Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with PGD2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yuan ZY et al. | PPAR-gamma ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. | 2004 | Chin. Med. J. | pmid:15361304 |
Dugo L et al. | 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. | 2004 | Eur. J. Pharmacol. | pmid:15364008 |
Ichiki T et al. | 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369766 |
Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
Monneret G et al. | Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15388786 |
Koizumi T et al. | Induction of heme oxygenase by delta 12-prostaglandin J2 in porcine aortic endothelial cells. | 1992 | Prostaglandins | pmid:1542739 |
Lee DY et al. | Prostaglandin profile and synthetic capacity of the colon: comparison of tissue sources and subcellular fractions. | 1992 | Prostaglandins | pmid:1542741 |
Lappas M et al. | Effect of nuclear factor-kappa B inhibitors and peroxisome proliferator-activated receptor-gamma ligands on PTHrP release from human fetal membranes. | 2004 Sep-Oct | Placenta | pmid:15450387 |
Ray DM et al. | Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. | 2004 | Clin. Immunol. | pmid:15451478 |
Tsuji T et al. | Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells. | 2004 | Biol. Pharm. Bull. | pmid:15467193 |
Giri S et al. | The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. | 2004 | J. Immunol. | pmid:15470065 |
Konopleva M et al. | Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias. | 2004 | Mol. Cancer Ther. | pmid:15486192 |
Ishii T and Uchida K | Induction of reversible cysteine-targeted protein oxidation by an endogenous electrophile 15-deoxy-delta12,14-prostaglandin J2. | 2004 | Chem. Res. Toxicol. | pmid:15487891 |
Hayaishi O et al. | Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. | 2004 | Arch Ital Biol | pmid:15493554 |
Emmans VC et al. | Regulation of cellular processes by PPARgamma ligands in neuroblastoma cells is modulated by the level of retinoblastoma protein expression. | 2004 | Biochem. Soc. Trans. | pmid:15494029 |
Chen HH et al. | Effects of trichloroethylene and perchloroethylene on muscle contractile responses and epithelial prostaglandin release and acetylcholinesterase activity in swine trachea. | 2005 | Toxicol. Sci. | pmid:15496499 |
Piva R et al. | 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. | 2005 | Blood | pmid:15498850 |
Huang H et al. | Peroxisome proliferator-activated receptor gamma ligands improve the antitumor efficacy of thrombospondin peptide ABT510. | 2004 | Mol. Cancer Res. | pmid:15498928 |
Shimakura S and Boland CR | Eicosanoid production by the human gastric cancer cell line AGS and its relation to cell growth. | 1992 | Cancer Res. | pmid:1551103 |
Eucker J et al. | Ligands of peroxisome proliferator-activated receptor gamma induce apoptosis in multiple myeloma. | 2004 | Anticancer Drugs | pmid:15514564 |
Yoshida M et al. | Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519494 |
Li Z et al. | Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish? | 2004 | J. Neurosci. Res. | pmid:15523637 |
Shiraishi Y et al. | Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15528449 |
Nie M et al. | Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. | 2005 | J. Biol. Chem. | pmid:15531761 |
Sabichi AL et al. | Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15533896 |
Subbarayan V et al. | Differential peroxisome proliferator-activated receptor-gamma isoform expression and agonist effects in normal and malignant prostate cells. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15533897 |
Abdelrahman M et al. | The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. | 2004 | Shock | pmid:15545828 |
Chen F | Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. | 2004 | Cancer Res. | pmid:15548674 |
Arai I et al. | Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. | 2004 | Eur. J. Pharmacol. | pmid:15556157 |
Chen Q et al. | A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. | 2004 | Anal. Biochem. | pmid:15556564 |
Kim BE et al. | Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. | 2004 | Exp. Mol. Med. | pmid:15557816 |
