PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| el-Lati SG et al. | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | 1994 | J. Invest. Dermatol. | pmid:7513741 |
| Warren JB et al. | PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. | 1994 | Am. J. Physiol. | pmid:7515584 |
| D'Onofrio C et al. | Antiproliferative activity of cyclopentenone prostaglandins in early HTLV-1 infection is independent of IL-2 and is associated with HSP70 induction. | 1994 | Leukemia | pmid:7516027 |
| Okayama Y et al. | In vitro effects of H1-antihistamines on histamine and PGD2 release from mast cells of human lung, tonsil, and skin. | 1994 | Allergy | pmid:7518654 |
| Darius H et al. | Inhibition of human platelets and polymorphonuclear neutrophils by the potent and metabolically stable prostaglandin D2 analog ZK 118.182. | 1994 | Eur. J. Pharmacol. | pmid:7522176 |
| Polosa R et al. | [Mast cell mediator release after endobronchial challenge with adenosine 5'-monophosphate in asthmatic subjects]. | 1994 Apr-Jun | Ann. Ital. Med. Int. | pmid:7522500 |
| Takei M and Endo K | Histamine release and calcium concentrations in rat mast cells are dependent on intracellular ATP: effects of prostaglandin D2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7524104 |
| Ko FN et al. | YC-1, a novel activator of platelet guanylate cyclase. | 1994 | Blood | pmid:7527671 |
| Kaye AD et al. | Analysis of thromboxane receptor-mediated responses in the feline pulmonary vascular bed. | 1995 | Crit. Care Med. | pmid:7528116 |
| Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
| Crankshaw DJ and Gaspar V | Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. | 1995 | J. Reprod. Fertil. | pmid:7535849 |
| Leal-Berumen I et al. | Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells. | 1995 | J. Immunol. | pmid:7536779 |
| Parker J et al. | Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication. | 1995 | Antiviral Res. | pmid:7537950 |
| Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
| Murakami M et al. | Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7541141 |
| Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
| Horn EH et al. | Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia. | 1995 | Clin. Sci. | pmid:7545563 |
| Charlesworth EN | Role of basophils and mast cells in acute and late reactions in the skin. | 1995 | Chem. Immunol. | pmid:7546286 |
| Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
| Reanmongkol W et al. | Inhibitory effect of alkaloids extracted from the stem bark of Hunteria zeylanica on 5-lipoxygenase activity in vitro. | 1995 | Biol. Pharm. Bull. | pmid:7550132 |
| Negishi M et al. | Involvement of protein kinase in delta 12-prostaglandin J2-induced expression of rat heme oxygenase-1 gene. | 1995 | FEBS Lett. | pmid:7556684 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Rabe KF et al. | Hydrogen peroxide contracts human airways in vitro: role of epithelium. | 1995 | Am. J. Physiol. | pmid:7573466 |
| Hartmann K et al. | Effect of CC chemokines on mediator release from human skin mast cells and basophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7580286 |
| De Vries GW et al. | An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. | 1995 | Br. J. Pharmacol. | pmid:7582550 |
| Hespeling U et al. | Feedback-inhibition of glucagon-stimulated glycogenolysis in hepatocyte/Kupffer cell cocultures by glucagon-elicited prostaglandin production in Kupffer cells. | 1995 | Hepatology | pmid:7590678 |
| Murakami M et al. | IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. | 1995 | J. Immunol. | pmid:7594606 |
| Terao A et al. | Roles of prostaglandins D2 and E2 in interleukin-1-induced activation of norepinephrine turnover in the brain and peripheral organs of rats. | 1995 | J. Neurochem. | pmid:7595573 |
| Matsumoto K et al. | Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration. | 1995 | J. Biochem. | pmid:7608139 |
| Kawata R et al. | Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. | 1995 | J. Immunol. | pmid:7608559 |
| Peden DB and Dailey L | Modulation of mast cell functions by in vitro ozone exposure. | 1995 | Am. J. Physiol. | pmid:7611432 |
| Serrero G and Lepak NM | Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626101 |
| Lee JH et al. | Induction of p53 and apoptosis by delta 12-PGJ2 in human hepatocarcinoma SK-HEP-1 cells. | 1995 | FEBS Lett. | pmid:7628635 |
| Ikai K et al. | Effect of cytotoxic prostaglandin, delta 12-prostaglandin J2 on E-cadherin expression in transformed epidermal cells in culture. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630918 |
| Hu ZQ et al. | An essential role of prostaglandin E on mouse mast cell induction. | 1995 | J. Immunol. | pmid:7636261 |
| Araki M et al. | Isoflurane modulates phorbol myristate acetate-, prostaglandin D2-, and prostaglandin E2-induced alterations in hepatic flow and metabolism in the perfused liver in fasted rats. | 1994 | Anesth. Analg. | pmid:7639362 |
| Boie Y et al. | Molecular cloning and characterization of the human prostanoid DP receptor. | 1995 | J. Biol. Chem. | pmid:7642548 |
| Pandey HP et al. | Circadian variations of prostaglandins D2, E2, and F2 alpha in the cerebrospinal fluid of anesthetized rats. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7646520 |
| Refsnes M et al. | On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: the relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C. | 1995 | J. Cell. Physiol. | pmid:7650056 |
| Koizumi T et al. | Identification of a cis-regulatory element for delta 12-prostaglandin J2-induced expression of the rat heme oxygenase gene. | 1995 | J. Biol. Chem. | pmid:7665598 |
| Bull HA et al. | Basophil mediator release in atopic dermatitis. | 1993 | J. Invest. Dermatol. | pmid:7680056 |
| Campbell AM et al. | Modulation of eicosanoid and histamine release from human dispersed lung cells by terfenadine. | 1993 | Allergy | pmid:7681268 |
| Campbell AM et al. | Conjunctival provocation tests with codeine phosphate. Effect of disodium cromoglycate. | 1993 | Ann Allergy | pmid:7687104 |
| Charlesworth EN et al. | Cutaneous late-phase response in food-allergic children and adolescents with atopic dermatitis. | 1993 | Clin. Exp. Allergy | pmid:7687509 |
| al-Laith M and Pearce FL | On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells. | 1993 | Int. Arch. Allergy Immunol. | pmid:7689004 |
| Marone G et al. | Mechanisms of activation of human mast cells and basophils by general anesthetic drugs. | 1993 | Ann Fr Anesth Reanim | pmid:7690200 |
| Naclerio RM | Effects of antihistamines on inflammatory mediators. | 1993 | Ann Allergy | pmid:7690526 |
| Maxwell DL et al. | Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. | 1993 | Eur. Respir. J. | pmid:7693506 |
| Satoh S et al. | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. | 1994 | Neurosci. Res. | pmid:7708292 |
| Leifke E et al. | In vivo comparative study of the seizure- and ischemia-induced synthesis of eicosanoids in the brain of gerbils. | 1994 Sep-Oct | Arch Int Pharmacodyn Ther | pmid:7710301 |