PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kerr JS et al. | Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2558648 |
| Kawabe Y et al. | Genesis and recovery of ethanol-induced gastric lesions in rats: possible involvement of prostaglandin D2. | 1989 | Am. J. Gastroenterol. | pmid:2916522 |
| Sakai T et al. | Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells. | 1989 | Cancer Res. | pmid:2917351 |
| Phillips GD and Holgate ST | Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma. | 1989 | J. Appl. Physiol. | pmid:2917934 |
| Ban M et al. | A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. | 1989 | Stroke | pmid:2919414 |
| Bhattacharya SK et al. | Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan-induced paw oedema in rats. | 1989 | J. Pharm. Pharmacol. | pmid:2571705 |
| Zehr BB et al. | Use of segmental airway lavage to obtain relevant mediators from the lungs of asthmatic and control subjects. | 1989 | Chest | pmid:2539958 |
| Benyon RC | The human skin mast cell. | 1989 | Clin. Exp. Allergy | pmid:2667702 |
| Leynadier F | [Mast cells and basophils in asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675683 |
| Hamid-Bloomfield S and Whittle BJ | Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. | 1989 | Br. J. Pharmacol. | pmid:2647205 |
| Kuiper J et al. | The role of prostaglandins in endotoxin stimulated glycogenolysis in the liver. | 1989 | Agents Actions | pmid:2653002 |
| Amano N et al. | The effect of pentobarbital and ether anesthesia on rat brain PGD2 content. | 1989 | Agressologie | pmid:2610292 |
| Shram SI et al. | [Preparation and properties of prostaglandin D2 labelled with tritium with high molar radioactivity]. | 1989 | Bioorg. Khim. | pmid:2590255 |
| Yamada K | [The effect of prostaglandin D2 on rat testicular testosterone levels]. | 1989 | Nihon Naibunpi Gakkai Zasshi | pmid:2591605 |
| Goto H et al. | The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595317 |
| Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
| Trist DG et al. | The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. | 1989 | Br. J. Pharmacol. | pmid:2466517 |
| Triggiani M et al. | Inhibition of histamine and prostaglandin D2 release from human lung mast cells by ciclosporin A. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468619 |
| Charlesworth EN et al. | Cells and secretagogues involved in the human late-phase response. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468620 |
| Church MK et al. | Interaction of neuropeptides with human mast cells. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468622 |
| Charlesworth EN et al. | Cutaneous late-phase response to allergen. Mediator release and inflammatory cell infiltration. | 1989 | J. Clin. Invest. | pmid:2468688 |
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| Church MK et al. | Mast cells, neuropeptides and inflammation. | 1989 | Agents Actions | pmid:2473641 |
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| Emery DL et al. | Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea. | 1989 | J. Appl. Physiol. | pmid:2793725 |
| Stürzebecher S et al. | Effects of PGD2, PGE1, and PGI2-analogues on PGDF-release and aggregation of human gelfiltered platelets. | 1989 | Prog. Clin. Biol. Res. | pmid:2477855 |
| Cohan VL et al. | Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. | 1989 | Am. Rev. Respir. Dis. | pmid:2478059 |
| Reshef A et al. | The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). | 1989 | J. Allergy Clin. Immunol. | pmid:2478604 |
| Marone G et al. | Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion. | 1989 | Life Sci. | pmid:2480501 |
| Giles H et al. | The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. | 1989 | Br. J. Pharmacol. | pmid:2924081 |
| Reiss TF et al. | Local mediator release after antigen challenge of a bronchial segment in allergic dogs. | 1989 | Am. J. Physiol. | pmid:2481982 |
| Levi-Schaffer F and Shalit M | Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells activated with peptides. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2482257 |
| Beasley RC et al. | Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction. | 1989 | J. Appl. Physiol. | pmid:2525122 |
| Raisz LG and Woodiel FN | Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin. | 1989 | Prostaglandins | pmid:2727307 |
| Wolfe LS et al. | Metabolism of prostaglandin D2 by human cerebral cortex into 9 alpha, 11 beta-prostaglandin F2 by an active NADPH-dependent 11-ketoreductase. | 1989 | J. Neurochem. | pmid:2723663 |