Józkowicz A et al. | 15-deoxy-delta12,14-prostaglandin-J2 inhibits expression of eNOS in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15560113 |
Hata AN et al. | Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. | 2005 | Mol. Pharmacol. | pmid:15563582 |
Mitsumori S | Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases. | 2004 | Curr. Pharm. Des. | pmid:15579050 |
Kim YS et al. | Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity. | 2005 | Free Radic. Biol. Med. | pmid:15589375 |
Almishri W et al. | Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15590767 |
Hwang J et al. | Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590897 |
Tsukagoshi H and Kurosawa M | [Bronchial hyperresponsiveness to histamine induced by intravenous administration of prostaglandin D2 (PGD2) in guinea pigs]. | 1992 | Nippon Yakurigaku Zasshi | pmid:1559641 |
Inoue K et al. | Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. | 2004 | Arzneimittelforschung | pmid:15612612 |
Chou YH et al. | The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. | 2005 | Int. J. Biochem. Cell Biol. | pmid:15618017 |
López-Parra M et al. | The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin. | 2005 | J. Hepatol. | pmid:15629510 |
Scher JU and Pillinger MH | 15d-PGJ2: the anti-inflammatory prostaglandin? | 2005 | Clin. Immunol. | pmid:15639643 |
Farrajota K et al. | Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. | 2005 | Arthritis Rheum. | pmid:15641079 |
Liu JJ et al. | Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-gamma ligands induces apoptosis on human myeloid leukemia cells in vitro. | 2005 | Ann. Oncol. | pmid:15642706 |
Motilva V et al. | COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. | 2005 | Int. Immunopharmacol. | pmid:15652766 |
MartÃnez B et al. | The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action. | 2005 | J. Lipid Res. | pmid:15654126 |
Liang X et al. | Prostaglandin D2 mediates neuronal protection via the DP1 receptor. | 2005 | J. Neurochem. | pmid:15659218 |
Migita H and Morser J | 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15662020 |
Blázovics A et al. | [Cytokines, prostaglandins, nutritive and non-nuitritive factors in inflammatory bowel diseases]. | 2004 | Orv Hetil | pmid:15662752 |
Trottein F et al. | Role of the D prostanoid receptor 1 in the modulation of immune and inflammatory responses. | 2004 | Crit. Rev. Immunol. | pmid:15663363 |
O'Reilly KM et al. | Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15665045 |
Lee KJ et al. | Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-g. | 2004 | Exp. Mol. Med. | pmid:15665586 |
Jerde TJ et al. | Celecoxib inhibits ureteral contractility and prostanoid release. | 2005 | Urology | pmid:15667901 |
Figarella K et al. | Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form. | 2005 | Cell Death Differ. | pmid:15678148 |
Tanaka T et al. | Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. | 2005 | Eur. J. Pharmacol. | pmid:15680279 |
Genovese T et al. | Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. | 2005 | Eur. Respir. J. | pmid:15684285 |
Shen ZN et al. | Suppression of chondrosarcoma cells by 15-deoxy-Delta 12,14-prostaglandin J2 is associated with altered expression of Bax/Bcl-xL and p21. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15694358 |
Shiraki T et al. | Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. | 2005 | J. Biol. Chem. | pmid:15695504 |
Bulló M et al. | Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15713689 |
GarcÃa-Bueno B et al. | The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. | 2005 | Psychopharmacology (Berl.) | pmid:15719215 |
Higashihara H et al. | Hypoxia-reoxygenation enhances interleukin-8 production from U937 human monocytic cells. | 2004 | Redox Rep. | pmid:15720834 |
Takagi T et al. | A PPAR-gamma ligand, 15-deoxy-Delta12,14-prostaglandin J(2), inhibited gastric mucosal injury induced by ischemia-reperfusion in rats. | 2004 | Redox Rep. | pmid:15720836 |
Storer PD et al. | Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. | 2005 | J. Neurosci. Res. | pmid:15723383 |
Sasaguri T et al. | Prostaglandins A and J arrest the cell cycle of cultured vascular smooth muscle cells without suppression of c-myc expression. | 1992 | Exp. Cell Res. | pmid:1572402 |
