al. | Modulation of IL-4 production in murine spleen cells by prostaglandins. | 1995 | Cell. Immunol. | pmid:7720090 |
Leal-Berumen I et al. | Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. | 1995 | J. Immunol. | pmid:7536779 |
Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
Rangachari PK et al. | Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? | 1995 | J. Pharmacol. Exp. Ther. | pmid:7473146 |
Hayaishi O and Matsumura H | Prostaglandins and sleep. | 1995 | Adv. Neuroimmunol. | pmid:7496614 |
Fernandes B and Crankshaw D | Functional characterization of the prostanoid DP receptor in human myometrium. | 1995 | Eur. J. Pharmacol. | pmid:7498323 |
Kaye AD et al. | Analysis of thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1995 | Crit. Care Med. | pmid:7528116 |
Peden DB and Dailey L | Modulation of mast cell functions by in vitro ozone exposure. | 1995 | Am. J. Physiol. | pmid:7611432 |
Pandey HP et al. | Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7646520 |
Rabe KF et al. | Hydrogen peroxide contracts human airways in vitro: role of epithelium. | 1995 | Am. J. Physiol. | pmid:7573466 |
Crankshaw DJ and Gaspar V | Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. | 1995 | J. Reprod. Fertil. | pmid:7535849 |
Hartmann K et al. | Effect of CC chemokines on mediator release from human skin mast cells and basophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7580286 |
De Vries GW et al. | An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. | 1995 | Br. J. Pharmacol. | pmid:7582550 |
Negishi M et al. | Involvement of protein kinase in delta 12-prostaglandin J2-induced expression of rat heme oxygenase-1 gene. | 1995 | FEBS Lett. | pmid:7556684 |
Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
Ikai K et al. | Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630918 |
Hu ZQ et al. | An essential role of prostaglandin E on mouse mast cell induction. | 1995 | J. Immunol. | pmid:7636261 |
Boie Y et al. | Molecular cloning and characterization of the human prostanoid DP receptor. | 1995 | J. Biol. Chem. | pmid:7642548 |
Murakami M et al. | IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. | 1995 | J. Immunol. | pmid:7594606 |
Terao A et al. | Roles of prostaglandins D2 and E2 in interleukin-1-induced activation of norepinephrine turnover in the brain and peripheral organs of rats. | 1995 | J. Neurochem. | pmid:7595573 |
van Haaster CM et al. | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases. | 1995 | Biochim. Biophys. Acta | pmid:7857988 |
Charlesworth EN | Role of basophils and mast cells in acute and late reactions in the skin. | 1995 | Chem. Immunol. | pmid:7546286 |
Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
Reanmongkol W et al. | Inhibitory effect of alkaloids extracted from the stem bark of Hunteria zeylanica on 5-lipoxygenase activity in vitro. | 1995 | Biol. Pharm. Bull. | pmid:7550132 |
Refsnes M et al. | On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C. | 1995 | J. Cell. Physiol. | pmid:7650056 |
Matsumoto K et al. | Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. | 1995 | J. Biochem. | pmid:7608139 |
Serrero G and Lepak NM | Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626101 |
Lee JH et al. | Induction of p53 and apoptosis by delta 12-PGJ2 in human hepatocarcinoma SK-HEP-1 cells. | 1995 | FEBS Lett. | pmid:7628635 |
Polosa R et al. | Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881647 |
Urade Y et al. | Prostaglandin D, E, and F synthases. | 1995 | J Lipid Mediat Cell Signal | pmid:8777570 |
Guh JH et al. | Antiplatelet effect of gingerol isolated from Zingiber officinale. | 1995 | J. Pharm. Pharmacol. | pmid:7791032 |
Lanas AI et al. | Non-steroidal anti-inflammatory drugs and prostaglandin effects on pepsinogen secretion by dispersed human peptic cells. | 1995 | Gut | pmid:7797113 |
Grewe M et al. | Interleukin-10 production by cultured human keratinocytes: regulation by ultraviolet B and ultraviolet A1 radiation. | 1995 | J. Invest. Dermatol. | pmid:7798637 |
Horn EH et al. | Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia. | 1995 | Clin. Sci. | pmid:7545563 |
Imamura Y et al. | Mechanism of phospholipase D activation induced by prostaglandin D2 in osteoblast-like cells: function of Ca2+/calmodulin. | 1995 | Cell. Signal. | pmid:7756110 |
Butterfield JH et al. | Aspirin idiosyncrasy in systemic mast cell disease: a new look at mediator release during aspirin desensitization. | 1995 | Mayo Clin. Proc. | pmid:7731260 |
Wang D et al. | Concentrations of chemical mediators in nasal secretions after nasal allergen challenges in atopic patients. | 1995 | Eur Arch Otorhinolaryngol | pmid:7734974 |
Wood-Baker R et al. | The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects. | 1995 | Br J Clin Pharmacol | pmid:7742148 |
Downard CD et al. | Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. | 1995 | Clin. Pharmacol. Ther. | pmid:7712673 |
Usatiuk PV et al. | [Content of prostaglandins E2 and F1alpha in small intestine epithelium in cattle as a function of age and pathology in non-infectious diarrhea]. | 1995 Mar-Apr | Ukr. Biokhim. Zh. | pmid:8592776 |
Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
Lydford SJ et al. | Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. | 1996 | Prostaglandins | pmid:8880898 |
Ko FN et al. | Mechanism of action of p-chlorobiphenyl on the inhibition of platelet aggregation. | 1996 | J. Pharm. Pharmacol. | pmid:8794990 |
Santos J et al. | Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. | 1996 | Gastroenterology | pmid:8942724 |
Woodiel FN et al. | Anabolic effects of prostaglandins in cultured fetal rat calvariae: structure-activity relations and signal transduction pathway. | 1996 | J. Bone Miner. Res. | pmid:8864899 |
Knol EF et al. | The role of basophils in allergic disease. | 1996 | Eur Respir J Suppl | pmid:8871057 |
Obata T et al. | IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8780726 |
Kim HS et al. | Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2. | 1996 | Prostaglandins | pmid:8873236 |
Takahata R et al. | Seasonal variation in levels of prostaglandins D2, E2 and F2(alpha) in the brain of a mammalian hibernator, the Asian chipmunk. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992498 |