| Rodriguez y Baena R et al. | Effects of nicardipine on the ex vivo release of eicosanoids after experimental subarachnoid hemorrhage. | 1989 | J. Neurosurg. | pmid:2585083 |
| Marone G | Control mechanisms of mediator release in human basophils and mast cells. | 1988 Nov-Dec | Immunol. Invest. | pmid:2465995 |
| Mezawa A | [Nasal response to chemical mediators in nasal allergy]. | 1988 | Nippon Jibiinkoka Gakkai Kaiho | pmid:3199260 |
| Casteleijn E et al. | Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication. | 1988 | J. Biol. Chem. | pmid:3284878 |
| Ikai K and Imamura S | Prostaglandin D2 in the skin. | 1988 | Int. J. Dermatol. | pmid:3286543 |
| Hardy CC et al. | Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. | 1988 | J. Appl. Physiol. | pmid:3288608 |
| Pienkowski MM et al. | Prostaglandin D2 and histamine during the immediate and the late-phase components of allergic cutaneous responses. | 1988 | J. Allergy Clin. Immunol. | pmid:3292634 |
| Barr RM et al. | The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin. | 1988 | Br J Clin Pharmacol | pmid:2835975 |
| Ito S et al. | Problems in production of prostaglandin D2-specific antibody. | 1988 | Eicosanoids | pmid:3273218 |
| Hayaishi O | Sleep-wake regulation by prostaglandins D2 and E2. | 1988 | J. Biol. Chem. | pmid:3049580 |
| Casteleijn E et al. | Hormonal control of glycogenolysis in parenchymal liver cells by Kupffer and endothelial liver cells. | 1988 | J. Biol. Chem. | pmid:3422638 |
| Yamamoto K et al. | Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3056405 |
| Kuiper J et al. | Identification of prostaglandin D2 as the major eicosanoid from liver endothelial and Kupffer cells. | 1988 | Biochim. Biophys. Acta | pmid:3126817 |
| Hahn HL | [Inflammatory mediators in the pathogenesis of obstructive bronchial diseases: consequences for therapy]. | 1988 | Verh Dtsch Ges Inn Med | pmid:2905102 |
| Iwai M et al. | Potential role for prostaglandin F2 alpha, D2, E2 and thromboxane A2 in mediating the metabolic and hemodynamic actions of sympathetic nerves in perfused rat liver. | 1988 | Eur. J. Biochem. | pmid:3165341 |
| Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
| Koh T et al. | Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats. | 1988 | Eur. J. Pharmacol. | pmid:2969338 |
| Regal JF | Role of arachidonate metabolites in C5a-induced bronchoconstriction. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841450 |
| Tran-Thi TA et al. | Net prostaglandin release by perfused rat liver after stimulation with phorbol 12-myristate 13-acetate. | 1988 | J. Hepatol. | pmid:3166024 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Nakagomi T et al. | Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries. | 1988 | J. Neurosurg. | pmid:2895803 |
| Negishi M et al. | Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins. | 1988 | J. Biol. Chem. | pmid:2896200 |
| Fukui A et al. | Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:3149561 |
| Vigano T et al. | Prostaglandin synthetase inhibition and formation of lipoxygenase products in immunologically challenged normal human lung parenchyma. | 1988 | Eicosanoids | pmid:3152489 |
| Casteleijn E et al. | Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester. | 1988 | Biochem. J. | pmid:3162673 |
| Ishioka C et al. | Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. | 1988 | Cancer Res. | pmid:3162825 |
| Miadonna A et al. | Mediators and allergic inflammation of human airways. | 1988 | Respiration | pmid:2466314 |
| Soifer SJ et al. | Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension. | 1988 | J. Pediatr. | pmid:3162978 |
| Wasserman SI | Basic mechanisms in asthma. | 1988 | Ann Allergy | pmid:3163472 |
| Barr RM et al. | The release of prostaglandin D2 from human skin in vivo and in vitro during immediate allergic reactions. | 1988 | Br. J. Pharmacol. | pmid:2460180 |
| Sonoki H et al. | [Effects of 3,4-diaminopyridine on the contractions of guinea-pig tracheal smooth muscle induced by histamine and prostaglandin D2]. | 1988 | Nippon Yakurigaku Zasshi | pmid:3163668 |
| Ujihara M et al. | Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | 1988 | Arch. Biochem. Biophys. | pmid:3041912 |
| Foreman D et al. | Anhydrolevuglandin D2 inhibits the uterotonic activity of prostaglandins F2 alpha and D2. | 1988 | Prostaglandins | pmid:3163807 |
| Moore PK et al. | Effect of fibrinopeptides A and B on human and rat platelet aggregation in vitro. | 1988 | Eur. J. Pharmacol. | pmid:3053211 |
