PGD2
Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of PGD2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PGD2?
PGD2 is suspected in Asthma, Dehydration, Allergic rhinitis NOS, Rhinitis, Infertility, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PGD2
PubChem Associated disorders and diseases
What pathways are associated with PGD2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PGD2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with PGD2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PGD2?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PGD2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with PGD2?
Knock-out
Knock-out are used in the study 'Multiple roles of the prostaglandin D2 signaling pathway in reproduction.' (Rossitto M et al., 2015).
Rodent Model
Rodent Model are used in the study 'PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.' (Kong D et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with PGD2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tsuri T et al. | Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists. | 1997 | J. Med. Chem. | pmid:9357516 |
| Liakos P et al. | ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells. | 1997 | Am. J. Physiol. | pmid:9357777 |
| Minami T et al. | Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2. | 1997 | Br. J. Pharmacol. | pmid:9375954 |
| Li Y et al. | Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. | 1997 | Prostaglandins | pmid:9380795 |
| Fournier T et al. | Tumor necrosis factor-alpha inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. Synergistic action of cyclic AMP on cyclooxygenase-2 expression and prostaglandin E2 synthesis. | 1997 | J. Biol. Chem. | pmid:9388257 |
| Wettstein M and Häussinger D | Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. | 1997 | Hepatology | pmid:9397998 |
| Adams M et al. | Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. | 1997 | J. Clin. Invest. | pmid:9399962 |
| Ricote M et al. | The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. | 1998 | Nature | pmid:9422508 |
| Jiang C et al. | PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. | 1998 | Nature | pmid:9422509 |
| McGowan SE et al. | Peroxisome proliferators alter lipid acquisition and elastin gene expression in neonatal rat lung fibroblasts. | 1997 | Am. J. Physiol. | pmid:9435581 |
| Reginato MJ et al. | Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. | 1998 | J. Biol. Chem. | pmid:9442016 |
| Tan W et al. | Modulation of nicotinic AChR channels by prostaglandin E2 in chick sympathetic ganglion neurons. | 1998 | J. Neurophysiol. | pmid:9463448 |
| Nagoshi H et al. | Prostaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells. | 1998 | Circ. Res. | pmid:9468191 |
| Horak F et al. | Effect of continuous allergen challenge on clinical symptoms and mediator release in dust-mite-allergic patients. | 1998 | Allergy | pmid:9491231 |
| el Attar TM and Virji AS | Effects of indomethacin, cisplatin and delta 12-prostaglandin J2 on growth of oral squamous carcinoma cells. | 1997 Nov-Dec | Anticancer Res. | pmid:9494540 |
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| Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
| Giardiello FM et al. | Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. | 1998 | Dig. Dis. Sci. | pmid:9512123 |
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| Liao CH et al. | Effect of PP1D-1, a synthetic antiplatelet compound, on rabbit platelets. | 1998 | Jpn. J. Pharmacol. | pmid:9541276 |
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| Akarsu ES et al. | Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2. | 1998 | Epilepsy Res. | pmid:9551845 |
| Daculsi R et al. | Effect of PGE2 on the cell surface molecule expression in PMA treated thymocytes. | 1998 | Immunol. Lett. | pmid:9557948 |
| Chan CL and Lau HY | Effects of prostanoid receptor agonists on immunologically-activated rat peritoneal mast cells. | 1998 | Inflamm. Res. | pmid:9561397 |
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| Mooney JJ et al. | Signal transduction by platelet adenylate cyclase: alterations in depressed patients may reflect impairment in the coordinated integration of cellular signals (coincidence detection). | 1998 | Biol. Psychiatry | pmid:9564442 |
| Souza SC et al. | BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones. | 1998 | Diabetes | pmid:9568706 |
| Nagy L et al. | Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. | 1998 | Cell | pmid:9568715 |
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| Morrow JD et al. | Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. | 1998 | Arch. Biochem. Biophys. | pmid:9578611 |
| Wright DH et al. | Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. | 1998 | Br. J. Pharmacol. | pmid:9579725 |
| Dorta-Contreras AJ et al. | [Beta trace protein in the cerebrospinal fluid and serum in meningoencephalitis]. | 1998 | Rev Neurol | pmid:9585948 |
| Kalgutkar AS et al. | Aspirin-like molecules that covalently inactivate cyclooxygenase-2. | 1998 | Science | pmid:9596581 |
| Tsai WJ et al. | Characterization of the antiplatelet effects of (2S)-5-methoxy-6-methylflavan-7-ol from Draconis Resina. | 1998 | Eur. J. Pharmacol. | pmid:9617759 |
| Demoly P et al. | [Nose and sinus: anatomo-pathologic relations]. | 1998 | Allerg Immunol (Paris) | pmid:9631692 |
| Scammell T et al. | Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9636223 |
| Moon TC et al. | Regulation of cyclooxygenase-2 and endogenous cytokine expression by bacterial lipopolysaccharide that acts in synergy with c-kit ligand and Fc epsilon receptor I crosslinking in cultured mast cells. | 1998 | Cell. Immunol. | pmid:9636692 |
| Iijima K et al. | Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642130 |
| Ikai K et al. | Induction of apoptosis, p53 and heme oxygenase-1 by cytotoxic prostaglandin delta12-PGJ2 in transformed endothelial cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654403 |
| Nishino S et al. | Cerebrospinal fluid prostaglandins and corticotropin releasing factor in schizophrenics and controls: relationship to sleep architecture. | 1998 | Psychiatry Res | pmid:9657418 |
| Thomson AM et al. | Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase. | 1998 | Biochem. J. | pmid:9657971 |
| Marx N et al. | Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. | 1998 | Am. J. Pathol. | pmid:9665460 |
| Seckl J | Mechanisms of fetal origins of health problems in adults need to be investigated. | 1998 | BMJ | pmid:9665923 |