Burgess HA et al. | PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15734787 |
Inoue K et al. | Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743408 |
Usui S et al. | Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15745794 |
Storer PD et al. | Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. | 2005 | J. Neuroimmunol. | pmid:15748950 |
Spik I et al. | Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. | 2005 | J. Immunol. | pmid:15749909 |
Mochizuki M et al. | Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15750045 |
Moulin D et al. | Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. | 2005 | Arthritis Rheum. | pmid:15751073 |
Lindström TM and Bennett PR | 15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15755849 |
Takashima T et al. | Relationship between peroxisome proliferator-activated receptor-gamma expression and differentiation of human esophageal squamous cell carcinoma. | 2005 | Oncol. Rep. | pmid:15756430 |
Pataki I et al. | In vivo effects of isatin on rat platelet eicosanoids. | 2005 | Platelets | pmid:15763895 |
Gallant MA et al. | Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. | 2005 | J. Bone Miner. Res. | pmid:15765187 |
Viñals M et al. | Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages. | 2005 | Cardiovasc. Res. | pmid:15769457 |
Yuan Z et al. | Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. | 2005 | Heart | pmid:15774612 |
Yuan J et al. | Ligands for peroxisome proliferator-activated receptor gamma have potent antitumor effect against human renal cell carcinoma. | 2005 | Urology | pmid:15780399 |
Kim S et al. | Synthesis of 15R-PGD2: a potential DP2 receptor agonist. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15780624 |
Marshall JC | Modeling MODS: what can be learned from animal models of the multiple-organ dysfunction syndrome? | 2005 | Intensive Care Med | pmid:15782317 |
Gazi L et al. | Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789622 |
Fowler CJ and Tiger G | Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. | 2005 | Biochem. Pharmacol. | pmid:15794945 |
Dore-Duffy P et al. | The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series. | 2005 | Microvasc. Res. | pmid:15797264 |
Masuko-Hongo K | [Role of prostaglandins in rheumatoid arthritis]. | 2005 | Nippon Rinsho | pmid:15799333 |
PPAR activators and gastroenterology. | 2004 | Drug News Perspect. | pmid:15801147 | |
Inoue K et al. | Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide. | 2005 | Arzneimittelforschung | pmid:15819389 |
Sanchez-Rodriguez J et al. | The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. | 2005 | Biochem. J. | pmid:15819613 |
Berry EB et al. | Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. | 2005 | Mol. Pharmacol. | pmid:15821150 |
Liu J et al. | Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15838654 |
Ji JD et al. | Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. | 2005 | Rheumatology (Oxford) | pmid:15840591 |
Mitchell MD et al. | Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues. | 2005 | J. Clin. Endocrinol. Metab. | pmid:15840748 |
Chen YC et al. | Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species. | 2005 | Biochim. Biophys. Acta | pmid:15843042 |
Ackerman WE et al. | Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. | 2005 | Biol. Reprod. | pmid:15843495 |
Ninomiya H et al. | Endothelin-1 induces stimulation of prostaglandin synthesis in cells obtained from canine airways by bronchoalveolar lavage. | 1992 | Prostaglandins | pmid:1584994 |
Drew PD et al. | Hormone regulation of microglial cell activation: relevance to multiple sclerosis. | 2005 | Brain Res. Brain Res. Rev. | pmid:15850670 |
Kämpfer H et al. | Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. | 2005 | Diabetes | pmid:15855344 |
Saito H | [Mast cells]. | 2005 | Nippon Rinsho | pmid:15861652 |
Andrews WJ et al. | Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862961 |
Allred CD and Kilgore MW | Selective activation of PPARgamma in breast, colon, and lung cancer cell lines. | 2005 | Mol. Cell. Endocrinol. | pmid:15866424 |
Marzocco S et al. | The cyclopentenone prostaglandin 15-deoxydelta(12,14)-prostaglandin J2 attenuates the development of zymosan-induced shock. | 2005 | Intensive Care Med | pmid:15868139 |