| Hirata Y et al. | Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine. | 1988 | J. Biol. Chem. | pmid:3053696 |
| Yang CY et al. | Isolation and culture of two cell populations from chick calvaria by density gradient: prostaglandin synthesis by the cells in culture and coculture. | 1988 | Endocrinology | pmid:2844516 |
| Chock SP and Schmauder-Chock EA | Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3190706 |
| Rodriguez y Baena R et al. | A study on cisternal CSF levels of arachidonic acid metabolites after aneurysmal subarachnoid hemorrhage. | 1988 | J. Neurol. Sci. | pmid:3132538 |
| Casteleijn E et al. | Conditioned media of Kupffer and endothelial liver cells influence protein phosphorylation in parenchymal liver cells. Involvement of prostaglandins. | 1988 | Biochem. J. | pmid:3166374 |
| Hoult JR et al. | Organ selective conversion of prostaglandin D2 to 9 alpha, 11 beta-prostaglandin F2 and its subsequent metabolism in rat, rabbit and guinea pig. | 1988 | Biochem. Pharmacol. | pmid:3178873 |
| Nakamura O et al. | [Antineoplastic effect of prostaglandins on human glioma in athymic nude mice]. | 1988 | No To Shinkei | pmid:3179087 |
| Schulman ES et al. | Differential effects of the complement peptides, C5a and C5a des Arg on human basophil and lung mast cell histamine release. | 1988 | J. Clin. Invest. | pmid:2449462 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Robinson C et al. | The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells. | 1988 | J. Invest. Dermatol. | pmid:2450144 |
| Undem BJ and Adams GK | An analysis of the functional interactions of selected contractile agonists in the guinea pig isolated trachea. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839671 |
| Holgate ST et al. | The contribution of mast cell mediators to acute allergic reactions in human skin and airways. | 1988 | Allergy | pmid:2451448 |
| Schulman ES et al. | Density heterogeneity of human lung mast cells. | 1988 | J. Allergy Clin. Immunol. | pmid:2455745 |
| Rao PS et al. | The effect of prostaglandin D2 on angiotensin converting enzyme. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2845437 |
| Undem BJ et al. | Isoproterenol-induced inhibition of immunoglobulin E-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2459368 |
| Wang D et al. | Aminophylline reduces air-flow-induced constriction in the canine lung periphery. | 1988 | Am. Rev. Respir. Dis. | pmid:3422143 |
| Wendelborn DF et al. | Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3422430 |
| Ohno K et al. | Site and mechanism of growth inhibition by prostaglandins. IV. Effect of cyclopentenone prostaglandins on cell cycle progression of G1-enriched HeLa S3 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361448 |
| Suzuki K et al. | Inhibition of human gingival carcinoma cell growth by prostaglandins. | 1988 | Gen. Pharmacol. | pmid:3162424 |
| Goh Y et al. | Prostaglandin D2 reduces intraocular pressure. | 1988 | Br J Ophthalmol | pmid:3164634 |
| Onoe H et al. | Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3163802 |
| Shohami E et al. | Experimental closed head injury in rats: prostaglandin production in a noninjured zone. | 1988 | Neurosurgery | pmid:3164097 |
| Dieter P et al. | Ca2+ requirement of prostanoid but not of superoxide production by rat Kupffer cells. | 1988 | Eur. J. Biochem. | pmid:2846298 |
| Thierauch KH et al. | Stable 9 beta- or 11 alpha-halogen-15-cyclohexyl-prostaglandins with high affinity to the PGD2-receptor. | 1988 | Prostaglandins | pmid:2847246 |
| Ujihara M et al. | Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats. | 1988 | Arch. Biochem. Biophys. | pmid:3124755 |
| Kashimura M et al. | Prostaglandin D2 diminishes transmucosal potential difference in rat colonic mucosa in vitro in contrast to the increasing effect of prostaglandin E1. | 1988 | Prostaglandins | pmid:2854645 |
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| Morimoto A et al. | Multiple control of fever production in the central nervous system of rabbits. | 1988 | J. Physiol. (Lond.) | pmid:3261794 |
| Robinson C et al. | The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | 1988 | Biochim. Biophys. Acta | pmid:3196723 |
| Miwa N et al. | Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture. | 1988 | J. Neurochem. | pmid:2834513 |
| Armour CL et al. | Prostaglandin F2 alpha augments the response to parasympathetic fibre stimulation in an isolated innervated preparation of rabbit trachea. | 1988 | J Auton Pharmacol | pmid:3198665 |